GenomeNet

Database: UniProt
Entry: Q22940_CAEEL
LinkDB: Q22940_CAEEL
Original site: Q22940_CAEEL 
ID   Q22940_CAEEL            Unreviewed;       523 AA.
AC   Q22940;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2004, sequence version 4.
DT   24-JAN-2024, entry version 164.
DE   SubName: Full=Potassium channel domain-containing protein {ECO:0000313|EMBL:CCD65414.1};
GN   Name=twk-28 {ECO:0000313|EMBL:CCD65414.1,
GN   ECO:0000313|WormBase:C52B9.6};
GN   ORFNames=C52B9.6 {ECO:0000313|WormBase:C52B9.6}, CELE_C52B9.6
GN   {ECO:0000313|EMBL:CCD65414.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD65414.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD65414.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD65414.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC       1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC       ECO:0000256|RuleBase:RU003857}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX284606; CCD65414.1; -; Genomic_DNA.
DR   RefSeq; NP_508732.3; NM_076331.3.
DR   AlphaFoldDB; Q22940; -.
DR   SMR; Q22940; -.
DR   STRING; 6239.C52B9.6.1; -.
DR   PaxDb; 6239-C52B9-6; -.
DR   EnsemblMetazoa; C52B9.6.1; C52B9.6.1; WBGene00006680.
DR   GeneID; 183714; -.
DR   UCSC; C52B9.6; c. elegans.
DR   AGR; WB:WBGene00006680; -.
DR   WormBase; C52B9.6; CE35710; WBGene00006680; twk-28.
DR   eggNOG; KOG1418; Eukaryota.
DR   HOGENOM; CLU_495428_0_0_1; -.
DR   InParanoid; Q22940; -.
DR   OMA; EIPMEMD; -.
DR   OrthoDB; 38977at2759; -.
DR   PhylomeDB; Q22940; -.
DR   Reactome; R-CEL-1299503; TWIK related potassium channel (TREK).
DR   Reactome; R-CEL-5576886; Phase 4 - resting membrane potential.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00006680; Expressed in material anatomical entity and 3 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR   PANTHER; PTHR11003:SF98; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PRINTS; PR01333; 2POREKCHANEL.
DR   PRINTS; PR01095; TASKCHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003857, ECO:0000313|EMBL:CCD65414.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003857};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003857};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT   TRANSMEM        59..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        288..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        319..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        342..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          165..221
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
FT   DOMAIN          295..365
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
FT   REGION          242..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..266
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   523 AA;  59215 MW;  9652744BAB2D0FE7 CRC64;
     MYTHNAVDTF DMGSADSSLS SLNEIPMEMD LTSAGPPISD DETEVETKEK KLFVYAKRIL
     PHVGLVILLF LYLIAGAFLF RYLEAPKELE TRNHELTTIL GLRDEFQDHI WNITQDSDNR
     ISREAFNAIN QEYFEQLVKN MFQAYRNQFI TAKHLLNKTR EDEVLWTFPN SMFFAATVIT
     TIGYGNLVPI TVTGRVACII FALLGIPLLL VTIADIGKFL SEFLSYLYRS YRGFKRKLRR
     QSKKITSQYR SQSQSRSSSV MGSSKAGSMN LHDIDSDSED SAGDELRIPV FMVLLVLLAY
     TAIGGFLFQS WEHLEYFEAF YFCFITMATV GFGDIVPNEQ VYVFFTMAYI IFGLSLATMC
     IDLAGTEYIR KIHYLGTKME DAKGAVMTGL QAGEHLLKHT GIEVIKTAGG KLVQVRGAVL
     SSKEARELGM SYLLQFNYQH KNVLYEPLTG NLAKVVKEAN IKILPDDITE KDGYIVQNKS
     YDRPVLGERG FVRLNGNAIK RIMIPLRNQA ICVPYLIQKE SDV
//
DBGET integrated database retrieval system