ID Q22DA4_TETTS Unreviewed; 3633 AA.
AC Q22DA4;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 22-FEB-2023, entry version 77.
DE SubName: Full=MIR domain protein {ECO:0000313|EMBL:EAR83298.2};
GN ORFNames=TTHERM_00992990 {ECO:0000313|EMBL:EAR83298.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR83298.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662439; EAR83298.2; -; Genomic_DNA.
DR RefSeq; XP_001030961.2; XM_001030961.2.
DR EnsemblProtists; EAR83298; EAR83298; TTHERM_00992990.
DR GeneID; 7825010; -.
DR KEGG; tet:TTHERM_00992990; -.
DR eggNOG; KOG3533; Eukaryota.
DR HOGENOM; CLU_224673_0_0_1; -.
DR InParanoid; Q22DA4; -.
DR OrthoDB; 4241306at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006816; P:calcium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR13715:SF99; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3153..3172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3235..3258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3278..3301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3359..3384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2629..2739
FT /note="RyR/IP3R Homology associated"
FT /evidence="ECO:0000259|Pfam:PF08454"
FT REGION 1525..1545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2148..2170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3549..3571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3591..3613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 812..839
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3470..3504
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3633 AA; 428785 MW; E916EFC46F6CEC05 CRC64;
MQQNRDPQIN QNDPFLNQQL QEGVLQLQTL QQQPIYFGDL ICIKVEGIGS KKYMHSEGFY
PSCIKCIDYE DTGDNLTDID GSIFEICNPI QYFSKQNRYQ DNQSDLSDKN QNFNKNKTLV
NTQSITSPSL FNQKNNYDTQ DSLNKNLQAQ QFESYSQNRV GADSYMQYDS NQSKDGVLKM
NQQNMQSDEY FQLKAKTNKN RGSDEQTYLN SGEEHYENQV TLGFNQNFIL RHKRSNKFLY
LVEEDLEYYS LILSSKPSLF KISPSFKSQV VQTKTVYYNS FIYIQAVPFA TASNKDIYLV
IDEAMQYVNS SNYIAPGGGS FVSPKFTNYT CFFGDFFFSP NQKTCLHIEP YRQNLSYFQK
IKGTQKGISN MNNENEQLFL RYGDVVKIFH IETESFFQYE DNQLIKFKST EINEESNIVQ
EIDDEDDNEI HQNDNKISST GFRSNQMFQK NNQIINNQMR QKKDEVILCK PTDDQNFNKS
NTLWKIINPL NPLDGGFIRW EEKVVLKCLN KNVFLHIKEQ TIGKKKTRQI KLKTSISDES
ECHFHFCQEY QHVELQGEEG QVYQNLENFN LIKINSLFRI VHSETNQTLS AQLYNEIDIN
KQQYDQNRQY NDAQPVLETP KRNSFYSSMT QSIIDQNFLP KIQISSIKQL SQDKKKTEIT
SEENEKIDMK QIVLKENYCE GDVLRFQQIE ELELIESNYL TSTFELISSA IPLIKYYALI
SDKKDETSQK NIFQFTNPYF IEFTSLLSLS IQHQIKYLLD IEFSQDVTFD NSIFRKYKPN
SEKQNLSSKR GILEYSVNLL KAMWGYQSDK KIQDILQSMK KSEDDFNNLE SKAQSNQQSF
LSVCSGRRGT QIKQFKSKID QKDEQIQLYE TFKKLSKLIY FLIITLCKNN SGISINTFNY
FTFFKNHVGY SIGATNAIIS ILKNNEKLLN MIHTKNYHTL SEVKNTISRT LQKLNLKQFQ
KGNHNRFLSA DWKSQNGLDN NNQQIQQVNK KKNTLVNVFF KKYEQVFQNS NNYWANFMDV
MNIMCICKGE ALNINQLIIG QELLANEDPV SSKNLQKMII QIQCKEKKIF IQIYKKTYEL
