ID Q1INT3_KORVE Unreviewed; 725 AA.
AC Q1INT3;
DT 13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Glutamate carboxypeptidase II {ECO:0000313|EMBL:ABF41467.1};
DE EC=3.4.17.21 {ECO:0000313|EMBL:ABF41467.1};
GN OrderedLocusNames=Acid345_2466 {ECO:0000313|EMBL:ABF41467.1};
OS Koribacter versatilis (strain Ellin345).
OC Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC Koribacter.
OX NCBI_TaxID=204669 {ECO:0000313|EMBL:ABF41467.1, ECO:0000313|Proteomes:UP000002432};
RN [1] {ECO:0000313|EMBL:ABF41467.1, ECO:0000313|Proteomes:UP000002432}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ellin345 {ECO:0000313|EMBL:ABF41467.1,
RC ECO:0000313|Proteomes:UP000002432};
RX PubMed=19201974; DOI=10.1128/AEM.02294-08;
RA Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT "Three genomes from the phylum Acidobacteria provide insight into the
RT lifestyles of these microorganisms in soils.";
RL Appl. Environ. Microbiol. 75:2046-2056(2009).
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; CP000360; ABF41467.1; -; Genomic_DNA.
DR RefSeq; WP_011523268.1; NC_008009.1.
DR AlphaFoldDB; Q1INT3; -.
DR STRING; 204669.Acid345_2466; -.
DR EnsemblBacteria; ABF41467; ABF41467; Acid345_2466.
DR KEGG; aba:Acid345_2466; -.
DR eggNOG; COG2234; Bacteria.
DR HOGENOM; CLU_005688_2_1_0; -.
DR OrthoDB; 233977at2; -.
DR Proteomes; UP000002432; Chromosome.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:UniProtKB-EC.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000313|EMBL:ABF41467.1};
KW Hydrolase {ECO:0000313|EMBL:ABF41467.1};
KW Protease {ECO:0000313|EMBL:ABF41467.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002432}.
FT DOMAIN 158..245
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 338..476
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 615..720
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
FT REGION 459..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 78690 MW; 1BDA7B8A9E143744 CRC64;
MRPLVSLIVF WTLLIAPFLG TELGDPTKSV FEPPNAIAGF EKPIAQLALE KKFLAVPDPK
HAEQDMRALT ATPHLATTPE DRKTADYVLQ KFKEAGLQAS IEEYKVYFGI PESVSIDIVA
PEGVVLHGPS PERVDGDDGS KDSRILPAFN GYTPSADVTA EVLYANYGRP EDFDTLAQAG
VDVKGKLVII RYGEIFRGVK VLQAQQRGAA GVILYSDPMD DGYFKGDVYP KGPYRPSSAV
QRGDVHFMFR YPGDPTTPGA PSSATAERTE AAQSASLPKI PVLPLSYADA SPILQHLAGP
ESPRSWQGAL PFTYHLGVGP VKVHLKIAVH YEYRTIWNVI GTVKGAEYPS DIVLSGNHRD
AWVFGAADPG SGTVAQLEAV RGIGQLLKAG WRPKRTIIFA SWDAEEQGMV GSTEWVEQHA
QELSGAVAYF NMDVAVTGPN FAAASVPSLK QFMRDVAKSV PSPQGGSVYD AWTERTSGKS
PQRNEVFPDV NGSARHSSAA PPHQDVAVGD LGSGSDYTPF LEHIGVASAD MGSHGPYGVY
HSAFDDYTWF TKFADPKFAY EQQMARLHGL QVLRMADADV LPFDYEDYGQ EIEAYIEYTK
QRAAESFPEG GPKFDELTKA SKRLQSAGSM LLGAVKAGRA ASPARINTAL RDAERAFLTN
GLPSRPWFRH AIYAPGESTG YEAIVLPGIT EAIEHHDQQA LVEQIQLTTA AINHASEILE
SAHSF
//
