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Database: UniProt
Entry: Q1LZF1
LinkDB: Q1LZF1
Original site: Q1LZF1 
ID   PAX6_BOVIN              Reviewed;         422 AA.
AC   Q1LZF1;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   01-OCT-2014, entry version 69.
DE   RecName: Full=Paired box protein Pax-6;
DE   AltName: Full=Oculorhombin;
GN   Name=PAX6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor with important functions in the
CC       development of the eye, nose, central nervous system and pancreas.
CC       Required for the differentiation of pancreatic islet alpha cells.
CC       Competes with PAX4 in binding to a common element in the glucagon,
CC       insulin and somatostatin promoters. Regulates specification of the
CC       ventral neuron subtypes by establishing the correct progenitor
CC       domains (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with MAF and MAFB. Interacts with TRIM11; this
CC       interaction leads to ubiquitination and proteasomal degradation,
CC       as well as inhibition of transactivation, possibly in part by
CC       preventing PAX6 binding to consensus DNA sequences. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
CC       ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00381}.
CC   -!- PTM: Ubiquitinated by TRIM11, leading to ubiquitination and
CC       proteasomal degradation. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Contains 1 paired domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00381}.
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DR   EMBL; BC116038; AAI16039.1; -; mRNA.
DR   RefSeq; NP_001035735.1; NM_001040645.1.
DR   UniGene; Bt.11759; -.
DR   ProteinModelPortal; Q1LZF1; -.
DR   SMR; Q1LZF1; 4-136, 211-278.
DR   PRIDE; Q1LZF1; -.
DR   Ensembl; ENSBTAT00000005994; ENSBTAP00000005994; ENSBTAG00000004561.
DR   GeneID; 286857; -.
DR   KEGG; bta:286857; -.
DR   CTD; 5080; -.
DR   eggNOG; NOG326044; -.
DR   GeneTree; ENSGT00680000099553; -.
DR   HOGENOM; HOG000230939; -.
DR   HOVERGEN; HBG009115; -.
DR   InParanoid; Q1LZF1; -.
DR   KO; K08031; -.
DR   OMA; AGENTNS; -.
DR   OrthoDB; EOG7WT431; -.
DR   TreeFam; TF320146; -.
DR   Reactome; REACT_206064; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
DR   Reactome; REACT_213705; Regulation of gene expression in early pancreatic precursor cells.
DR   Reactome; REACT_225796; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
DR   Reactome; REACT_226927; Regulation of gene expression in beta cells.
DR   NextBio; 20806506; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:Ensembl.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
DR   GO; GO:0048708; P:astrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR   GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR   GO; GO:0001709; P:cell fate determination; IEA:Ensembl.
DR   GO; GO:0021796; P:cerebral cortex regionalization; IEA:Ensembl.
DR   GO; GO:0021902; P:commitment of neuronal cell to specific neuron type in forebrain; IEA:Ensembl.
DR   GO; GO:0061303; P:cornea development in camera-type eye; IEA:Ensembl.
DR   GO; GO:0009950; P:dorsal/ventral axis specification; IEA:Ensembl.
DR   GO; GO:0048596; P:embryonic camera-type eye morphogenesis; IEA:Ensembl.
DR   GO; GO:0042462; P:eye photoreceptor cell development; IEA:Ensembl.
DR   GO; GO:0021797; P:forebrain anterior/posterior pattern specification; IEA:Ensembl.
DR   GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IEA:Ensembl.
DR   GO; GO:0021905; P:forebrain-midbrain boundary formation; IEA:Ensembl.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0061072; P:iris morphogenesis; IEA:Ensembl.
DR   GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR   GO; GO:0032808; P:lacrimal gland development; IEA:Ensembl.
DR   GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
DR   GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0050768; P:negative regulation of neurogenesis; ISS:UniProtKB.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR   GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR   GO; GO:0021778; P:oligodendrocyte cell fate specification; IEA:Ensembl.
DR   GO; GO:0003322; P:pancreatic A cell development; IEA:Ensembl.
DR   GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
DR   GO; GO:0030858; P:positive regulation of epithelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0033365; P:protein localization to organelle; IEA:Ensembl.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:GOC.
DR   GO; GO:0030334; P:regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0048505; P:regulation of timing of cell differentiation; IEA:Ensembl.
DR   GO; GO:0021918; P:regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment; IEA:Ensembl.
DR   GO; GO:0021912; P:regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; IEA:Ensembl.
DR   GO; GO:0021913; P:regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; IEA:Ensembl.
DR   GO; GO:0009611; P:response to wounding; IEA:Ensembl.
DR   GO; GO:0007435; P:salivary gland morphogenesis; IEA:Ensembl.
DR   GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR   GO; GO:0003309; P:type B pancreatic cell differentiation; IEA:Ensembl.
DR   Gene3D; 1.10.10.10; -; 2.
DR   Gene3D; 1.10.10.60; -; 1.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR009057; Homeodomain-like.
DR   InterPro; IPR001523; Paired_dom.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00046; Homeobox; 1.
DR   Pfam; PF00292; PAX; 1.
DR   PRINTS; PR00027; PAIREDBOX.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00351; PAX; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00034; PAIRED_1; 1.
DR   PROSITE; PS51057; PAIRED_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Developmental protein; Differentiation;
KW   DNA-binding; Homeobox; Nucleus; Paired box; Reference proteome;
KW   Transcription; Transcription regulation; Ubl conjugation.
FT   CHAIN         1    422       Paired box protein Pax-6.
FT                                /FTId=PRO_0000263070.
FT   DOMAIN        4    130       Paired. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00381}.
FT   DNA_BIND    210    269       Homeobox. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00108}.
FT   COMPBIAS    131    209       Gln/Gly-rich.
FT   COMPBIAS    279    422       Pro/Ser/Thr-rich.
SQ   SEQUENCE   422 AA;  46653 MW;  B5E7AD2C1B13C383 CRC64;
     MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQVSN GCVSKILGRY
     YETGSIRPRA IGGSKPRVAT PEVVSKIAQY KRECPSIFAW EIRDRLLSEG VCTNDNIPSV
     SSINRVLRNL ASEKQQMGAD GMYDKLRMLN GQTGSWGTRP GWYPGTSVPG QPTQDGCQQQ
     EGGGENTNSI SSNGEDSDEA QMRLQLKRKL QRNRTSFTQE QIEALEKEFE RTHYPDVFAR
     ERLAAKIDLP EARIQVWFSN RRAKWRREEK LRNQRRQASN TPSHIPISSS FSTSVYQPIP
     QPTTPVSSFT SGSMLGRTDT ALTNTYSALP PMPSFTMANN LPMQPPVPSQ TSSYSCMLPT
     SPSVNGRSYD TYTPPHMQTH MNSQPMGTSG ATSTGLISPG VSVPVQVPGS EPDMSQYWPR
     LQ
//
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