ID Q20EB3_9HIV1 Unreviewed; 509 AA.
AC Q20EB3;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ABD66927.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ABD66927.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ABD66927.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16339909; DOI=10.1073/pnas.0504658102;
RA Frost S.D., Wrin T., Smith D.M., Kosakovsky Pond S.L., Liu Y., Paxinos E.,
RA Chappey C., Galovich J., Beauchaine J., Petropoulos C.J., Little S.J.,
RA Richman D.D.;
RT "Neutralizing antibody responses drive the evolution of human
RT immunodeficiency virus type 1 envelope during recent HIV infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:18514-18519(2005).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; DQ296844; ABD66927.1; -; Genomic_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ABD66927.1};
KW Virion {ECO:0000313|EMBL:ABD66927.1}.
FT TRANSMEM 425..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..424
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 443..502
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABD66927.1"
FT NON_TER 509
FT /evidence="ECO:0000313|EMBL:ABD66927.1"
SQ SEQUENCE 509 AA; 56708 MW; FD1F383B39A0E7F9 CRC64;
NFNVWKNNMV DQMHEDIISL WDQSLKPCVK LTPLCVTLHC KDYEKKNTTT NSTNTTSSNW
GEMERGEIQN CSFNITTNIK DKVQKEYALF YKLDVVQIDN NTIDNSTRYR LISCNTSVIT
QACPKVSFEP IPIHLCAPAG FAILKCNNKT FNGSGPCTNV STVQCTHGIR PVVSTQLLLN
GSLAEKGIVI RSENISNNAK TIIVQLKEPV KINCTRPNNN TRRSIPIGPG RAFFATGDII
GDIRQAHCNL SRSKWNDTLR QVAAKLKEHF NKTIAFNKSS GGDPEIILHT FNCGGEFFYC
STTELFNSTW NDTSGNDIGT NNRSDIITLP CKIKQIINRW QEVGKAMYAP PIRGNISCSS
NITGILLTRD GGKNNNDTEI FRPGGGDMRD NWRSELYKYK VVKIEPLGVA PTRAKRRVVQ
REKRAVGIGA VFLGFLGTAG SAMGAASLTL TVQARQLLSG IVQQQNNLLR AIEAQQHLLQ
LTVWGIKQLQ ARVLAVERYL KDQQLLGIW
//