ID Q22EI4_TETTS Unreviewed; 1044 AA.
AC Q22EI4;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 83.
DE SubName: Full=Peptidase M16 inactive domain protein {ECO:0000313|EMBL:EAR83668.2};
GN ORFNames=TTHERM_00826840 {ECO:0000313|EMBL:EAR83668.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR83668.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662692; EAR83668.2; -; Genomic_DNA.
DR RefSeq; XP_001031331.2; XM_001031331.2.
DR AlphaFoldDB; Q22EI4; -.
DR STRING; 312017.Q22EI4; -.
DR EnsemblProtists; EAR83668; EAR83668; TTHERM_00826840.
DR GeneID; 7843471; -.
DR KEGG; tet:TTHERM_00826840; -.
DR eggNOG; KOG2019; Eukaryota.
DR HOGENOM; CLU_009165_1_0_1; -.
DR InParanoid; Q22EI4; -.
DR OrthoDB; 5477696at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR013578; Peptidase_M16C_assoc.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR Pfam; PF08367; M16C_assoc; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SMART; SM01264; M16C_associated; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 504..752
FT /note="Peptidase M16C associated"
FT /evidence="ECO:0000259|SMART:SM01264"
FT REGION 1019..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 512..554
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1044 AA; 121636 MW; F8C07437479ACE51 CRC64;
MIRILQKSLN YQQNQKQTKL AQQIFNQFSS SLKERTKAEY NLKEGDQIHG FQVQKIENIN
DFNITAYYLT HLQTDAKFIH FDTKDKNNCL AVIFRTTPHD DKGTPHILEH LTCCGSEKYP
VRDPFFKMIK RSLNTYMNAW TGPDFTCYPF SSQNSKDFKN LMEVYLANTF SPLLKKSDFQ
QEGWRYDFDE ETGDLQYKGV VFNEMKGVYQ SSENIFSESL AKHSIKDSVY NHNYGGDPKS
ITDLSYQEIK DFYNKFYHPT NSKIFSYGDL DFTENLKYIN ENYFNKFQKL NNFDSSVKPS
KRLEKREEYV LKGPEDPVAL DKDKQVKMSI SFLCNDLTQD QIEGNALNLL SYLLCDTANS
PLYKALLESG VAPSYSPGNG FEMHYREGLF NLGVQGISEQ DTETVEKIIF DTLKQISEEG
FDEEMIEGAL HQIEIGAKIP KDNFGIMLIQ MLMTQIIHDG DVSKALKVTE NIQTLRKKIF
EEKYLQKLID KYFLNNKHQV KIVMKADSNY HQEQAQIESQ KLKNIQAQLT QEQIQQIKED
NKTLEKEQSN KNEDYSCLPT LEVSDIDREV ESTEFKQTTY KDIPIYFTNQ NTNGLTFLRI
QFDLERVPLF IRQYLDLFCT FITRIGTKQM KHDEFHKQMS LYTTNFSFDF QSSNRINNND
DPNGPFNYAL LNVACIDRNI EHMFELLQEL LTSPDFNDMT NISTILRNTS NEVANSIIDQ
SMQYAFSVGS ASLRENFFMK EKLKNTRFLC NYSSNFFKSQ SKLYLDDLCF QMHCIIDYMI
KKHKIKFIVH GDQKNFDQIY NNITRMVDNF SFAYPAFKTK NEPLYFDEDY PNPFQRKYIN
KFFTLPMQVN YCIQSLEVPH YTHPDTPVLN LFAELVATSV LHTEIREKGG AYGSGCKLQD
GVMNFFSYRD PNILQTIEAY AKGVKMIADG QFNEENLKES KLSLFSKYDK IINPQDKGLS
YALEGVSDIE RAKYRQGIID ANRENIIRVA REHVQRKIEK NECSKVIFGS ELADLDEIEK
SGYSVEEPVP GFTPQKDEQE NEEN
//
