ID Q1RL50_CIOIN Unreviewed; 990 AA.
AC Q1RL50; A0A1W2VPK9; F7A8A6;
DT 16-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=Zinc finger protein {ECO:0000313|EMBL:FAA00215.1};
GN Name=Ci-ArfGAP-11 {ECO:0000313|EMBL:FAA00215.1};
GN Synonyms=ci-arfgap-11 {ECO:0000313|Ensembl:ENSCINP00000013767.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|EMBL:FAA00215.1};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|EMBL:FAA00215.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16519883; DOI=10.1016/j.ydbio.2006.01.024;
RA Miwata K., Chiba T., Horii R., Yamada L., Kubo A., Miyamura D., Satoh N.,
RA Satou Y.;
RT "Systematic analysis of embryonic expression profiles of zinc finger genes
RT in Ciona intestinalis.";
RL Dev. Biol. 292:546-554(2006).
RN [3] {ECO:0000313|Ensembl:ENSCINP00000013767.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EAAA01001581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BR000184; FAA00215.1; -; mRNA.
DR RefSeq; NP_001041455.1; NM_001047990.1.
DR STRING; 7719.ENSCINP00000013767; -.
DR Ensembl; ENSCINT00000013767.3; ENSCINP00000013767.3; ENSCING00000006711.3.
DR GeneID; 723804; -.
DR KEGG; cin:723804; -.
DR CTD; 723804; -.
DR GeneTree; ENSGT00940000171062; -.
DR HOGENOM; CLU_006942_0_0_1; -.
DR OMA; MKMECHI; -.
DR OrthoDB; 1449795at2759; -.
DR TreeFam; TF325156; -.
DR Proteomes; UP000008144; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08834; ArfGap_ASAP; 1.
DR CDD; cd07604; BAR_ASAPs; 1.
DR CDD; cd13251; PH_ASAP; 1.
DR CDD; cd11821; SH3_ASAP; 1.
DR Gene3D; 1.25.40.950; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR035836; ASAP1-like_SH3.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45854:SF3; ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 308..400
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 428..549
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 628..660
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 925..987
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 726..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..753
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..775
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..831
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 990 AA; 109850 MW; FA2685B49FCB8E49 CRC64;
MSDRISVIEF LAETKDDVNS PTTSTFTSKM SLCRATIAAL EEASPIFLSA XKKMKNSTKA
MYNSGLAQVS NEANFIENLE KLGAGALYNA KEPEPDIGSA FLKLAVFTKE LSSLFKNLVS
NISNIIMFPL ESLLKGDLKG IKGDMKRPFD KSWKDYDTKV KQVEREKRQL AKDAGMIRNE
ITGAEIAEEM EKERRMFQLQ MCDYLIKANE IKTKKGVDLL QHLVEFYHAQ NTFFTDGYKV
IEHFRAYAED LTSNLHSLRQ AQDEERRQLV ELKTILKTSV SDPDNAPGGK SQANVYNLHQ
LQGNKELGTE KAGYLMKRSE GLRKAWQKRK CIVAGGFLTI SHNNMNKAPV KLNLLTSQLK
LVSEDKKQFD LVAHNRTYRF MAEDDNDAVA WVSVITNSKE DALNRVFGDA AAGKDGNEQN
PGLRELTQSV IDEVRRLPGN DRCCDCNAPE PTWLSTNLGV LLCIECSGIH RDMGVHVSRI
QSITLDDLGT SELLLARSVG NDNFNDIMED KLESEMKPTP SSNMEERKSF IRGKYISRKY
VVHTCADDPD ALTDELGQAI RSCDVFSLLQ LWAEGADMCA PLPGYDDAET ALHVAVSMPN
HDCSGTVLPL VDFLAQNIGS GMNKKTISGN TALHICAEMN QTECMKLLLR SKASPDIENA
RGETALQITR RMDHPGCEEI LEQAASGKFR SIVHINIDWN LTFNDEDDFI SDDDLDDKAL
LSLPQQFIGM SPAKTNNNSG DSHRHRPTSF KERTRPLPDV PPPPPRGPPP AVPQHASAAV
PRARSHTAAP GSIDPRKSGI EGRPPAPAIP NKPDLPLKST PRSSSLVTAN IYPLQVPTND
IRRESTPEIP LKSVTSLRNT RFASFGGKRR KSKQISGLKP GQPGSIEKSR SLPRNSSPSD
LRPDPNRSDA PVPLPRSSQI PPPTPRPKRV RAIYDCEADN QDELTFVENE IIVVTGVEDQ
DWWVGHVEHQ PHRVGVFPVS FVHILSDGAP
//
