ID Q22770_CAEEL Unreviewed; 527 AA.
AC Q22770;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 2.
DT 27-MAR-2024, entry version 148.
DE SubName: Full=Glucuronosyltransferase {ECO:0000313|EMBL:CAA94378.2};
GN Name=ugt-54 {ECO:0000313|EMBL:CAA94378.2,
GN ECO:0000313|WormBase:T25B9.7};
GN ORFNames=CELE_T25B9.7 {ECO:0000313|EMBL:CAA94378.2}, T25B9.7
GN {ECO:0000313|WormBase:T25B9.7};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA94378.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA94378.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA94378.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000301};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; BX284604; CAA94378.2; -; Genomic_DNA.
DR PIR; T25263; T25263.
DR RefSeq; NP_501996.2; NM_069595.5.
DR AlphaFoldDB; Q22770; -.
DR SMR; Q22770; -.
DR STRING; 6239.T25B9.7.2; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR EPD; Q22770; -.
DR PaxDb; 6239-T25B9-7-2; -.
DR PeptideAtlas; Q22770; -.
DR EnsemblMetazoa; T25B9.7.1; T25B9.7.1; WBGene00012013.
DR GeneID; 188885; -.
DR KEGG; cel:CELE_T25B9.7; -.
DR UCSC; T25B9.7; c. elegans.
DR AGR; WB:WBGene00012013; -.
DR WormBase; T25B9.7; CE32939; WBGene00012013; ugt-54.
DR eggNOG; KOG1192; Eukaryota.
DR HOGENOM; CLU_012949_1_3_1; -.
DR InParanoid; Q22770; -.
DR OMA; PFWYYSV; -.
DR OrthoDB; 2880257at2759; -.
DR PhylomeDB; Q22770; -.
DR Reactome; R-CEL-9753281; Paracetamol ADME.
DR Reactome; R-CEL-9757110; Prednisone ADME.
DR Reactome; R-CEL-9840309; Glycosphingolipid biosynthesis.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00012013; Expressed in larva and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF154; GLUCURONOSYLTRANSFERASE; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 1: Evidence at protein level;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:Q22770,
KW ECO:0007829|PeptideAtlas:Q22770};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 479..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 527 AA; 59463 MW; 2F40B9D812392F26 CRC64;
MKTLLGFLIL PGFANCLNIL FYVSVIAQSH IPFHNTAIKV LLDRGHTVDL VIAQLNEMVK
LKFPNGVGKN YTFGYEDPNF YRKNAGHLSD IFVEKPIPMA EFLTFDDMTF NLCETVVKDP
NLLNYIKQGN YDIGLSSDYD PCANILMHAG GVPSKASMVP TPLFQPQIVS AGLPSPASVY
GTVLYPKGDD SFFNRLFHLI RHTYNIYFVA PRLMEKYNNL LLETFGPTFP SAEEIERNVD
IILVNSNEII EKPRPVSHKI KYIGGMGKKK AQPLNKEFND ILATSNKGVV LFSFGTQVAT
SKVPIEIRKN FVTAFKHFPD FSFLWKYDNL TDDAELFADS SNIHRVEWLP QTDLLGDNRV
KAFISHMGLN SFLETSAAGI PVLAVPLFID QQHNALNAVS RDIGVIVERH QLTVENLVNA
LQKLLYNPKY GENAKMISKM MNEKPEQSER LFVDWVEYAA KNPGLHKIMN LPGAELTPFW
YYSVDVILIV VLSLTSSLII IWKTLSFIKC QISIRSVRSI EPKSKSE
//
