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Database: UniProt
Entry: Q1MKI5
LinkDB: Q1MKI5
Original site: Q1MKI5 
ID   COXX_RHIL3              Reviewed;         316 AA.
AC   Q1MKI5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-SEP-2014, entry version 58.
DE   RecName: Full=Protoheme IX farnesyltransferase;
DE            EC=2.5.1.-;
DE   AltName: Full=Heme B farnesyltransferase;
DE   AltName: Full=Heme O synthase;
GN   Name=ctaB; Synonyms=coxX; OrderedLocusNames=RL1023;
OS   Rhizobium leguminosarum bv. viciae (strain 3841).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=216596;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3841;
RX   PubMed=16640791; DOI=10.1186/gb-2006-7-4-r34;
RA   Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R.,
RA   Ghazoui Z.F., Hull K.H., Wexler M., Curson A.R.J., Todd J.D.,
RA   Poole P.S., Mauchline T.H., East A.K., Quail M.A., Churcher C.,
RA   Arrowsmith C., Cherevach I., Chillingworth T., Clarke K., Cronin A.,
RA   Davis P., Fraser A., Hance Z., Hauser H., Jagels K., Moule S.,
RA   Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA   Whitehead S., Parkhill J.;
RT   "The genome of Rhizobium leguminosarum has recognizable core and
RT   accessory components.";
RL   Genome Biol. 7:R34.1-R34.20(2006).
CC   -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC       of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC       hydroxyethyl farnesyl side group (By similarity).
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; heme O
CC       biosynthesis; heme O from protoheme: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC       protein (Potential).
CC   -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC       according to the Fischer nomenclature (By similarity).
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       Protoheme IX farnesyltransferase subfamily.
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DR   EMBL; AM236080; CAK06520.1; -; Genomic_DNA.
DR   RefSeq; WP_011650758.1; NC_008380.1.
DR   RefSeq; YP_766634.1; NC_008380.1.
DR   STRING; 216596.RL1023; -.
DR   EnsemblBacteria; CAK06520; CAK06520; RL1023.
DR   GeneID; 4402422; -.
DR   KEGG; rle:RL1023; -.
DR   PATRIC; 23138489; VBIRhiLeg32091_2189.
DR   eggNOG; COG0109; -.
DR   HOGENOM; HOG000237291; -.
DR   KO; K02301; -.
DR   OMA; LFKMRDY; -.
DR   OrthoDB; EOG6DVJQB; -.
DR   BioCyc; RLEG216596:GKE5-1052-MONOMER; -.
DR   UniPathway; UPA00834; UER00712.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00154; CyoE_CtaB; 1.
DR   InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome;
KW   Heme biosynthesis; Membrane; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    316       Protoheme IX farnesyltransferase.
FT                                /FTId=PRO_0000327130.
FT   TRANSMEM     32     52       Helical; (Potential).
FT   TRANSMEM     53     73       Helical; (Potential).
FT   TRANSMEM     93    113       Helical; (Potential).
FT   TRANSMEM    116    136       Helical; (Potential).
FT   TRANSMEM    152    172       Helical; (Potential).
FT   TRANSMEM    180    200       Helical; (Potential).
FT   TRANSMEM    221    241       Helical; (Potential).
FT   TRANSMEM    252    271       Helical; (Potential).
FT   TRANSMEM    289    309       Helical; (Potential).
SQ   SEQUENCE   316 AA;  33811 MW;  CD09B64A7BADDCA2 CRC64;
     MTVIDNHGVL AKDGELSEAS ARDYFELLKP RVMSLVVFTA FAGLVLAPGH IHPVLGTIAI
     LCIAVGAGAS GALNMWYDAD IDAIMSRTAN RPIPAGRIAP SEALAFGLVL SGFSVVILGL
     AVNWLSAGIL AFTIFFYAVV YTMWLKRSTP QNIVIGGAAG AFPPMIGWAC VTNSVTIEST
     VLFLIIFLWT PAHFWALALF KMRDYEAVGV PMLPNVAGER VTKHQIVAYA VLTAVCAVLP
     SFLGFASLGY GLVAAALGAI FIYCSIAVWR MPDGDLKMIP AKKLFGFSIF YLFAVFSALM
     IDRLAPVLVS HAGGWF
//
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