ID Q22DH5_TETTS Unreviewed; 560 AA.
AC Q22DH5;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 4.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=RING-H2 zinc finger protein {ECO:0000313|EMBL:EAR83383.4};
GN ORFNames=TTHERM_00943050 {ECO:0000313|EMBL:EAR83383.4};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR83383.4, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662797; EAR83383.4; -; Genomic_DNA.
DR RefSeq; XP_001031046.4; XM_001031046.4.
DR AlphaFoldDB; Q22DH5; -.
DR STRING; 312017.Q22DH5; -.
DR EnsemblProtists; EAR83383; EAR83383; TTHERM_00943050.
DR GeneID; 7834623; -.
DR KEGG; tet:TTHERM_00943050; -.
DR eggNOG; KOG0800; Eukaryota.
DR HOGENOM; CLU_490508_0_0_1; -.
DR InParanoid; Q22DH5; -.
DR OrthoDB; 53998at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR011016; Znf_RING-CH.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22765; RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00744; RINGv; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 387..430
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT COILED 102..129
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 560 AA; 66455 MW; 966A0EBE35161BED CRC64;
MEDNIKSQIR APLLDVEADT SQQRGRRAYT SIDLPQQQNI QQGIKNPNQI LELNSNANNQ
AQVNFRHSVG VVNHGEASSD DKTDIQAQQN NFLMGISNQN QNNSLNMGNE NFNENEDEME
EENIDEEEIY DDSNYEMSKL FLSIFNDNRI FLIAVILCDA GMGGLSQLVY SKRCEEMSDL
QYWNFQWGFY FFAKAVYHLF VFTQFFSSAY KLDICQKLGE FRSPEENELR QIEYEQHYTD
RQRSQIRRSL EKQFLDYYYK RTSLLKWAYY IKSLVTLAYV IYGMVVFFSG NYFQIWISNN
YNQPQSQQCD YALTWWVYLS IIFVIACNRQ IFDLILIIAI VLPLALFIYF PYMVYKNCKK
KRKRKQIFKN FKNLKFQVGK VQGDTECTIC RMDYVIDEEI TILPCNELHH FHKDCIMSWL
NVNMTCPLCR HNFAEESSEE EQNEQQIVPA QQGQYVPPLQ NQQQGQIIFQ NQYQQQGVQN
QYNPQQGAQQ PYYQNNVQQN NMQYNNQQYQ DQMILNQLIE MVDLFNDVAD LQRFLQQNNY
PPELQQVIIQ LWHQRQAGMI
//
