GenomeNet

Database: UniProt
Entry: Q1MTB2_DANRE
LinkDB: Q1MTB2_DANRE
Original site: Q1MTB2_DANRE 
ID   Q1MTB2_DANRE            Unreviewed;      1214 AA.
AC   Q1MTB2;
DT   30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 3.
DT   25-OCT-2017, entry version 81.
DE   SubName: Full=Transient receptor potential cation channel, subfamily M, member 5 {ECO:0000313|Ensembl:ENSDARP00000077908};
GN   Name=trpm5 {ECO:0000313|Ensembl:ENSDARP00000077908,
GN   ECO:0000313|ZFIN:ZDB-GENE-060503-736};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000077908, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000077908, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000077908,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000077908}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000077908};
RG   Ensembl;
RL   Submitted (AUG-2013) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000077908}.
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DR   EMBL; AL928843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL929208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7955.ENSDARP00000077908; -.
DR   PaxDb; Q1MTB2; -.
DR   Ensembl; ENSDART00000083473; ENSDARP00000077908; ENSDARG00000059792.
DR   ZFIN; ZDB-GENE-060503-736; trpm5.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   HOGENOM; HOG000236350; -.
DR   HOVERGEN; HBG108337; -.
DR   InParanoid; Q1MTB2; -.
DR   PhylomeDB; Q1MTB2; -.
DR   TreeFam; TF314204; -.
DR   Reactome; R-DRE-3295583; TRP channels.
DR   Proteomes; UP000000437; Chromosome 7.
DR   Bgee; ENSDARG00000059792; -.
DR   ExpressionAtlas; Q1MTB2; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IEA:InterPro.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR002153; TRPC_channel.
DR   InterPro; IPR029577; TRPM5.
DR   PANTHER; PTHR13800:SF5; PTHR13800:SF5; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    761    784       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    909    930       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    990   1015       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      776   1029       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1214 AA;  137922 MW;  D6C564934590F367 CRC64;
     MLGNQDTPLG VLRQGRRCVQ CGELMYESQG YSSLVGCRCY TPLTQSVVSM VEKSSERFDK
     QMAGRLGDID FTGVSRTRGK FVRVTSSTDP AEIYQILTKQ WGLAPPHLVV ALMGGDEVAQ
     LKPWLRDTLR KGLVKAAQST GAWILTSGLR FGITKNLGQA VRDHSLASTS PKVRVVAIGI
     APWNMIQNRD LLLSAKPDHP ATYPTEDLPY GAVYSLDCNH SHFILVDEDP KRPGATGEMR
     VKMLKHISLQ RTGYGGTGSI EIPVLCLLVH GEPRILQKMY KNIQNSIPWL ILAGSGGVAD
     ILVTLMDRGC WDADIVQELL INTFPDGLHS TEITSWTKLI QRILDHGHLL TVHDPEQDSE
     LDTVILKALV KACKSQSQEA QDFLDELKLA VAWNRVDIAK SEIFSGDVQW SAQDLEEVMM
     EALVNDKPDF VRLFVDNGVN IKQFLTYGRL QELYCSVSEK NLLHTLLLKK NQERQAQLAR
     KRMSGNPNNE LGDRKFRFTF HEVSKVLKDF LDDTCKGFYQ KLPAERMGKG RLFHSQKNLP
     DMDRRCEHPW RDLFLWAILQ NRQEMANYFW AMGPEAVAAA LVGCKIMKEM AHLATEAESA
     RSMKNAKYEQ FAMDLFSECY SNSEDRAYSL LVRKTCCWSK ATVLNIATLA EAKCFFAHDG
     VQALLTKVWW GAMRTDTSIS RLVLTFFIPP LVWTSLIKFN PEEQVSKDEG EPFAELDSLE
     TEQALLLTDG DPVAGEGSAE TAARSCSATF IRVVLRRWNR FWSAPVTVFM GNVIMYFAFL
     ILFSYVLLLD FRPPPPYGPS AAEIILYFWV FTLVLEEIRQ SFFTDEDMSI LKKMKLYVED
     NWNKCDMVAI SLFVVGLSCR MAMSTYEAGR TVLALDFMVF TLRLIHIFAI HKQLGPKIII
     VERMIKDVFF FLFFLSVWLI AYGVTTQALL HPNDPRIDWV FRRALYRPYL HIFGQIPLEE
     IDAAKMPDDN CTTDVQEIIL GTLPPCPNIY ANWLVILLLV IYLLVTNVLL LNLLIAMFSY
     TFQVVQENAD IFWKFQRYNL IVEYHSRPAL APPFIIISHI TQALLSFIKK TENTQDLLGK
     ELPSGLDQKL MTWETVQKEN YLAKLEHEHR ESSGERLRYT SSKVQTLLRM VGGFKDQEKR
     MATVETEVRY CGEVLSWIAE CFHKSTLKCD RDAPKAPRSI AGSSRDQQPQ GAKRQQPAGH
     PAYGTDKKLP FIDH
//
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