ID PAX6_BOVIN Reviewed; 422 AA.
AC Q1LZF1;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 01-MAY-2013, entry version 61.
DE RecName: Full=Paired box protein Pax-6;
DE AltName: Full=Oculorhombin;
GN Name=PAX6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC Pecora; Bovidae; Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor with important functions in the
CC development of the eye, nose, central nervous system and pancreas.
CC Required for the differentiation of pancreatic islet alpha cells.
CC Competes with PAX4 in binding to a common element in the glucagon,
CC insulin and somatostatin promoters. Regulates specification of the
CC ventral neuron subtypes by establishing the correct progenitor
CC domains (By similarity).
CC -!- SUBUNIT: Interacts with MAF and MAFB (By similarity). Interacts
CC with TRIM11; this interaction leads to ubiquitination and
CC proteasomal degradation, as well as inhibition of transactivation,
CC possibly in part by preventing PAX6 binding to consensus DNA
CC sequences (By similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC -!- PTM: Ubiquitinated by TRIM11, leading to ubiquitination and
CC proteasomal degradation (By similarity).
CC -!- SIMILARITY: Belongs to the paired homeobox family.
CC -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
CC -!- SIMILARITY: Contains 1 paired domain.
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DR EMBL; BC116038; AAI16039.1; -; mRNA.
DR IPI; IPI00686718; -.
DR RefSeq; NP_001035735.1; NM_001040645.1.
DR UniGene; Bt.11759; -.
DR ProteinModelPortal; Q1LZF1; -.
DR SMR; Q1LZF1; 4-136, 211-278.
DR PRIDE; Q1LZF1; -.
DR Ensembl; ENSBTAT00000005994; ENSBTAP00000005994; ENSBTAG00000004561.
DR GeneID; 286857; -.
DR KEGG; bta:286857; -.
DR CTD; 5080; -.
DR eggNOG; NOG326044; -.
DR GeneTree; ENSGT00680000099553; -.
DR HOGENOM; HOG000230939; -.
DR HOVERGEN; HBG009115; -.
DR InParanoid; Q1LZF1; -.
DR KO; K08031; -.
DR OMA; NGQTGTW; -.
DR OrthoDB; EOG47PX63; -.
DR NextBio; 20806506; -.
DR ArrayExpress; Q1LZF1; -.
DR GO; GO:0005737; C:cytoplasm; IEA:Compara.
DR GO; GO:0000790; C:nuclear chromatin; IEA:Compara.
DR GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Compara.
DR GO; GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:Compara.
DR GO; GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
DR GO; GO:0048708; P:astrocyte differentiation; IEA:Compara.
DR GO; GO:0007411; P:axon guidance; IEA:Compara.
DR GO; GO:0001568; P:blood vessel development; IEA:Compara.
DR GO; GO:0001709; P:cell fate determination; IEA:Compara.
DR GO; GO:0021796; P:cerebral cortex regionalization; IEA:Compara.
DR GO; GO:0021902; P:commitment of neuronal cell to specific neuron type in forebrain; IEA:Compara.
DR GO; GO:0061303; P:cornea development in camera-type eye; IEA:Compara.
DR GO; GO:0009950; P:dorsal/ventral axis specification; IEA:Compara.
DR GO; GO:0048596; P:embryonic camera-type eye morphogenesis; IEA:Compara.
DR GO; GO:0042462; P:eye photoreceptor cell development; IEA:Compara.
DR GO; GO:0021797; P:forebrain anterior/posterior pattern specification; IEA:Compara.
DR GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IEA:Compara.
DR GO; GO:0021905; P:forebrain-midbrain boundary formation; IEA:Compara.
DR GO; GO:0042593; P:glucose homeostasis; IEA:Compara.
DR GO; GO:0061072; P:iris morphogenesis; IEA:Compara.
DR GO; GO:0030216; P:keratinocyte differentiation; IEA:Compara.
DR GO; GO:0032808; P:lacrimal gland development; IEA:Compara.
DR GO; GO:0002088; P:lens development in camera-type eye; IEA:Compara.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Compara.
DR GO; GO:0050768; P:negative regulation of neurogenesis; ISS:UniProtKB.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Compara.
DR GO; GO:0001764; P:neuron migration; IEA:Compara.
DR GO; GO:0021778; P:oligodendrocyte cell fate specification; IEA:Compara.
DR GO; GO:0003322; P:pancreatic A cell development; IEA:Compara.
DR GO; GO:0021983; P:pituitary gland development; IEA:Compara.
DR GO; GO:0030858; P:positive regulation of epithelial cell differentiation; IEA:Compara.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Compara.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
DR GO; GO:0033365; P:protein localization to organelle; IEA:Compara.
DR GO; GO:0030334; P:regulation of cell migration; IEA:Compara.
DR GO; GO:0048505; P:regulation of timing of cell differentiation; IEA:Compara.
DR GO; GO:0021918; P:regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment; IEA:Compara.
DR GO; GO:0021912; P:regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; IEA:Compara.
DR GO; GO:0021913; P:regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; IEA:Compara.
DR GO; GO:0009611; P:response to wounding; IEA:Compara.
DR GO; GO:0007435; P:salivary gland morphogenesis; IEA:Compara.
DR GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IEA:Compara.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Compara.
DR Gene3D; 1.10.10.10; -; 2.
DR Gene3D; 1.10.10.60; -; 1.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeodomain.
DR InterPro; IPR009057; Homeodomain-like.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00046; Homeobox; 1.
DR Pfam; PF00292; PAX; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; Homeodomain_like; 2.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Developmental protein; Differentiation;
KW DNA-binding; Homeobox; Nucleus; Paired box; Reference proteome;
KW Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1 422 Paired box protein Pax-6.
FT /FTId=PRO_0000263070.
FT DOMAIN 4 130 Paired.
FT DNA_BIND 210 269 Homeobox.
FT COMPBIAS 131 209 Gln/Gly-rich.
FT COMPBIAS 279 422 Pro/Ser/Thr-rich.
SQ SEQUENCE 422 AA; 46653 MW; B5E7AD2C1B13C383 CRC64;
MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQVSN GCVSKILGRY
YETGSIRPRA IGGSKPRVAT PEVVSKIAQY KRECPSIFAW EIRDRLLSEG VCTNDNIPSV
SSINRVLRNL ASEKQQMGAD GMYDKLRMLN GQTGSWGTRP GWYPGTSVPG QPTQDGCQQQ
EGGGENTNSI SSNGEDSDEA QMRLQLKRKL QRNRTSFTQE QIEALEKEFE RTHYPDVFAR
ERLAAKIDLP EARIQVWFSN RRAKWRREEK LRNQRRQASN TPSHIPISSS FSTSVYQPIP
QPTTPVSSFT SGSMLGRTDT ALTNTYSALP PMPSFTMANN LPMQPPVPSQ TSSYSCMLPT
SPSVNGRSYD TYTPPHMQTH MNSQPMGTSG ATSTGLISPG VSVPVQVPGS EPDMSQYWPR
LQ
//
