ID   Q208S4_9TREM            Unreviewed;       408 AA.
AC   Q208S4;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Legumain {ECO:0000313|EMBL:ABD64147.1};
OS   Opisthorchis viverrini.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX   NCBI_TaxID=6198 {ECO:0000313|EMBL:ABD64147.1};
RN   [1] {ECO:0000313|EMBL:ABD64147.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Laha T., Sripa J., Sripa B., Brindley P.J., Loukas A.;
RT   "Isolation and characterization of specific molecule to Opisthorchis
RT   viverrini infection associated cholangiocarcinoma using immunoscreening of
RT   Opisthorchis viverrini adult worm cDNA library.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C13 family.
CC       {ECO:0000256|ARBA:ARBA00009941}.
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DR   EMBL; DQ402101; ABD64147.1; -; mRNA.
DR   AlphaFoldDB; Q208S4; -.
DR   MEROPS; C13.007; -.
DR   BRENDA; 3.4.22.34; 10800.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd21115; legumain_C; 1.
DR   Gene3D; 1.10.132.130; -; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   InterPro; IPR048501; Legum_prodom.
DR   InterPro; IPR046427; Legumain_prodom_sf.
DR   InterPro; IPR001096; Peptidase_C13.
DR   PANTHER; PTHR12000; HEMOGLOBINASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR12000:SF42; LEGUMAIN; 1.
DR   Pfam; PF01650; Peptidase_C13; 1.
DR   PIRSF; PIRSF019663; Legumain; 2.
DR   PRINTS; PR00776; HEMOGLOBNASE.
PE   2: Evidence at transcript level;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..408
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004199265"
FT   ACT_SITE        154
FT                   /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT   ACT_SITE        195
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
SQ   SEQUENCE   408 AA;  47212 MW;  E58CDFC3BD7E932A CRC64;
     MQRSCLLLTF LLYVNYAAWL GAVCVGSRLF HSDQARNWVV LVAGSNGWEN YRHQADVYHA
     YQIMKRNNIS TEQIITFAYD DIANNPENPF MGKVFNDYTH KDVYEGVHID YRGEDVTPDN
     FLRAMRGDKE LEANGKKVLK SGPEDHVFVY FSDHGADGLL AFPEDDLLAS DLNKTLGYMH
     ENKMYKQMVL YVEACESGSM FQDILPSDIG IYVTTAANSE ESSWATFCRD TIIGTCLADE
     YSYNWLTDSE HHDLSHRTLD DQFQSVKQNT KQSHVSRFGE LPQVLHSHPS RWAHLVTMVR
     RMMKAETEEE HELASRKLYR ALLLAQIVKE TFEEIVTDVT TFHQPTMRML SKSEELQCYE
     EVFQEFKNRC FTIRQVPEVA QYARHLRKLC KEGYETEALV QSVHEVCS
//