ID Q22G19_TETTS Unreviewed; 1037 AA.
AC Q22G19;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Cyclic nucleotide-binding domain protein {ECO:0000313|EMBL:EAR84207.2};
GN ORFNames=TTHERM_00721380 {ECO:0000313|EMBL:EAR84207.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR84207.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662576; EAR84207.2; -; Genomic_DNA.
DR RefSeq; XP_001031870.2; XM_001031870.2.
DR AlphaFoldDB; Q22G19; -.
DR EnsemblProtists; EAR84207; EAR84207; TTHERM_00721380.
DR GeneID; 7841069; -.
DR KEGG; tet:TTHERM_00721380; -.
DR eggNOG; KOG0500; Eukaryota.
DR HOGENOM; CLU_269316_0_0_1; -.
DR InParanoid; Q22G19; -.
DR OrthoDB; 52684at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 331..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 439..542
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 1037 AA; 121248 MW; 709C275D83B4C195 CRC64;
MDYQKQKFFN MKVQEVSGFN CKPYQGLLFL DNNSFIQQGG HKGDEDKIQE PDSSQLKDKQ
IYLSEMVLND TNQCQKYTED DVFSVGDTRF YDLYPQNKKM LPEFTHDIIF KNCISNYTQS
DVFTKNCNTP IKLNQGQLPL DLIIKANKNS QNEKQGNNLS ANVISDNQAG TQNCIQNPNQ
QEFDLYPESN NTQKIQKIDN LQQKINSTKL NIDNNFYQKK QQDSITFSKQ QKSELSKLSS
LSEEQNNLHS TCTPNNKIIR ENKSQNLKFT VSLIYLSNIE TKMGYNTTWL SNLNFSNKDH
IDQYLITYYW SITQFMHSGS DLFKPQTKIE LVYGSALTII LGSVLFFSIF TVFLCIFDSK
KDQDKYKKSV RVLTRLLYKN NIDGQLQQRV KHYMLSVKQK QRNEDLQQEQ QAIKNLPKKL
QDEIIQGINS KVFQKMSFYT HIFSQSTNNE LINKMKKVIF NPNETIFEEG KLDDQSVYLI
TDGIVEIFQA FHNTERVVAS LQKNSCFGEI SFFSGKTRSA SARSVNFSTA YKITRQDFLE
VIQSKQKDHE RQKLIQELIL FQNDLKCIKV KCFGCQQIGH TVDKCSILKP QFDKQFIFLR
QRFEHINQRK LFFRKTNKNS RVNCLLNIKA NREILKKLLI DLNIPQSLYS TEPEEDEYED
DDQFTQILQK KKNENQNNNY NNSIINENIL CAEEISPKLQ KTRSIKSVSS KKHDINHTDK
DYQLQQVYLK EQDQSNISIH SILQSPNFIA NNQDTQSEII KEQVHQANQL PRINSDFTRI
TFEEDQLKRK SKNESLDRVS QKQSLLSSVK DIYKSLSNDS NIPSPFIPSI SLNGLDKIWS
QLSSSYDNEE LDKKFQYYYE QIKDPSINVV IKDMASFNNL KKIDQLSLKQ IYDMKLNQII
QSIPFIQNQN NSETSSYLDN HQMSTSINNY SLIFQQFDKI CHFTKFFPHN NFNQIQKQLQ
KIQIIKLQNI KQINSNYQSQ KIMRNMNKQL PSNNQKYLHN QDEENQILYQ SQGITSVSYG
IGYSINPKRG IQNQLIS
//