KEFLDKEQIY FEKSKVQSNE YKFLVKQLGL YANLCKGRNY QNKLLLQDQI TAQALTHYIT
NQNIKTELRA ILLNLLINLH FDSCPRNKVQ RPCYTKTLNS IKHNKTKPKK QSNPNINNSI
CYNIDVNQEP QQNENNQNQN LNISIGSEFI QYDLDEQGSK RVLSRSQRFQ SDLFQNKSQI
NETKQDLQKS LLGGRKRFQS QKMNEESVQI EEVDENEIKK PSQIKDQNQN NLTKNIRPQY
KSIFNNEQDN SNSAVFHEFS LNNFIQKDSM TNQQEMKQFV VNYLRCQIYN EHGQLKSDML
SYYVVKLARM MIIFDYFEKE EEEFFQIIQS LLFILQTQTK VPILEKLRNV YIRNKEHKKA
LHDQEKWKLM IIQEVLQTLL FYQSIQIDSN LRQIVEFITL VFQKFQRPSE CTSKMDFDLY
IKNMIQNRLS NYLPKLQNVQ SYTIDNNSNQ QNPAQSSQKQ DRNKSVMNFN NSPKYYLSML
KQMSNLRDSS KKDVEVLSKY ITFDDMLKNN SFFNIILQNF VSLGSSNIET SHLILKNLFA
NFSQRKNIIR QLKKLQIIMN EKEYYVFKYL KFLNIKTQFI SEMQELWFRN DMKAIVSQKT
AFGEINMLMQ QINLAFYEAA EYDQKEKCLV SKKQLSDLIK EDQIFFCRQQ MLRNLKMHKN
ILSIIREGNI MIQNINQIDK DSANQLEDQQ MIIKMYESCY NFLFLFVKGN KFNQKVLFKY
FELFLQNVGQ FDIGQYKLLR EIMKDNKKIC NSITPEQIQK YITKIYKNGL NNNLEIIKFF
EYLIQDHDEP AYQNIDKLVK CLLESEEFTN FFGLKLITKN SNLEQSPLKK TNAENLMDFN
GQKTIINIQQ ENSIQQSIVN KQQGYSQSNI QVQSLPGQYE FNIDQNVIDL LSGDNTQYIE
KSYKVDDLPF LYNQKSIEIA NQILKYSLNP TKTRYIFNKL ININYIYKLL SLDDIFDKVI
DQTILFTYFK TTLMEFVKQV WLSNEKNSAK LNKNEFLIQF LKKETKKLFQ IKDSMLVSYS
EAMNARTGKE KILYLQNVQK QNSSFQSNSR NNSFLSKNII RPSNSLLVED KDQSEQNNIN
QQSSDDKKDE KIEVISEFGE NKKDDQNQEN DIIKTFHRTS QMKFNINYAC DTNSEEEGKH
DAQIFSSQSS NKFQISQKDL EKKEINVQAI YEERKESEIY YLDPQTQMIE EIIMLVQTDY
IRYLFQCLIP FVMDTFKCFL GYDSQQANVN NRQDYEAFAS FAKEVAVFCE YEITEEIYKK
QKEMILPVLI EFQEIFKVNI DFQFDCKQEI QRYQKERNSK KQNQFEKQSK LEFKSRIIQD
SRIQGIIQPL DGQFIYQGEE QRIRQEVANI ILHLLTSDFV NQNLIIQERN HLVHALRDSH
RSNNLSLQNF LKKLVNFVKN AIDNLEDDDS IILPEDDVLI DTIQLLCDIL DSCTTNEELI
YMQNFLNQNG IIKAMIQFFC QKNEIGKLFK SFISLGIRMI QGINCANFAI QESIYQQMTS
EPNIEIFLAK IIEIIRQEIH FQAFENLSIS QKIEAECKSL KFSYNKHRKF SIQKILRFLQ
LLIANCYTKM QRYLLNQYRS KTNHNILNHI VDLVEAYMGG RSFSQSKFKD GQSYYTDAVT
CDKAVMALET LILLIQGPCI ENQIELAESK FLEIATYILK LNDSYEQFTK VYKKQNSSEI
FLNQEQSIIQ IINQSTQEVN VIQNNISLFK EKLTERQKQL IQSAYEFCPL YSQQLSQIFR
EDHPSNYGVW MLSMIKNKCI SCLESLMDGE NKIITRRIMS DIPPNLLKVN LAWIYEKYEI
LYGEDKYYDF DLFQIKDVKQ IRNELDKTTN KELKLRESLK DSFIIDSGFK IFRILRFILN
QAGNNEIENI YNEIAKREAL VFQIQSKKNI FSQLQNLLQD FAKLFTKIYS FIFRRKVLSN
KMNQEKISSG VDKLKQKSLE FFSKYTGQIE IVQENKLCKI SFPKYPHCFS LTNALKSKVT
RHLNFYSPHT KVESIVKYAD RLIERLKFEH LFKAKLEKNQ SITILSNNLD LWKNLSYFIC
IAQNIYIILT LKHIPGEHDF YFRFIGQDRD FQLFLQLFQI TLASLVLFFF LLKKIPLTHK
KSIEKIQQMD LKKFSINEHT LHQNVIRTDY KTKLRNLKIR VGYIFKDTEL LYFSIYFALA
LLGLFNEFFL ALLLFDVFWR FPMLRSVLHA VWRPRESILL TMFLFFICTY MFSLTAFYFF
VDQFNTLCDN LLTCYSVIFD YMYKNDGGIT SFFAPNGPDD FLEYYGANYS LDWLSLWNFL
YFFIIITLLF SIVTGIIIDT FGLLRDEEDQ KKRNKKDSCL ICSIDRAIID KVSPHNQGFQ
HHIDVEHNLW NYIFYISYLK EKNRNYMLGA ESEIYQKVKI KDISWFPLNR SLSVNQNQET
NEEIDNLNKK IVNMESKLSI ILQEILKNTK VSNKRILKME QQQDLKQLNL FQNTQESNSM
LFSTKMLQST SKKLPQPIRT PKRSHSLWVP QKEQSAEIIE EEDQKKQLNT SLLSSQSVEA
SQEIQKPSIN QNTSQVAQKL TNLMNRCESE DEQ
//
