UniProt: Q20CL2

Database: UniProt
Entry: Q20CL2_PAPAN

LinkDB:  Q20CL2_PAPAN 
Original site:  Q20CL2_PAPAN

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Ontology (7)   
   GO (6)   
   CAZY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (4)   
   InterPro (2)   
   Pfam (1)   
   PROSITE (1)   
Enzyme (1)   
   BRENDA (1)   
All databases (17)   

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ID   Q20CL2_PAPAN            Unreviewed;       534 AA.
AC   Q20CL2;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE            EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN   Name=UGT1A5B {ECO:0000313|EMBL:ABD75815.1};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|EMBL:ABD75815.1};
RN   [1] {ECO:0000313|EMBL:ABD75815.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Ileum {ECO:0000313|EMBL:ABD75815.1};
RA   Caspersen C.S., Reznik B., Weldy P.L., Abildskov K.M., Stark R.I.,
RA   Garland M.;
RT   "Molecular cloning of baboon UGT1 gene family.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00000301,
CC         ECO:0000256|RuleBase:RU362059};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167, ECO:0000256|RuleBase:RU362059}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167,
CC       ECO:0000256|RuleBase:RU362059}. Microsome membrane
CC       {ECO:0000256|ARBA:ARBA00004111}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004111}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR   EMBL; DQ355196; ABD75815.1; -; mRNA.
DR   RefSeq; NP_001106128.1; NM_001112658.1.
DR   AlphaFoldDB; Q20CL2; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   GeneID; 100126761; -.
DR   KEGG; panu:100126761; -.
DR   CTD; 100126761; -.
DR   OrthoDB; 382054at2759; -.
DR   BRENDA; 2.4.1.17; 4519.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019899; F:enzyme binding; IEA:UniProt.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:UniProt.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:UniProt.
DR   GO; GO:0052695; P:cellular glucuronidation; IEA:UniProt.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR48043:SF157; UDP GLUCURONOSYLTRANSFERASE 1 FAMILY POLYPEPTIDE A3 PRECURSOR-RELATED; 1.
DR   Pfam; PF00201; UDPGT; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU003718};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362059};
KW   Microsome {ECO:0000256|ARBA:ARBA00022848};
KW   Signal {ECO:0000256|RuleBase:RU362059};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362059};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362059}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT   CHAIN           29..534
FT                   /note="UDP-glucuronosyltransferase"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT                   /id="PRO_5005142832"
FT   TRANSMEM        492..515
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
SQ   SEQUENCE   534 AA;  60098 MW;  1B80278CF360A917 CRC64;
     MATGLQVSLP QLATGLLLLL SVQPWAESGK VLVVPTDGSH WLSMQDAVRE LHARGHQVVV
     LSPEVNMHIK EENFFTLTTY AVPWTQDEFD RFLLGHSQSF FETEHLLMRF SRSMAIMNNI
     SLIIHRSCVE LLHNEALIRH LNATSFDVVL TDPFHLCGAV LAKYLSIPTV FFLRNILCDL
     DFKGTQCPNP YSYIPKFLTT NSDHMTFLQR VKNMLYPLAL SYICDTVSVP YASLASELFQ
     REVSVVDLLS HASVWLFRSD FVMDYPRPIM PNMVFIGGIN CANRKPLSQE FEAYINASGE
     HGIVVFSLGS MVAEIPEKKA MAIADALGKI PQTVLWRYTG TPPSNLANNT ILVKWLPQND
     LLGHPMTRAF ITHAGSHGIY EGICNGVPMV MMPLFGDQMD NAKRMETKGA GVTLNVLEMT
     SEDLENALKA VINDKSYKEN IMHLSSLHKD RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH
     DLTWYQYHSL DVIGFLLAIV LTVAFIAFKC CAYGYRKCFG KKGRVKKAHK SKTH
//

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