ID Q1JG45_STRPD Unreviewed; 173 AA.
AC Q1JG45;
DT 13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Transcriptional regulator, biotin repressor family {ECO:0000313|EMBL:ABF34299.1};
GN OrderedLocusNames=MGAS10270_Spy1234 {ECO:0000313|EMBL:ABF34299.1};
OS Streptococcus pyogenes serotype M2 (strain MGAS10270).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=370552 {ECO:0000313|EMBL:ABF34299.1, ECO:0000313|Proteomes:UP000002436};
RN [1] {ECO:0000313|EMBL:ABF34299.1, ECO:0000313|Proteomes:UP000002436}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGAS10270 {ECO:0000313|EMBL:ABF34299.1,
RC ECO:0000313|Proteomes:UP000002436};
RX PubMed=16636287; DOI=10.1073/pnas.0510279103;
RA Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R.,
RA Musser J.M.;
RT "Molecular genetic anatomy of inter- and intraserotype variation in the
RT human bacterial pathogen group A Streptococcus.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
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DR EMBL; CP000260; ABF34299.1; -; Genomic_DNA.
DR RefSeq; WP_002983930.1; NZ_CVUH01000008.1.
DR AlphaFoldDB; Q1JG45; -.
DR GeneID; 69900621; -.
DR KEGG; sph:MGAS10270_Spy1234; -.
DR HOGENOM; CLU_108798_0_0_9; -.
DR Proteomes; UP000002436; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR Gene3D; 3.30.1340.20; 3H domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR035922; 3H_dom_sf.
DR InterPro; IPR004173; 3H_domain.
DR InterPro; IPR013196; HTH_11.
DR InterPro; IPR026043; NadR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR40068; TRANSCRIPTION REPRESSOR NIAR-RELATED; 1.
DR PANTHER; PTHR40068:SF1; TRANSCRIPTION REPRESSOR NIAR-RELATED; 1.
DR Pfam; PF02829; 3H; 1.
DR Pfam; PF08279; HTH_11; 1.
DR PIRSF; PIRSF037847; NiaR; 1.
DR SUPFAM; SSF75500; Putative transcriptional regulator TM1602, C-terminal domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PIRSR:PIRSR037847-1};
KW Nickel {ECO:0000256|PIRSR:PIRSR037847-1}.
FT DOMAIN 6..59
FT /note="Helix-turn-helix type 11"
FT /evidence="ECO:0000259|Pfam:PF08279"
FT DOMAIN 73..169
FT /note="3H"
FT /evidence="ECO:0000259|Pfam:PF02829"
FT BINDING 77
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
FT BINDING 85
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
FT BINDING 144
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
FT BINDING 146
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
SQ SEQUENCE 173 AA; 19175 MW; 28E73CC3BB758C1F CRC64;
MKAEDRRQKI IECLNSEQKA VSATRLGKLL GVSRQVIVGD IALLRAQQID IISTPKGYIM
STALYSHQFC ARIVCQHNVE ETKKELEIIL AHQGIITTVE VEHPIYGMIT APLNIKTHSD
VTNFMSKLSQ SKAELLSSLT EGLHSHLISC PSQEAFLAIK HDLELAGILY KGI
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