ID Q20DZ3_9HIV1 Unreviewed; 501 AA.
AC Q20DZ3;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ABD67047.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ABD67047.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ABD67047.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16339909; DOI=10.1073/pnas.0504658102;
RA Frost S.D., Wrin T., Smith D.M., Kosakovsky Pond S.L., Liu Y., Paxinos E.,
RA Chappey C., Galovich J., Beauchaine J., Petropoulos C.J., Little S.J.,
RA Richman D.D.;
RT "Neutralizing antibody responses drive the evolution of human
RT immunodeficiency virus type 1 envelope during recent HIV infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:18514-18519(2005).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; DQ296964; ABD67047.1; -; Genomic_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 2.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Viral envelope protein {ECO:0000313|EMBL:ABD67047.1};
KW Virion {ECO:0000313|EMBL:ABD67047.1}.
FT DOMAIN 1..52
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 47..420
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 440..499
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABD67047.1"
FT NON_TER 501
FT /evidence="ECO:0000313|EMBL:ABD67047.1"
SQ SEQUENCE 501 AA; 55984 MW; D2B9EBD5E5E46AB1 CRC64;
VTENFNVWKN NMVEQMQEDI ISLWDQSLKP CVKLTPLCVT LNCTNVILNE NSTYNYNWTH
KTVTDEMKNC SFNATTSIRD KITKEYALFY RLDIVPIEED NTSYTLINCN TSVITQACPK
TTFEPIPIHY CTPAGFAILK CNDKKFNGSG PCRNVSTVQC THGIKPVVST QLLLNGSLAE
EEVVIRSENF TNNAKTIIVQ LNKSVAINCT RPGNNTRKSI HVGPGRAFYT TGDIIGDIRQ
AHCNLSRVEW NNTLKQIVEK LREQFGNKTI SFNQSSGGDP EIIMHSFNCA GEFFYCNTTQ
LFNSTWQNNS TGNSTGNNTD IITLPCGIKQ IINRWQEVGK AMYAPPIRGN ISCSSIITGL
LLTRDGGANT TNNTEIFRPG GGDMRDNWRS ELYKYKVVKI EPLGIAPTKA KRRVVQREKR
AVGTIGAMFL GFLGTAGSTM GAAAVTLTVQ ARQLLSDIVQ QQNNLLRAIE AQQHMLQLTV
WGIKQLQARV LAVERYLRDQ Q
//
