ID Q22940_CAEEL Unreviewed; 523 AA.
AC Q22940;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2004, sequence version 4.
DT 24-JAN-2024, entry version 164.
DE SubName: Full=Potassium channel domain-containing protein {ECO:0000313|EMBL:CCD65414.1};
GN Name=twk-28 {ECO:0000313|EMBL:CCD65414.1,
GN ECO:0000313|WormBase:C52B9.6};
GN ORFNames=C52B9.6 {ECO:0000313|WormBase:C52B9.6}, CELE_C52B9.6
GN {ECO:0000313|EMBL:CCD65414.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD65414.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD65414.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD65414.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR EMBL; BX284606; CCD65414.1; -; Genomic_DNA.
DR RefSeq; NP_508732.3; NM_076331.3.
DR AlphaFoldDB; Q22940; -.
DR SMR; Q22940; -.
DR STRING; 6239.C52B9.6.1; -.
DR PaxDb; 6239-C52B9-6; -.
DR EnsemblMetazoa; C52B9.6.1; C52B9.6.1; WBGene00006680.
DR GeneID; 183714; -.
DR UCSC; C52B9.6; c. elegans.
DR AGR; WB:WBGene00006680; -.
DR WormBase; C52B9.6; CE35710; WBGene00006680; twk-28.
DR eggNOG; KOG1418; Eukaryota.
DR HOGENOM; CLU_495428_0_0_1; -.
DR InParanoid; Q22940; -.
DR OMA; EIPMEMD; -.
DR OrthoDB; 38977at2759; -.
DR PhylomeDB; Q22940; -.
DR Reactome; R-CEL-1299503; TWIK related potassium channel (TREK).
DR Reactome; R-CEL-5576886; Phase 4 - resting membrane potential.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00006680; Expressed in material anatomical entity and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF98; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01095; TASKCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857, ECO:0000313|EMBL:CCD65414.1};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 59..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 165..221
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 295..365
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 242..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 523 AA; 59215 MW; 9652744BAB2D0FE7 CRC64;
MYTHNAVDTF DMGSADSSLS SLNEIPMEMD LTSAGPPISD DETEVETKEK KLFVYAKRIL
PHVGLVILLF LYLIAGAFLF RYLEAPKELE TRNHELTTIL GLRDEFQDHI WNITQDSDNR
ISREAFNAIN QEYFEQLVKN MFQAYRNQFI TAKHLLNKTR EDEVLWTFPN SMFFAATVIT
TIGYGNLVPI TVTGRVACII FALLGIPLLL VTIADIGKFL SEFLSYLYRS YRGFKRKLRR
QSKKITSQYR SQSQSRSSSV MGSSKAGSMN LHDIDSDSED SAGDELRIPV FMVLLVLLAY
TAIGGFLFQS WEHLEYFEAF YFCFITMATV GFGDIVPNEQ VYVFFTMAYI IFGLSLATMC
IDLAGTEYIR KIHYLGTKME DAKGAVMTGL QAGEHLLKHT GIEVIKTAGG KLVQVRGAVL
SSKEARELGM SYLLQFNYQH KNVLYEPLTG NLAKVVKEAN IKILPDDITE KDGYIVQNKS
YDRPVLGERG FVRLNGNAIK RIMIPLRNQA ICVPYLIQKE SDV
//