ID Q1J4G4_STRPF Unreviewed; 643 AA.
AC Q1J4G4;
DT 13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Fibronectin-binding protein {ECO:0000313|EMBL:ABF38772.1};
GN OrderedLocusNames=MGAS10750_Spy1822 {ECO:0000313|EMBL:ABF38772.1};
OS Streptococcus pyogenes serotype M4 (strain MGAS10750).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=370554 {ECO:0000313|EMBL:ABF38772.1, ECO:0000313|Proteomes:UP000002434};
RN [1] {ECO:0000313|EMBL:ABF38772.1, ECO:0000313|Proteomes:UP000002434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGAS10750 {ECO:0000313|EMBL:ABF38772.1,
RC ECO:0000313|Proteomes:UP000002434};
RX PubMed=16636287; DOI=10.1073/pnas.0510279103;
RA Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R.,
RA Musser J.M.;
RT "Molecular genetic anatomy of inter- and intraserotype variation in the
RT human bacterial pathogen group A Streptococcus.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000262; ABF38772.1; -; Genomic_DNA.
DR RefSeq; WP_011529065.1; NC_008024.1.
DR AlphaFoldDB; Q1J4G4; -.
DR KEGG; spi:MGAS10750_Spy1822; -.
DR HOGENOM; CLU_418507_0_0_9; -.
DR Proteomes; UP000002434; Chromosome.
DR InterPro; IPR004237; Fibron_repeat-bd.
DR InterPro; IPR019931; LPXTG_anchor.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR Pfam; PF02986; Fn_bind; 2.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR SUPFAM; SSF101094; Staphylocoagulase; 1.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE 4: Predicted;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Secreted {ECO:0000256|ARBA:ARBA00022512}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..643
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039571415"
FT DOMAIN 608..643
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|PROSITE:PS50847"
FT REGION 329..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..357
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 643 AA; 70723 MW; 2BB9E34E18B81CC2 CRC64;
MTKKFIKSAV ILGLASITIS MTQPVEAIAN RLEYQEQYER VKKELDALKE KGPKLGERSL
YFRVVNKFLS WFGQVWDPLA IEETDHLLDL IGQVNYLVSN TEFQAPEYQE AKNKLDLAVA
GYDLYLSREK GRGDAPDYQV TQLTLEQIAT IKTKIQEALK TFAQEVKTIQ QTHPDLFPHA
YVLNAKTSAI DGKAQPFLVN GYYDVFYKQF LFTNTKDGYN YNKEADNLTS YQNLIKELLE
LKTKIDQLTT DKPKNDLLET LMWQSKFTLS DFRRTSRLSA YYTQEDYVKK VVLSEEAPNL
RTAKEKVKTL KGILHDYYVE TNDLEKAKEY HVEDETSPSQ PEAPAKPEAP SPSPAPGQKP
AEDERSSQAT EPANPSKEDS STDASQGSHD SENPATDSPS QPQAPDQGNH QSQVPNDKPQ
TDKTDTPNVP APPQDTPKVP EAGGQSGPAG NAEEKAPDSG PKESDQSSSK ESPSVGEDTT
PNQPDVLVGG QSEPIDITED TITDAPPTVS GHNASTQPQS VVEDTAPQRP DVLVGGQSEP
IDITQDTQPG MSGSNDATVI NEDTKPKRVF HFDNKESQAS EKAAEQKLAP HDSHTTPQAS
DDTAAPHLPA SGDKPEKVFA LAALTMVAAA GLLSKKRRNT DKN
//
