ID Q212V6_RHOPB Unreviewed; 2257 AA.
AC Q212V6;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:ABD88580.1};
GN OrderedLocusNames=RPC_3035 {ECO:0000313|EMBL:ABD88580.1};
OS Rhodopseudomonas palustris (strain BisB18).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Rhodopseudomonas.
OX NCBI_TaxID=316056 {ECO:0000313|EMBL:ABD88580.1};
RN [1] {ECO:0000313|EMBL:ABD88580.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BisB18 {ECO:0000313|EMBL:ABD88580.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Pelletier D.A., Kyrpides N., Anderson I., Oda Y., Harwood C.S.,
RA Richardson P.;
RT "Complete sequence of Rhodopseudomonas palustris BisB18.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000301; ABD88580.1; -; Genomic_DNA.
DR STRING; 316056.RPC_3035; -.
DR KEGG; rpc:RPC_3035; -.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_230576_0_0_5; -.
DR OrthoDB; 9778690at2; -.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05274; KR_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 1.10.1240.100; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 14..438
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1590..1664
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1669..1747
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2257 AA; 244317 MW; 06D0DA4C579FAABE CRC64;
MKDDVSYREV YADTQPIAII GAGCRFAGAR NPFSFWRRIV DGEEFTRRVT EEDLRQAGFD
PGLLDHPGFV PIASVVEDVE HFDAEWFGYS PAEAATIDPQ QRVFLTCAWE ALDMAGLASA
ARGSRVGVFG SARMSTYRLP KAGDVLEIMT PRVFQRLIGN DKDYLASRVA YKLGLSGPAV
TIQSACSSSL VAIHTACEQL RSGECDLALA GGAALTFPMA AGYMHHSGMI FSPDGHCRPF
DADAGGTFMG NGVGVLLLKP LLRALEDGDA VIAVIRGSAV NNDGDGKAGY TAPSLRGQQS
VIEEAMALAG VTAQEVGLVE AHGTATPLGD PLEVEALARA FDAGSSASRS CALGSIKANT
GHLDTAAGVA SLLKAAFAVR YGLIPPCLHF QTPNPALRID ETPFYVPQAL IPWEAERRIA
GVSSFGIGGT NCHVVVERLP PGLQPASRQE GLTAILVVSG RDEETLRQTA AMHADTLLDH
PPEEGLLNYC ATVAHHRTMM PYRLAVAGDS VTALVGRLHE VSRHGSLASE LMTGGHNGCV
VWAAKGTEEL GGRLGDTIPK LDDVIPRPRH RALAPSATLL GERHVEEDGE DSRRSGGAAD
VWRTAVDSLA AAAVRTTDDH DWSSLSEEAA TVRELHAVHA GQAVVDLALF PDAKTYLTID
EVLQRGRVKP VYRQLLQRLL RDLSDEGVLA RDGERYGRLR LRAAGATDGL LAKMRVHGYG
RLADLVMRAG GHLAAMLRGE VDPVSVVFPS GAMDDVEEMY ERQRDSVYLN GIAAEAVAAV
VAAMPRDAEI RVLEIGAGTG GTTGALLPTL PRSRCDYLFT DIGPLFLRRA EKKFAAYPFI
RYGTFDFERS HTEQGLAEAQ FHLIVAANVI HNARDLRASL GRARRLLAPG GILLLREITE
PKPLFDFVFG PLTPEVSDIE ERGGEFFPAI DRWTEALSDA GFVGWTSAPG VEQITARIGE
RIILARNSGD LKFATRRAPA CGTTAPMDVA GLLQRLVERH GCCHWRLEDV SCAPATGAEN
EQWRDSGQEL ALLGGASGRV LLSGRRGTKT VAMLPRLDRT RARRLDGEPR RVLSEMLGVL
GPNCAFHASS IECTSVPKEG AHWLMQHKSD AGVDLTLFDD AGWPLIRLEQ AHPVSEADAA
SPSLYRWTWR AEDGESAWQE ISWDAERIVL LSEDGSNLSE LLGVAPVRDF ASVPSNAPAG
AHIVVDLTGG STRPIAQLYA DVAAILDIAA RTHGRVTVMT SGAAAVAAWD AVRHPEMAGI
PALLRVAGRE RRDLVLRWID VDEPADRDGR WKRWFGGDAA EDAIAVRHGQ IFVPRLTRLA
TARSLATINQ DGIYLITGGL SPLALSTADW LVAQGCREIW LVARRRPAAN EADRVEALRA
AGANVRLSCD VDVADLTALE TLLKSIQQDA LPLAGIFHLA GVLQDGSIAT LGPSHFAQAI
APKWVGACTL LSWMPRLKPD FLLLYSSAAT IFGPPGQAAH AVANAMLEGL ARQASARGLP
VKALSWGFWE EERSDRAELT KSLHGQGMLG LAPNEAFRLI HAALADAAAV VAPMHIDWER
IADQLGESSP RILEDCVRPT GSAPLRPASR NVRSKLREIV ALLLKAEPMT LDVDANLVQL
GLDSLMFLEL SHTLKVEFGV DVSAEVAIEC NTLSKLSDCL QSQLAETAVS DVDEVQAILR
RELAVLLRRP EDQLDPTCNL VQSGLDSLMF LEFSQRVSKT LGVTVSAETA LQYDTLAKLA
AAVVEQRSGR RKTASPVRAA LDELAAAEPH LLLTNGDLCP SSAPASAHAS LSPLQRAWWL
GRRDGRILGG IARHLYVEYD KTPTVFDIDA FEVAWNSLIV RHAGLRTTID ADGNARVFEE
TRAYAIVRED LRGLDVLQRD LRLADIRERM SGQRLDLSAW PHFELRASLL DDSRLRLHLD
IDTTCVDIES FQVILHELGA LIREPERQLP SLSFSPSDYR RGMELIGTTS VHADNEADAL
RRAARLAGAP DLPLALNPAE LTTIRFQIRR ESLTRVDWLA LKGEARHRGI SPTALLLSIY
AAALSAWCGD CSRFALQLAY SDRRSLHAQV MNIVCDASAI LPIDFDLREN ASFAEMARTT
QAKIDAHLAH ETYDGVSMLA ETNHGRRFPD TPSLGLPIVF TSLFGVRSAY ALPETADPVL
GMPNYEYAAQ PQVALNFQAL EEEHSMLFNL DWVDGLFPDL MGEALILALS SLLQSLAANP
GTFDLPLSKL ASADPEIGVV RTQAPFSLAA WLQRDVR
//
