ID Q1L615_ENTCL Unreviewed; 263 AA.
AC Q1L615;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN Name=aadA2 {ECO:0000313|EMBL:AAY85125.1};
GN Synonyms=aadA {ECO:0000313|EMBL:RAZ63548.1};
GN ORFNames=DM877_26745 {ECO:0000313|EMBL:RXW26006.1}, DP202_20225
GN {ECO:0000313|EMBL:RAZ63548.1};
OS Enterobacter cloacae.
OG Plasmid pQC {ECO:0000313|EMBL:AAY85125.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX NCBI_TaxID=550 {ECO:0000313|EMBL:AAY85125.1};
RN [1] {ECO:0000313|EMBL:AAY85125.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pQC {ECO:0000313|EMBL:AAY85125.1};
RX PubMed=16704842;
RA Paauw A., Fluit A.C., Verhoef J., Leverstein-van Hall M.A.;
RT "Enterobacter cloacae outbreak and emergence of quinolone resistance gene
RT in Dutch hospital.";
RL Emerg. Infect. Dis. 12:807-812(2006).
RN [2] {ECO:0000313|EMBL:ADU16115.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E79 {ECO:0000313|EMBL:ADU16115.1};
RA Santos C., Lima C., Mendo S.;
RT "New class 1 integron described in an Enterobacter cloacae strain in
RT Portugal.";
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ADX06988.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YMC01/10/R768 {ECO:0000313|EMBL:ADX06988.1};
RA Yong D., Han S.H., Kim Y.A., Choi J.Y., Yum J.H., Lee K., Kim J.M.,
RA Chong Y.;
RT "Genetic regions surrounding qnrA in Korean Enterobacter cloacae strain
RT isolated in 2001.";
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AEC47419.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NF08-5296 {ECO:0000313|EMBL:AEC47419.1};
RA Wu K., Wang F., Sun J., Rui Y.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:RAZ63548.1, ECO:0000313|Proteomes:UP000251576}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=99B3 {ECO:0000313|EMBL:RAZ63548.1,
RC ECO:0000313|Proteomes:UP000251576};
RA Jousset A.B., Oueslati S., Bernabeu S., Takissian J., Creton E., Vogel A.,
RA Cotellon G., Bonnin R.A., Dortet L., Naas T.;
RT "ACT-28, a chromosomally-encoded AmpC with carbapenemase activity from
RT Enterobacter kobei.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:RXW26006.1, ECO:0000313|Proteomes:UP000290875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GEO_4_Eff_A {ECO:0000313|EMBL:RXW26006.1,
RC ECO:0000313|Proteomes:UP000290875};
RA Mathys D.A., Mollenkopf D.F., Feicht S.M., Adams R.J., Albers A.L.,
RA Grooters S.V., Stuever D.M., Daniels J.B., Wittum T.E.;
RT "Carbapenemase-producing Enterobacteriaceae present in wastewater treatment
RT plant effluent and nearby surface waters in the US.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672,
CC ECO:0000256|PIRNR:PIRNR000819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070,
CC ECO:0000256|PIRNR:PIRNR000819};
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DR EMBL; DQ019420; AAY85125.1; -; Genomic_DNA.
DR EMBL; HM998987; ADU16115.1; -; Genomic_DNA.
DR EMBL; HQ184955; ADX06988.1; -; Genomic_DNA.
DR EMBL; HQ880259; AEC47419.1; -; Genomic_DNA.
DR EMBL; QMDH01000048; RAZ63548.1; -; Genomic_DNA.
DR EMBL; QJSL01000065; RXW26006.1; -; Genomic_DNA.
DR PATRIC; fig|550.267.peg.4990; -.
DR Proteomes; UP000251576; Unassembled WGS sequence.
DR Proteomes; UP000290875; Unassembled WGS sequence.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|PIRNR:PIRNR000819};
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW ECO:0000313|EMBL:ADX06988.1}; Plasmid {ECO:0000313|EMBL:AAY85125.1};
KW Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:AAY85125.1}.
FT DOMAIN 28..97
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 153..254
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 263 AA; 29549 MW; D7FB27184F7D6B26 CRC64;
MRVAVTIEIS NQLSEVLSVI ERHLESTLLA VHLYGSAVDG GLKPYSDIDL LVTVAVKLDE
TTRRALLNDL MEASAFPGES ETLRAIEVTL VVHDDIIPWR YPAKRELQFG EWQRNDILAG
IFEPAMIDID LAILLTKARE HSVALVGPAA EEFFDPVPEQ DLFEALRETL KLWNSQPDWA
GDERNVVLTL SRIWYSAITG KIAPKDVAAD WAIKRLPAQY QPVLLEAKQA YLGQKEDHLA
SRADHLEEFI RFVKGEIIKS VGK
//