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Database: UniProt
Entry: Q229U3_TETTS
LinkDB: Q229U3_TETTS
Original site: Q229U3_TETTS 
ID   Q229U3_TETTS            Unreviewed;      1570 AA.
AC   Q229U3;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   25-OCT-2017, entry version 61.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR82058.2};
GN   ORFNames=TTHERM_01337370 {ECO:0000313|EMBL:EAR82058.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR82058.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662395; EAR82058.2; -; Genomic_DNA.
DR   RefSeq; XP_001029721.2; XM_001029721.3.
DR   STRING; 5911.EAR82058; -.
DR   EnsemblProtists; EAR82058; EAR82058; TTHERM_01337370.
DR   GeneID; 7837561; -.
DR   KEGG; tet:TTHERM_01337370; -.
DR   InParanoid; Q229U3; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    456    473       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    493    515       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    536    555       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    591    613       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    634    656       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    668    688       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      775    886       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED     1137   1164       {ECO:0000256|SAM:Coils}.
FT   COILED     1473   1507       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1570 AA;  183995 MW;  51297122847E0106 CRC64;
     MEQQQVKPLQ YIQNVDNNSA SETLRNLDEN SMRDGAIIRG EMFSDTYRRS ILSELMILKN
     KQDDEDYKPD YSESCELGYI DNNRQKCQVS ESNSSKQQQS QNDDKKTGNN YKQSPNILQF
     EESSFLERDN SLSSYESSSS SNSENEGANP QNNEGTHQQI QDESMYDRTN VQNYSRYQYS
     FYNRKSNNPV HNQINLVNDN KQGQQKLDSL LFLQQNQSNL VNGQVSEQNH QSDLDFKAGQ
     ANSQQNQNMI LSGQSKKIAN NQNIQDSSSQ HLKFGINQGH NTSYDYGSQM QKSQELTVGL
     AQLKQQSLNL LLKDPSQKNT NKYSIQKYQE NKRISYNTGS RKKKHHVKNY LSLMCYVKRF
     TNILKTVSTA YKFRSMSKKN FEIIGDLSSN YRFYKLSQYL QQDEPVWYEK FWYTLKKLCR
     TLIWNPINEW NCTKFLIESF QNRIQVIQPE STFKQYWDFF SNIFFIVNIF YIPVRVSFDF
     TNVAYPSIPI TFILYYLPPI LLIIEMILKL NTAIYKQGMT TSNRSQIFYH YMKSEFMIDF
     IICFTQILSI ILNIIELKSF IIFRYRQVSK VLNQMEERLN LNEQQSAYLN LFRLVFMIVF
     IAHICGCSFY LVTKIERFYG LTGLWTERME ITSYTIVQQY ITSLYWAVIT MITLGYGDIT
     PQNTTERAFV ILITMVSCGT FAYSINAIGQ IVQQIGKKEN EERKQINMLM SLMKNRGLTN
     LQLLMKIRRN FQYLLEQDSE NNQEGVKFLQ QIDPNLKNEV MRDIYGKILS KKKIFHLNFS
     KNVIDSLCLK LREQTFGPED VIIKENELVK SIYFVMSGEA QGYINVSSKF QKSETTSFTD
     NTISVLSKFQ KGDIFGEKAF FRNQLSEYGV KARTIVTVAY LRMDDFVECL KEKEEDFEKF
     CLLRDNLQIY NISKGLEIKC FGCSQFTHTI VNCPHSKYNP DYDKILYLNN REVFQERQQY
     KRSKQRSGNT ISIADEIYSQ GVKFMMDYFS IETLQNYFEE KELAQVQHLG TLNKQQYNEA
     MLLQQNQMNI QLDNFGYISG SNPNYSPGIK AQQLKILQQQ MNSKDSEYII SPEQIISQQN
     FLLNAKNQQS NEQRSRDLSV IQDEPEKSQF VSDLEDFNRE RGASSSIQKF SSSRFQNELI
     KYELQQQQQQ QQQQQQQFAQ QQQVVQFAKQ IKPISLKRID SNDQTEQPNN YYGYYDQNIL
     NYLTPKNSNK STGNAYGQMK GQPNSLLSQF ALNQDSNPSN FRSSISNTPS NNPNIMKTAI
     HRDSILMDKE KMSYLQPRQI RNITIEQKDD SDNDEGENKN LKKRMSQSAV SNNANVSPDL
     TSLDNQRSSR HRDSSSQWNT KKSAVNFQTI NQNWLDKNQF FTINNFDLAK QFKIYFTHNN
     QTKVIQHYTQ RVMKKLQKQN QQSINNKEDI QKIIKSYQST LLKSPKKRNQ TLMDKKSIFT
     IYKSEGLLKK KDTDLEYSQN KNLDQSFKQN SSINHANNLL ESQAINMDKS EQKHNNRNKK
     INLLENNGYL VNQQKLVIKE LNLKTHQIFQ LTNEIVNKSF QIFSQQNIQS ITRLQDKNND
     IQNYQINNLN
//
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