ID HXB6B_TAKRU Reviewed; 233 AA.
AC Q1KKX1;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 24-JAN-2024, entry version 82.
DE RecName: Full=Homeobox protein Hox-B6b;
GN Name=hoxb6b;
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT regulatory elements within and outside Hox gene clusters.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; DQ481666; ABF22423.1; -; Genomic_DNA.
DR RefSeq; XP_003961127.1; XM_003961078.2.
DR AlphaFoldDB; Q1KKX1; -.
DR SMR; Q1KKX1; -.
DR STRING; 31033.ENSTRUP00000030235; -.
DR Ensembl; ENSTRUT00000030352.3; ENSTRUP00000030235.2; ENSTRUG00000011945.3.
DR GeneID; 101079641; -.
DR KEGG; tru:101079641; -.
DR CTD; 58053; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000165065; -.
DR InParanoid; Q1KKX1; -.
DR OMA; DSDRSCA; -.
DR OrthoDB; 728401at2759; -.
DR Proteomes; UP000005226; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR PANTHER; PTHR45659:SF14; HOMEOBOX PROTEIN HOX-A6; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..233
FT /note="Homeobox protein Hox-B6b"
FT /id="PRO_0000265982"
FT DNA_BIND 155..214
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 213..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 136..141
FT /note="Antp-type hexapeptide"
SQ SEQUENCE 233 AA; 26629 MW; 75414859B5B95018 CRC64;
MSSYFVNSTF PVSLPGGQDS LLGQIPLYSS GYTDPLRHYS NAATYGAANM QEKVYPASYY
QQTGAAAIYG RAGGGAPCEY NPVGTFYKET EGSCAFSSRD DQPLFVTQEH QQRKVECPEQ
SVSMGSSIDD KSSTLIYPWM QRMNACSAGP FGNSGRRGRQ TYTRYQTLEL EKEFHFNRYL
TRRRRIEISH ALCLTERQIK IWFQNRRMKW KKENKLLNPS KTPEEEEEAE KKS
//
