ID Q1LUE8_DANRE Unreviewed; 555 AA.
AC Q1LUE8; A0A8M1PDY9;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=Hyaluronan synthase 3 {ECO:0000313|Ensembl:ENSDARP00000074268, ECO:0000313|RefSeq:NP_775327.2};
DE EC=2.4.1.212 {ECO:0000313|RefSeq:NP_775327.2};
GN Name=has3 {ECO:0000313|Ensembl:ENSDARP00000074268,
GN ECO:0000313|RefSeq:NP_775327.2, ECO:0000313|ZFIN:ZDB-GENE-021118-1};
GN Synonyms=af190743gs2 {ECO:0000313|RefSeq:NP_775327.2}, dg42III
GN {ECO:0000313|RefSeq:NP_775327.2}, xx:af190743gs1
GN {ECO:0000313|RefSeq:NP_775327.2}, xx:af190743gs2
GN {ECO:0000313|RefSeq:NP_775327.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000074268};
RN [1] {ECO:0000313|RefSeq:NP_775327.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_775327.2};
RX PubMed=14729574; DOI=10.1242/dev.00954;
RA Bakkers J., Kramer C., Pothof J., Quaedvlieg N.E., Spaink H.P.,
RA Hammerschmidt M.;
RT "Has2 is required upstream of Rac1 to govern dorsal migration of lateral
RT cells during zebrafish gastrulation.";
RL Development 131:525-537(2004).
RN [2] {ECO:0000313|RefSeq:NP_775327.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_775327.2};
RX PubMed=24067352; DOI=10.1242/dev.098061;
RA Geng F.S., Abbas L., Baxendale S., Holdsworth C.J., Swanson A.G.,
RA Slanchev K., Hammerschmidt M., Topczewski J., Whitfield T.T.;
RT "Semicircular canal morphogenesis in the zebrafish inner ear requires the
RT function of gpr126 (lauscher), an adhesion class G protein-coupled receptor
RT gene.";
RL Development 140:4362-4374(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000074268, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000074268};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000074268}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000074268};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_775327.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_775327.2};
RX PubMed=26156497;
RA Missinato M.A., Tobita K., Romano N., Carroll J.A., Tsang M.;
RT "Extracellular component hyaluronic acid and its receptor Hmmr are required
RT for epicardial EMT during heart regeneration.";
RL Cardiovasc. Res. 107:487-498(2015).
RN [6] {ECO:0000313|RefSeq:NP_775327.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_775327.2};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [7] {ECO:0000313|RefSeq:NP_775327.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_775327.2};
RX PubMed=27434666;
RA Askary A., Smeeton J., Paul S., Schindler S., Braasch I., Ellis N.A.,
RA Postlethwait J., Miller C.T., Crump J.G.;
RT "Ancient origin of lubricated joints in bony vertebrates.";
RL Elife 5:e16415-e16415(2016).
RN [8] {ECO:0000313|RefSeq:NP_775327.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_775327.2};
RX PubMed=26828861;
RA Govindan J., Tun K.M., Iovine M.K.;
RT "Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between
RT the Hapln1a-ECM and Sema3d during Fin Regeneration.";
RL PLoS ONE 11:e0148202-e0148202(2016).
RN [9] {ECO:0000313|RefSeq:NP_775327.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_775327.2};
RX PubMed=28207787;
RA Ouyang X., Panetta N.J., Talbott M.D., Payumo A.Y., Halluin C.,
RA Longaker M.T., Chen J.K.;
RT "Hyaluronic acid synthesis is required for zebrafish tail fin
RT regeneration.";
RL PLoS ONE 12:e0171898-e0171898(2017).
RN [10] {ECO:0000313|RefSeq:NP_775327.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_775327.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX950194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_775327.2; NM_173220.2.
DR STRING; 7955.ENSDARP00000074268; -.
DR PaxDb; 7955-ENSDARP00000074268; -.
DR Ensembl; ENSDART00000079817; ENSDARP00000074268; ENSDARG00000057210.
DR Ensembl; ENSDART00000079817.5; ENSDARP00000074268.3; ENSDARG00000057210.6.
DR GeneID; 282555; -.
DR KEGG; dre:282555; -.
DR AGR; ZFIN:ZDB-GENE-021118-1; -.
DR CTD; 3038; -.
DR ZFIN; ZDB-GENE-021118-1; has3.
DR OMA; LRKCLCS; -.
DR OrthoDB; 1361850at2759; -.
DR PhylomeDB; Q1LUE8; -.
DR TreeFam; TF332506; -.
DR Proteomes; UP000000437; Alternate scaffold 18.
DR Proteomes; UP000000437; Chromosome 18.
DR Bgee; ENSDARG00000057210; Expressed in heart and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; NAS:ZFIN.
DR GO; GO:0050501; F:hyaluronan synthase activity; ISS:ZFIN.
DR GO; GO:0085029; P:extracellular matrix assembly; IBA:GO_Central.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IBA:GO_Central.
DR GO; GO:0030213; P:hyaluronan biosynthetic process; ISS:ZFIN.
DR CDD; cd06434; GT2_HAS; 1.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22913; HYALURONAN SYNTHASE; 1.
DR PANTHER; PTHR22913:SF6; HYALURONAN SYNTHASE 3; 1.
DR Pfam; PF13641; Glyco_tranf_2_3; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 555 AA; 63318 MW; 2454B1AE16F5063F CRC64;
MPSRFGTAVR IFITTLFAAV VLFAILLAYV TGYQFIHTEQ HHLSFGLYGA FLSLHLLLQS
LFAYLEHRQM RGPSRPQHLR RTVALCIAAY QEDPDYLRKC LRSIRRISFP GLKVVLVVDG
NRQEDAYMMD IFQEVMGGVE QTGCVVWKGN YHSNGDGGGG GGKGSVHAEE AARVARVVRS
CRYSCIMQEW GGKREVMYTA FKALGDTVDY MQVCDSDTVL DPACTIEMLK ILEEDPDVGG
VGGDVQILNK YDSWISFLSS VRYWMAFNVE RACQSYFGCV QCISGPLGMY RNSLLQQFLE
PWYHQTFLGS KCSFGDDRHL TNRVLSFGFK TKFTARSQCQ TETPTQYLRW LNQQTRWSKS
YFREWLYNAL WFHKHSLWMT YESVVTGFFP FFLVATVIHL FYRGRLWNIL LFLLTVQLVG
MVKATYACFL RGSLVMIFMS LYSLLYMSSL LPAKIFALLT INKAGWGTSG RKKMVVNLIG
AVPVTVWTAI LLGGVVYTIY CEVQEPFTET EKALLIAGTI VYASYWLILL VLYLAIVAKR
CNKREEQFHL SYAEA
//
