ID Q1MST6_HBV Unreviewed; 173 AA.
AC Q1MST6;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=External core antigen {ECO:0000256|RuleBase:RU361253};
DE Flags: Fragment;
GN Name=preC/C {ECO:0000313|EMBL:CAJ33921.1};
GN Synonyms=C {ECO:0000256|RuleBase:RU361253};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:CAJ33921.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:CAJ33921.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MAL75 {ECO:0000313|EMBL:CAJ33921.1};
RX PubMed=16603517; DOI=10.1099/vir.0.81614-0;
RA Olinger C.M., Venard V., Njayou M., Oyefolu A.O., Maiga I., Kemp A.J.,
RA Omilabu S.A., le Faou A., Muller C.P.;
RT "Phylogenetic analysis of the precore/core gene of hepatitis B virus
RT genotypes E and A in West Africa: new subtypes, mixed infections and
RT recombinations.";
RL J. Gen. Virol. 87:1163-1173(2006).
CC -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC acting as a T-cell tolerogen, by having an immunoregulatory effect
CC which prevents destruction of infected cells by cytotoxic T-cells.
CC {ECO:0000256|RuleBase:RU361253}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361253}.
CC -!- PTM: Cleaved by host furin. {ECO:0000256|RuleBase:RU361253}.
CC -!- PTM: Phosphorylated. {ECO:0000256|RuleBase:RU361253}.
CC -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC {ECO:0000256|RuleBase:RU361253}.
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DR EMBL; AM110823; CAJ33921.1; -; Genomic_DNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.4090.10; Viral capsid, core domain supefamily, Hepatitis B virus; 1.
DR InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR InterPro; IPR002006; Hepatitis_core.
DR InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR Pfam; PF08290; Hep_core_N; 1.
DR Pfam; PF00906; Hepatitis_core; 2.
DR SUPFAM; SSF47852; Hepatitis B viral capsid (hbcag); 1.
PE 3: Inferred from homology;
KW Host-virus interaction {ECO:0000256|RuleBase:RU361253};
KW Viral immunoevasion {ECO:0000256|RuleBase:RU361253}.
FT DOMAIN 1..27
FT /note="Hepatitis B virus capsid N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08290"
FT NON_TER 173
FT /evidence="ECO:0000313|EMBL:CAJ33921.1"
SQ SEQUENCE 173 AA; 19507 MW; 2D3E5771668EB3EA CRC64;
MQLFHLCLII SCSCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPS DFFPSVRDLL
DTASALYRDA LESPEHCSPH HTALRQAILC WGELMTLATW VGVNLEDPAS RDLVVSYVNT
NMGLKFRQLL WFHISCLTFG KETVIEYLVS FGVWIRTPPA YRPPNAPILS TLP
//
