ID Q22976_CAEEL Unreviewed; 627 AA.
AC Q22976;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 2.
DT 27-MAR-2024, entry version 133.
DE SubName: Full=Otopetrin-2 {ECO:0000313|EMBL:CCD70029.1};
GN Name=otpl-7 {ECO:0000313|EMBL:CCD70029.1,
GN ECO:0000313|WormBase:F45F2.7};
GN ORFNames=CELE_F45F2.7 {ECO:0000313|EMBL:CCD70029.1}, F45F2.7
GN {ECO:0000313|WormBase:F45F2.7};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD70029.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD70029.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD70029.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the otopetrin family.
CC {ECO:0000256|ARBA:ARBA00006513}.
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DR EMBL; BX284605; CCD70029.1; -; Genomic_DNA.
DR RefSeq; NP_505194.2; NM_072793.2.
DR AlphaFoldDB; Q22976; -.
DR STRING; 6239.F45F2.7.1; -.
DR PaxDb; 6239-F45F2-7; -.
DR EnsemblMetazoa; F45F2.7.1; F45F2.7.1; WBGene00018480.
DR GeneID; 185808; -.
DR KEGG; cel:CELE_F45F2.7; -.
DR UCSC; F45F2.7; c. elegans.
DR AGR; WB:WBGene00018480; -.
DR WormBase; F45F2.7; CE45354; WBGene00018480; otpl-7.
DR eggNOG; KOG4740; Eukaryota.
DR GeneTree; ENSGT00970000196165; -.
DR HOGENOM; CLU_011508_3_1_1; -.
DR InParanoid; Q22976; -.
DR OMA; FVYHTFE; -.
DR OrthoDB; 2877304at2759; -.
DR PhylomeDB; Q22976; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00018480; Expressed in adult organism and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015252; F:proton channel activity; IBA:GO_Central.
DR GO; GO:1902600; P:proton transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004878; Otopetrin.
DR PANTHER; PTHR21522:SF29; OTOPETRIN-LIKE; 1.
DR PANTHER; PTHR21522; PROTON CHANNEL OTOP; 1.
DR Pfam; PF03189; Otopetrin; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 65..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 540..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 627 AA; 70855 MW; 75AE6B2C4446A22C CRC64;
MVVRTTSKNE LARKEPLREK ESIVSVASTS TAPLDHVTVP NALPSPTESL LEHPQWIRNP
KALRFLVGLL TSMYVLLLTI VSCLISISSA WSSPDLWLAE TIFSLLMYLI AILFFMYTYL
MIIYPKPINM LIMILNRKTS LVPRPDRWLL SDPIHNGEGA GTLYLRLGAI FFGTLGSVLW
GCEIFLCFSG ECVHRLVVAK HIAAIIFTFL QMHFIVCNSK ITFHRSNILA SFGMMHCVAV
NLWTWFSMCL VKAQVKKLKK QKKELEYHSS SSSSSDSSSS SEEILEPESS TLLENLIEVV
LEKLKPGKGT TYTSTPYPYT NSSNTTSLLR MQSMVRLGDF SSFLLTCLVE YSLIGAAICF
IIWKYMGATN IEMKVDKKKK KLRMDCHNTT IGLFLGIFFM TAAFVTIGIY TMLYNKKKTQ
SADLVIGIVN LILFCVTLLA TIFGAWRMRV LQYRLHAHGE VIDEILLIIG LVGELIYCSI
GFDMIVNGNR TGSHVPNLPI AVFTFRIIQV IIQAMYILIA SRLRCLSEVN ARTQPGKQTL
TFLVLINITL FVYHTFEGMK STYGFPALME TKYFELLNIS SPLVVFYRFH SSACLAEIWK
HAYSTKHHHH SHQTPINSPT SESQHHV
//
