ID GLPK_NITHX Reviewed; 503 AA.
AC Q1QR91;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 01-MAY-2013, entry version 52.
DE RecName: Full=Glycerol kinase;
DE EC=2.7.1.30;
DE AltName: Full=ATP:glycerol 3-phosphotransferase;
DE AltName: Full=Glycerokinase;
DE Short=GK;
GN Name=glpK; OrderedLocusNames=Nham_0360;
OS Nitrobacter hamburgensis (strain X14 / DSM 10229).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Bradyrhizobiaceae; Nitrobacter.
OX NCBI_TaxID=323097;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=X14 / DSM 10229;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Ward B.,
RA Arp D., Klotz M., Stein L., O'Mullan G., Starkenburg S., Sayavedra L.,
RA Poret-Peterson A.T., Gentry M.E., Bruce D., Richardson P.;
RT "Complete sequence of chromosome of Nitrobacter hamburgensis X14.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key enzyme in the regulation of glycerol uptake and
CC metabolism (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3-
CC phosphate.
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol
CC kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
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DR EMBL; CP000319; ABE61256.1; -; Genomic_DNA.
DR RefSeq; YP_575716.1; NC_007964.1.
DR ProteinModelPortal; Q1QR91; -.
DR SMR; Q1QR91; 5-492.
DR STRING; 323097.Nham_0360; -.
DR EnsemblBacteria; ABE61256; ABE61256; Nham_0360.
DR GeneID; 4030246; -.
DR KEGG; nha:Nham_0360; -.
DR PATRIC; 22688099; VBINitHam61822_1087.
DR eggNOG; COG0554; -.
DR HOGENOM; HOG000222134; -.
DR KO; K00864; -.
DR OMA; GQKEFTQ; -.
DR ProtClustDB; CLSK818559; -.
DR BioCyc; NHAM323097:GHP7-428-MONOMER; -.
DR UniPathway; UPA00618; UER00672.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:HAMAP.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:HAMAP.
DR HAMAP; MF_00186; Glycerol_kin; 1; -.
DR InterPro; IPR018485; Carb_kinase_FGGY_C.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018484; Carb_kinase_FGGY_N.
DR InterPro; IPR005999; Glycerol_kin.
DR PANTHER; PTHR10196:SF9; PTHR10196:SF9; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR TIGRFAMs; TIGR01311; glycerol_kin; 1.
DR PROSITE; PS00933; FGGY_KINASES_1; FALSE_NEG.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Glycerol metabolism; Kinase;
KW Nucleotide-binding; Transferase.
FT CHAIN 1 503 Glycerol kinase.
FT /FTId=PRO_1000020752.
FT NP_BIND 412 416 ATP (By similarity).
FT BINDING 12 12 Substrate (By similarity).
FT BINDING 16 16 ATP (By similarity).
FT BINDING 82 82 Substrate (By similarity).
FT BINDING 134 134 Substrate (By similarity).
FT BINDING 243 243 Substrate (By similarity).
FT BINDING 265 265 ATP (By similarity).
FT BINDING 308 308 ATP; via carbonyl oxygen (By similarity).
SQ SEQUENCE 503 AA; 53996 MW; E41C9C995FC5FCFD CRC64;
MVTHVLAIDQ GTTSSRAILF RADTSIAAIA QQEFPQHFPA SGWVEHEPED IWTSTVATCR
EAMNKAGVTP KDIAAIGITN QRETTVVWDR ATGQAMHRAV VWQDRRTADI CARLKAEGHE
PAISAKTGLI VDPYFSGTKI AWILDSVPGA RARASRGDLL FGTVDCYLLW RLTGGKVHAT
DATNASRTLL FDIHTGQWDE ELLKILRVPR AMLPEVKDSS AHFGDSVADL FGAPISIRGI
AGDQQAAVVG QACFAPGMIK STYGTGCFAL LNTGATPVAS KNKLLTTIAY QLNGKRTYAL
EGSIFVAGSA VQWLRDGLGL IKQASETGPL ADRSDATQSV YLVPAFVGMG APYWNPNVRG
ALFGLTRNTG PAELAHAALE SVCYQTFDLW AAMRADWPDA AAAHTVLRVD GGMTASDWTM
QRLADLLDAP VDRPVIQETT ALGAAYLAGL SAGVYPEPSK FADNWRLERR FKPAMSAATR
TRKLKGWAAA VRGVLASDGG EGR
//
