ID Q1LEP9_CUPMC Unreviewed; 520 AA.
AC Q1LEP9;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Protein CyaE {ECO:0000256|PIRNR:PIRNR001892};
GN OrderedLocusNames=Rmet_4512 {ECO:0000313|EMBL:ABF11377.1};
OS Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS CH34) (Ralstonia metallidurans).
OG Plasmid megaplasmid CH34 {ECO:0000313|Proteomes:UP000002429}.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=266264 {ECO:0000313|EMBL:ABF11377.1, ECO:0000313|Proteomes:UP000002429};
RN [1] {ECO:0000313|Proteomes:UP000002429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34
RC {ECO:0000313|Proteomes:UP000002429};
RC PLASMID=Plasmid megaplasmid CH34 {ECO:0000313|Proteomes:UP000002429};
RX PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT master survivalist in harsh and anthropogenic environments.";
RL PLoS ONE 5:E10433-E10433(2010).
CC -!- FUNCTION: CyaE is necessary for transport of calmodulin-sensitive
CC adenylate cyclase-hemolysin (cyclolysin).
CC {ECO:0000256|PIRNR:PIRNR001892}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|PIRNR:PIRNR001892}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR001892}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613, ECO:0000256|PIRNR:PIRNR001892}.
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DR EMBL; CP000353; ABF11377.1; -; Genomic_DNA.
DR RefSeq; WP_011518970.1; NC_007974.2.
DR AlphaFoldDB; Q1LEP9; -.
DR KEGG; rme:Rmet_4512; -.
DR eggNOG; COG1538; Bacteria.
DR HOGENOM; CLU_012817_10_2_4; -.
DR Proteomes; UP000002429; Plasmid megaplasmid CH34.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR028351; CyaE.
DR InterPro; IPR003423; OMP_efflux.
DR PANTHER; PTHR30026:SF20; OUTER MEMBRANE EFFLUX PROTEIN-RELATED; 1.
DR PANTHER; PTHR30026; OUTER MEMBRANE PROTEIN TOLC; 1.
DR Pfam; PF02321; OEP; 2.
DR PIRSF; PIRSF001892; CyaE; 1.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|PIRNR:PIRNR001892};
KW Cytolysis {ECO:0000256|PIRNR:PIRNR001892};
KW Hemolysis {ECO:0000256|PIRNR:PIRNR001892};
KW Membrane {ECO:0000256|PIRNR:PIRNR001892};
KW Plasmid {ECO:0000313|EMBL:ABF11377.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002429};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|PIRNR:PIRNR001892}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..520
FT /note="Protein CyaE"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004193430"
FT REGION 29..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 53533 MW; 43DF1AB0E52F216C CRC64;
MPRTGLPIFP LMLLGASLAG CATASLDLAP EQPDRPWQPT TTASGELVPG KPSATANTGK
PADYRLPANS ALASITPPAA LDPAYPYTLP ELIDMAESAN PITRVAWNDA RNAALAAGIA
KSSYLPQISA SALGGYQNGH GSVSGALGSV GTNSSGHGGV GVLSLQWLLF DFGERAGIVE
AAEQTSLAAN IAFTAAHQRI IHDVSVAFYR YQAARTRAGT VQQAMENADA VLAAAKSRFQ
RGIGTVVEVA QATQNRAQTN LAMVQARGAE TDAYLALVTA IGISPLSKPR IAEMPVRPLS
PALHSSVEQI VESAIARRPD VLGAYAIERA SQAKVKAAEA EFLPKVFMSA FTSYASGGSS
ITAIPSVAQQ APTVNLNGYR YGASVFLGIT VPIYDGGLRS AVLTQARNDA DSASTKLTRA
KEESVRQVVV SQSALETSLA AYEAAKALAD AAQITYDAAF AAYRKGVGTV TDANLAQNQL
LLARNASADA YSGALSAAAA LALATGAVGA TPEPGGWAPR
//
