ID Q21703_CAEEL Unreviewed; 347 AA.
AC Q21703;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 169.
DE RecName: Full=Sorbitol dehydrogenase {ECO:0000256|ARBA:ARBA00026132};
DE AltName: Full=Polyol dehydrogenase {ECO:0000256|ARBA:ARBA00032485};
GN ORFNames=CELE_R04B5.6 {ECO:0000313|EMBL:CAA94842.1}, R04B5.6
GN {ECO:0000313|EMBL:CAA94842.1, ECO:0000313|WormBase:R04B5.6};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA94842.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA94842.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA94842.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284605; CAA94842.1; -; Genomic_DNA.
DR PIR; T23890; T23890.
DR RefSeq; NP_505590.1; NM_073189.3.
DR AlphaFoldDB; Q21703; -.
DR SMR; Q21703; -.
DR IntAct; Q21703; 1.
DR STRING; 6239.R04B5.6.1; -.
DR EPD; Q21703; -.
DR PaxDb; 6239-R04B5-6; -.
DR PeptideAtlas; Q21703; -.
DR EnsemblMetazoa; R04B5.6.1; R04B5.6.1; WBGene00011004.
DR GeneID; 179404; -.
DR KEGG; cel:CELE_R04B5.6; -.
DR UCSC; R04B5.6; c. elegans.
DR AGR; WB:WBGene00011004; -.
DR WormBase; R04B5.6; CE06216; WBGene00011004; -.
DR eggNOG; KOG0024; Eukaryota.
DR GeneTree; ENSGT00550000074781; -.
DR HOGENOM; CLU_026673_11_5_1; -.
DR InParanoid; Q21703; -.
DR OMA; MRVAMYY; -.
DR OrthoDB; 3017546at2759; -.
DR PhylomeDB; Q21703; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00011004; Expressed in larva and 3 other cell types or tissues.
DR GO; GO:0003939; F:L-iditol 2-dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006062; P:sorbitol catabolic process; IBA:GO_Central.
DR CDD; cd05285; sorbitol_DH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR045306; SDH-like.
DR PANTHER; PTHR43161; SORBITOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43161:SF9; SORBITOL DEHYDROGENASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Proteomics identification {ECO:0007829|EPD:Q21703,
KW ECO:0007829|PeptideAtlas:Q21703};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 12..345
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 347 AA; 37294 MW; 6B8B1DE1B2518AD2 CRC64;
MSQDNLSAVL YGINDLRLEQ APISKPGPRQ VLVKINTVGI CGSDVHFLTH GAIGSFVVKE
PMVLGHESSG VVSEIGSEVK GFKVGDRIAM EPGLPCKLCE HCKIGRYNLC PDMRFFATPP
VNGALSRFVV HDADFCFKLP DNLSFEDGAL LEPLSVAIQA CRRGTVQMGQ KILVLGAGPI
GVLNLLTAKA IGASKVVITD LNDERLALAR LLGADATINV MGKRSDEVRS EIIKAFGDQQ
PHVSIECTGV QPCVETAIMT TRSGGVVVLV GLGAERVEIP LIQSPTREVD LRGTFRSANC
YSTAIELISS GKLDLSGLTR AHYKLEESLE AFKRTQNGDV IKVFIHC
//
