ID Q1MR72_LAWIP Unreviewed; 274 AA.
AC Q1MR72;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain {ECO:0000313|EMBL:CAJ54504.1};
GN Name=purL {ECO:0000313|EMBL:CAJ54504.1};
GN OrderedLocusNames=LI0450 {ECO:0000313|EMBL:CAJ54504.1};
OS Lawsonia intracellularis (strain PHE/MN1-00).
OC Bacteria; Thermodesulfobacteriota; Desulfovibrionia; Desulfovibrionales;
OC Desulfovibrionaceae; Lawsonia.
OX NCBI_TaxID=363253 {ECO:0000313|EMBL:CAJ54504.1, ECO:0000313|Proteomes:UP000002430};
RN [1] {ECO:0000313|EMBL:CAJ54504.1, ECO:0000313|Proteomes:UP000002430}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHE/MN1-00 {ECO:0000313|EMBL:CAJ54504.1,
RC ECO:0000313|Proteomes:UP000002430};
RA Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L.,
RA Peterson A., May B., Singh S., Gebhart C., Kapur V.;
RT "The complete genome sequence of Lawsonia intracellularis: the causative
RT agent of proliferative enteropathy.";
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM180252; CAJ54504.1; -; Genomic_DNA.
DR RefSeq; WP_011526534.1; NC_008011.1.
DR AlphaFoldDB; Q1MR72; -.
DR STRING; 363253.LI0450; -.
DR KEGG; lip:LI0450; -.
DR eggNOG; COG0047; Bacteria.
DR HOGENOM; CLU_001031_3_0_7; -.
DR OrthoDB; 9804441at2; -.
DR Proteomes; UP000002430; Chromosome.
DR GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:InterPro.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR010075; PRibForGlyAmidine_synth_PurQ.
DR PANTHER; PTHR10099; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR PANTHER; PTHR10099:SF1; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR Pfam; PF13507; GATase_5; 1.
DR PIRSF; PIRSF001586; FGAM_synth_I; 1.
DR SMART; SM01211; GATase_5; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 4: Predicted;
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605};
KW Reference proteome {ECO:0000313|Proteomes:UP000002430}.
FT ACT_SITE 104
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 236
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 238
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 274 AA; 30093 MW; 9D0EF1496E0B083F CRC64;
MAQVNALVIT GYGTNSHNET AHAIRLAGAD YVDIKHFSEV VAAEVFLDSY QLLVFPGGFL
DGDDLGAAQA AAQRWRYLSD KNGVSLLTSL KNFIAKGGLV LGICNGFQLL VKLGMLPSLD
GKLFDRQVSL SHNDSARFED RWVSLRVNQD SPCVFTRGLS EKNLLSMPVR HGEGKCIVRE
PSILQQLIDG QHIVLQYADP TTGEATQEYP YNPNGSPFAI AGLTDTSGRI FGLMPHPEAF
HHRTNHPGWP RGEQTILGTI IFQNAVDFCR TIDK
//
