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Database: UniProt
Entry: Q1LWF2_DANRE
LinkDB: Q1LWF2_DANRE
Original site: Q1LWF2_DANRE 
ID   Q1LWF2_DANRE            Unreviewed;       400 AA.
AC   Q1LWF2; A0A8M1N9Q7;
DT   30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT   30-MAY-2006, sequence version 1.
DT   24-JAN-2024, entry version 111.
DE   RecName: Full=ethanolamine kinase {ECO:0000256|ARBA:ARBA00038874};
DE            EC=2.7.1.82 {ECO:0000256|ARBA:ARBA00038874};
GN   Name=im:7143625 {ECO:0000313|RefSeq:NP_001038330.1};
GN   Synonyms=si:dkey-12e7.3 {ECO:0000313|RefSeq:NP_001038330.1},
GN   wu:fd46h01 {ECO:0000313|RefSeq:NP_001038330.1};
GN   OrderedLocusNames=chka {ECO:0000313|Ensembl:ENSDARP00000060014,
GN   ECO:0000313|RefSeq:NP_001038330.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-050208-149};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000060014};
RN   [1] {ECO:0000313|RefSeq:NP_001038330.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038330.1};
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.D., Sun X.J., Deng M., Zhang G.W., Zhou Y., Wu X.Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.L., Fan H.Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2] {ECO:0000313|RefSeq:NP_001038330.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038330.1};
RX   PubMed=23919627;
RA   Fu J., Han J., Zhou B., Gong Z., Santos E.M., Huo X., Zheng W., Liu H.,
RA   Yu H., Liu C.;
RT   "Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-
RT   2-propyl) phosphate (TDCPP) reveal possible molecular mechanisms of
RT   developmental toxicity.";
RL   Environ. Sci. Technol. 47:10574-10582(2013).
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000060014, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000060014};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000060014}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000060014};
RG   Ensembl;
RL   Submitted (AUG-2013) to UniProtKB.
RN   [5] {ECO:0000313|RefSeq:NP_001038330.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038330.1};
RX   PubMed=29339408;
RA   Chen T., Song G., Yang H., Mao L., Cui Z., Huang K.;
RT   "Development of the Swimbladder Surfactant System and Biogenesis of
RT   Lysosome-Related Organelles Is Regulated by BLOS1 in Zebrafish.";
RL   Genetics 208:1131-1146(2018).
RN   [6] {ECO:0000313|RefSeq:NP_001038330.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001038330.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC       biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
CC       {ECO:0000256|ARBA:ARBA00037883}.
CC   -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC       {ECO:0000256|ARBA:ARBA00038211}.
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DR   EMBL; BX571884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001038330.1; NM_001044865.1.
DR   Ensembl; ENSDART00000060015; ENSDARP00000060014; ENSDARG00000041078.
DR   Ensembl; ENSDART00000060015.8; ENSDARP00000060014.6; ENSDARG00000041078.8.
DR   GeneID; 558499; -.
DR   KEGG; dre:558499; -.
DR   CTD; 1119; -.
DR   ZFIN; ZDB-GENE-050208-149; chka.
DR   HOGENOM; CLU_012712_2_1_1; -.
DR   OrthoDB; 144299at2759; -.
DR   Proteomes; UP000000437; Alternate scaffold 18.
DR   Proteomes; UP000000437; Chromosome 18.
DR   Bgee; ENSDARG00000041078; Expressed in head kidney and 22 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004103; F:choline kinase activity; IBA:GO_Central.
DR   GO; GO:0004305; F:ethanolamine kinase activity; IBA:GO_Central.
DR   GO; GO:0006657; P:CDP-choline pathway; IBA:GO_Central.
DR   GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05156; ChoK_euk; 1.
DR   Gene3D; 3.90.1200.10; -; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   PANTHER; PTHR22603:SF36; CHOLINE KINASE ALPHA; 1.
DR   PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR   Pfam; PF01633; Choline_kinase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|RefSeq:NP_001038330.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transferase {ECO:0000313|RefSeq:NP_001038330.1}.
SQ   SEQUENCE   400 AA;  46577 MW;  93F7D9C69DF0FF2A CRC64;
     MKTKFINGVS SSPSMSLGLL VNESVLEVQP DSVNDCKDII RPDEPDQQTK HKAYLWCREF
     LHGAWKSIDE EDFQISIIRG GLSNKLFLCA LPEMQASLGD EPRNVLLRLY GEILQGADAM
     VLESVMFAIL AERELGPKLY GIFPQGRLEQ FVPSRKLTTD ELSVPGINAE IAEKIARFHG
     MRMPFNKEPK WLFGTMEKYM DQVLQLTFTR EPHLRNFSRI LSYNLPQEMD NLKCLLESTP
     SPVVFCHNDL QEGNILLLNG RENTDRQRLM LIDFEYSSYN YRGFDIGNFF CEWTYDYTYD
     KFPFFTNNTK NYPTKAQQMH IFHSYLLESD AGFKHLSEED QMKLKEDMLV EVNRFALASH
     FFWGLWSMIQ AKISTIEFGY MEYAMARFDA YFELKRKLGV
//
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