ID Q1J6D3_STRPF Unreviewed; 217 AA.
AC Q1J6D3;
DT 13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Phosphate-specific transport system accessory protein PhoU {ECO:0000256|PIRNR:PIRNR003107};
GN Name=phoU {ECO:0000313|EMBL:ABF38050.1};
GN OrderedLocusNames=MGAS10750_Spy1100 {ECO:0000313|EMBL:ABF38050.1};
OS Streptococcus pyogenes serotype M4 (strain MGAS10750).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=370554 {ECO:0000313|EMBL:ABF38050.1, ECO:0000313|Proteomes:UP000002434};
RN [1] {ECO:0000313|EMBL:ABF38050.1, ECO:0000313|Proteomes:UP000002434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGAS10750 {ECO:0000313|EMBL:ABF38050.1,
RC ECO:0000313|Proteomes:UP000002434};
RX PubMed=16636287; DOI=10.1073/pnas.0510279103;
RA Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R.,
RA Musser J.M.;
RT "Molecular genetic anatomy of inter- and intraserotype variation in the
RT human bacterial pathogen group A Streptococcus.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
CC -!- FUNCTION: Plays a role in the regulation of phosphate uptake.
CC {ECO:0000256|PIRNR:PIRNR003107}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR003107}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR003107}.
CC -!- SIMILARITY: Belongs to the PhoU family.
CC {ECO:0000256|PIRNR:PIRNR003107}.
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DR EMBL; CP000262; ABF38050.1; -; Genomic_DNA.
DR RefSeq; WP_002984514.1; NC_008024.1.
DR AlphaFoldDB; Q1J6D3; -.
DR GeneID; 69900795; -.
DR KEGG; spi:MGAS10750_Spy1100; -.
DR HOGENOM; CLU_078518_2_0_9; -.
DR Proteomes; UP000002434; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030643; P:intracellular phosphate ion homeostasis; IEA:InterPro.
DR GO; GO:0045936; P:negative regulation of phosphate metabolic process; IEA:InterPro.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR028366; P_transport_PhoU.
DR InterPro; IPR038078; PhoU-like_sf.
DR InterPro; IPR026022; PhoU_dom.
DR NCBIfam; TIGR02135; phoU_full; 1.
DR PANTHER; PTHR42930; PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU; 1.
DR PANTHER; PTHR42930:SF3; PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU; 1.
DR Pfam; PF01895; PhoU; 2.
DR PIRSF; PIRSF003107; PhoU; 1.
DR SUPFAM; SSF109755; PhoU-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR003107};
KW Phosphate transport {ECO:0000256|PIRNR:PIRNR003107};
KW Transport {ECO:0000256|PIRNR:PIRNR003107}.
FT DOMAIN 19..104
FT /note="PhoU"
FT /evidence="ECO:0000259|Pfam:PF01895"
FT DOMAIN 121..206
FT /note="PhoU"
FT /evidence="ECO:0000259|Pfam:PF01895"
SQ SEQUENCE 217 AA; 24956 MW; 8732D9E98925A4F5 CRC64;
MLRTKFEEEL DKLHNQFYSM GTEVLAQINK TVRAFVSHDR ELAKEVIEED DTINNFETKL
EKKSLEIIAL QQPVSNDLRM VITVLKASSD IERMGDHAAS IAKATIRMKG EERIPVVEEQ
INLMGKAVKQ MVEEALNAYI NADDTKAYEI AASDEIIDQY FRNIQTLAVE EIRKSPDAVF
AGKEYFQVLM YLERIGDYAR NICEWIVYLK TGKIIEL
//
