ID GPDA_CHRSD Reviewed; 356 AA.
AC Q1QUM1;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 01-MAY-2013, entry version 61.
DE RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(P)+];
DE EC=1.1.1.94;
DE AltName: Full=NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
GN Name=gpsA; OrderedLocusNames=Csal_2490;
OS Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB
OS 13768).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Chromohalobacter.
OX NCBI_TaxID=290398;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3043 / ATCC BAA-138 / NCIMB 13768;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T.,
RA Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N.,
RA O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R.,
RA Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D.,
RA Canovas D., Richardson P.;
RT "Complete sequence of Chromohalobacter salexigens DSM 3043.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + NAD(P)(+) =
CC glycerone phosphate + NAD(P)H.
CC -!- PATHWAY: Membrane lipid metabolism; glycerophospholipid
CC metabolism.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the NAD-dependent glycerol-3-phosphate
CC dehydrogenase family.
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DR EMBL; CP000285; ABE59837.1; -; Genomic_DNA.
DR RefSeq; YP_574536.1; NC_007963.1.
DR ProteinModelPortal; Q1QUM1; -.
DR STRING; 290398.Csal_2490; -.
DR EnsemblBacteria; ABE59837; ABE59837; Csal_2490.
DR GeneID; 4026628; -.
DR KEGG; csa:Csal_2490; -.
DR PATRIC; 21448828; VBIChrSal113723_2502.
DR eggNOG; COG0240; -.
DR HOGENOM; HOG000246854; -.
DR KO; K00057; -.
DR OMA; VARNCNN; -.
DR ProtClustDB; PRK00094; -.
DR UniPathway; UPA00940; -.
DR GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
DR GO; GO:0047952; F:glycerol-3-phosphate dehydrogenase [NAD(P)+] activity; IEA:HAMAP.
DR GO; GO:0004367; F:glycerol-3-phosphate dehydrogenase [NAD+] activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0046167; P:glycerol-3-phosphate biosynthetic process; IEA:HAMAP.
DR GO; GO:0046168; P:glycerol-3-phosphate catabolic process; IEA:InterPro.
DR GO; GO:0006650; P:glycerophospholipid metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:HAMAP.
DR Gene3D; 1.10.1040.10; -; 1.
DR Gene3D; 3.40.50.720; -; 1.
DR HAMAP; MF_00394; NAD_Glyc3P_dehydrog; 1; -.
DR InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR InterPro; IPR013328; DH_multihelical.
DR InterPro; IPR006168; G3P_DH_NAD-dep.
DR InterPro; IPR006109; G3P_DH_NAD-dep_C.
DR InterPro; IPR011128; G3P_DH_NAD-dep_N.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR PANTHER; PTHR11728; PTHR11728; 1.
DR Pfam; PF07479; NAD_Gly3P_dh_C; 1.
DR Pfam; PF01210; NAD_Gly3P_dh_N; 1.
DR PIRSF; PIRSF000114; Glycerol-3-P_dh; 1.
DR PRINTS; PR00077; GPDHDRGNASE.
DR SUPFAM; SSF48179; 6DGDH_C_like; 1.
DR PROSITE; PS00957; NAD_G3PDH; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Lipid biosynthesis; Lipid metabolism;
KW NAD; Oxidoreductase; Phospholipid biosynthesis;
KW Phospholipid metabolism.
FT CHAIN 1 356 Glycerol-3-phosphate dehydrogenase
FT [NAD(P)+].
FT /FTId=PRO_0000255299.
FT NP_BIND 12 17 NAD (By similarity).
FT REGION 257 258 Substrate binding (By similarity).
FT ACT_SITE 193 193 Proton acceptor (By similarity).
FT BINDING 110 110 NAD; via amide nitrogen (By similarity).
FT BINDING 110 110 Substrate (By similarity).
FT BINDING 142 142 NAD; via amide nitrogen (By similarity).
FT BINDING 257 257 NAD (By similarity).
FT BINDING 283 283 NAD (By similarity).
SQ SEQUENCE 356 AA; 38575 MW; FA7B28E2F3024B69 CRC64;
MTDERPKVAV LGGGSFGTAI ASIAADNGAR VNQWLRDPAL IEQINREHRN ARYLPDYAIN
PAVVASGDMQ EVLRDAELVF IAIPSSAFLT VVRQALPWLK PTQILVSTTK GIQEDGFKLM
SQILEEETGF PHIGVLSGPN LASEIAQKHL TATVIASDDP LTRARVQSAL GCDYFRVYAS
NDRYGVELGG ALKNIYAIAA GMAAALGMGE NTRSMLMTRA LAEMSRFAVA LGANPLTFIG
LAGVGDLIVT CSSKLSRNYR VGFALGEDKT LEEAVTALGQ VAEGVNTVSL VREKARREHI
YMPLAEGLYQ VLFNGVPARQ MAQMLMQQEQ SSDVEFILSR QDVFEARRLE PGAEET
//
