ID Q22AQ5_TETTS Unreviewed; 421 AA.
AC Q22AQ5;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=RING-H2 zinc finger protein {ECO:0000313|EMBL:EAR82380.1};
GN ORFNames=TTHERM_01169480 {ECO:0000313|EMBL:EAR82380.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR82380.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662687; EAR82380.1; -; Genomic_DNA.
DR RefSeq; XP_001030043.1; XM_001030043.1.
DR AlphaFoldDB; Q22AQ5; -.
DR STRING; 312017.Q22AQ5; -.
DR EnsemblProtists; EAR82380; EAR82380; TTHERM_01169480.
DR GeneID; 7822865; -.
DR KEGG; tet:TTHERM_01169480; -.
DR eggNOG; KOG0800; Eukaryota.
DR HOGENOM; CLU_652989_0_0_1; -.
DR InParanoid; Q22AQ5; -.
DR OMA; SIHEECA; -.
DR OrthoDB; 140984at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45931; SI:CH211-59O9.10; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT TRANSMEM 124..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 373..416
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 49075 MW; BBDCC4CAB518D329 CRC64;
MSHKFSRFQD EEDADFESGQ ELDDSQTKQI KLSDETTNDL DSSDYQFRFD NEKEKAQIQN
FQEKQTSGNE DQNSSEGQQS DRESDGLEST SNGSNAKTKQ NKDLTVSKLL VVALSKLELP
IKYLLAYQIS LLMLKISRVI LVLGLLFKLL FEMSCQKSSI HTLLIFAFLR DVISGILDLQ
FIFKIYEIRY KINKQHYDDQ VKSVGKDIIK SKREALQSSQ QFFGRFTQIE AITQIQQAPS
YEMFELETAI GNLMPYVAYF MKILKYSYYF LFLISVIFII RYDDEQFCHV FEKYTIIYLF
LPIYFLFLVI FLCLTFLGFF LTIILALLLI FLGKYVHGKY KQQKQQQINE FRAKNLSSVS
YSSIQNQISN NQCAVCLNNY QENDKITVLK CSPQHHFHHS CLQKWVALKG QCPSCRSNQI
V
//
