ID Q1JPC5_BOVIN Unreviewed; 311 AA.
AC Q1JPC5;
DT 13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 135.
DE SubName: Full=CD86 antigen {ECO:0000313|EMBL:ABF57384.1};
DE SubName: Full=CD86 molecule {ECO:0000313|Ensembl:ENSBTAP00000032224.2};
GN Name=CD86 {ECO:0000313|EMBL:ABF57384.1,
GN ECO:0000313|Ensembl:ENSBTAP00000032224.2,
GN ECO:0000313|VGNC:VGNC:27051};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:ABF57384.1};
RN [1] {ECO:0000313|EMBL:ABF57384.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:ABF57384.1};
RX PubMed=11282978; DOI=10.1101/gr.170101;
RA Smith T.P., Grosse W.M., Freking B.A., Roberts A.J., Stone R.T., Casas E.,
RA Wray J.E., White J., Cho J., Fahrenkrug S.C., Bennett G.L., Heaton M.P.,
RA Laegreid W.W., Rohrer G.A., Chitko-McKown C.G., Pertea G., Holt I.,
RA Karamycheva S., Liang F., Quackenbush J., Keele J.W.;
RT "Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries
RT and construction of a gene index for cattle.";
RL Genome Res. 11:626-630(2001).
RN [2] {ECO:0000313|EMBL:ABF57384.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:ABF57384.1};
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [3] {ECO:0000313|EMBL:ABF57384.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:ABF57384.1};
RA Harhay G.P., Sonstegard T.S., Van Tassell C.P., Clawson M.L., Heaton M.P.,
RA Keele J.W., Snelling W.M., Weidmann R.T., Smith T.P.L.;
RT "Sequencing and analysis of Bos taurus full-length insert cDNA clones.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSBTAP00000032224.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000032224.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSBTAP00000032224.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000032224.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; BT025428; ABF57384.1; -; mRNA.
DR RefSeq; XP_005201444.1; XM_005201387.3.
DR PaxDb; 9913-ENSBTAP00000032224; -.
DR Ensembl; ENSBTAT00000032289.3; ENSBTAP00000032224.2; ENSBTAG00000013118.6.
DR GeneID; 414345; -.
DR CTD; 942; -.
DR VEuPathDB; HostDB:ENSBTAG00000013118; -.
DR VGNC; VGNC:27051; CD86.
DR eggNOG; ENOG502S1FF; Eukaryota.
DR GeneTree; ENSGT00940000161500; -.
DR HOGENOM; CLU_071073_0_0_1; -.
DR OMA; LPCQFTN; -.
DR TreeFam; TF331083; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000013118; Expressed in monocyte and 101 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd16087; IgV_CD86; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR037677; CD86_IgV.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR25466; T-LYMPHOCYTE ACTIVATION ANTIGEN; 1.
DR PANTHER; PTHR25466:SF2; T-LYMPHOCYTE ACTIVATION ANTIGEN CD86; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..311
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014103925"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..134
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 281..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 311 AA; 35045 MW; 3FFD9EC071460DE5 CRC64;
MRFKCTMGLR NTLIVMALLL SVSTVPFSGA ASLKSHAFFN ETGELPCHFP NTQNLSLDEL
VIFWQDQNKL VLYELFKGQE KPNNVNPKYI GRTSFDQDSW TLRLHNVQIK DTGSYQCFIH
HRRSQGLVSI HQMSSDLIVL ANFSQPEIRL IANQTEKSNI INLTCSSIQG YPEPQRMYVS
LNTTNSSSTY DAVMKKSQSN ITELYNVSIS VSFPIPPETN VTIFCALQLE PTKIILSQPY
NIDAKSPVPS PPVPDHILWI AALLVTVVVS GMVFLTLKKR KKKQPGPSNE CEIIKVEEKE
SEQTAKRTPR T
//
