ID Q1JMC4_STRPC Unreviewed; 423 AA.
AC Q1JMC4;
DT 13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=HlyD family secretion protein {ECO:0000313|EMBL:ABF31888.1};
GN OrderedLocusNames=MGAS9429_Spy0700 {ECO:0000313|EMBL:ABF31888.1};
OS Streptococcus pyogenes serotype M12 (strain MGAS9429).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=370551 {ECO:0000313|EMBL:ABF31888.1, ECO:0000313|Proteomes:UP000002433};
RN [1] {ECO:0000313|EMBL:ABF31888.1, ECO:0000313|Proteomes:UP000002433}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGAS9429 {ECO:0000313|EMBL:ABF31888.1,
RC ECO:0000313|Proteomes:UP000002433};
RX PubMed=16636287; DOI=10.1073/pnas.0510279103;
RA Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R.,
RA Musser J.M.;
RT "Molecular genetic anatomy of inter- and intraserotype variation in the
RT human bacterial pathogen group A Streptococcus.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP000259; ABF31888.1; -; Genomic_DNA.
DR RefSeq; WP_002990240.1; NC_008021.1.
DR AlphaFoldDB; Q1JMC4; -.
DR KEGG; spk:MGAS9429_Spy0700; -.
DR HOGENOM; CLU_018816_14_5_9; -.
DR Proteomes; UP000002433; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR32347; EFFLUX SYSTEM COMPONENT YKNX-RELATED; 1.
DR PANTHER; PTHR32347:SF14; EFFLUX SYSTEM COMPONENT YKNX-RELATED; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..273
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 401..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 165..192
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 423 AA; 45339 MW; 31B45F08DA5B366E CRC64;
MSKRGKIKIT TKTKLITASV ITLVLIITGV VLWKQQQNTL TADIAKEPYS TVSVTEGSIA
SSTLLSGTVK ALSEEYIYFD ANKGNDATVT VKVGDQVTQG QQLVQYNTTT AQSAYDTAVR
SLNKIGRQIN HLKTYGVPAV STETNKDEAT GEETTTTVQP SAQQNANYKQ QLQDLNDAYA
DAQAEVNKAQ IALNDTVVIS SVSGTVVEVN NDIDPSSKNS QTLVHVATEG QLQVKGTLTE
YDLANVKVGQ SVKIKSKVYS NQEWTGKISY VSNYPTESNA GSTTPAGSTG AGSSTGAAYD
YKIDIISPLN QLKQGFTVSV EVVNEAKQAL VPLTAVIKKD KKHYVWTYDD ATGKAKKVEV
TLGNADAQQQ EIHKGVAVGD IVIANPDKNI KPDKKLEGVI SIGTNTKPEK DSQSKNKKSG
VDK
//