ID   Q22GW3_TETTS            Unreviewed;       978 AA.
AC   Q22GW3;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 3.
DT   27-MAR-2024, entry version 85.
DE   SubName: Full=Kelch motif protein {ECO:0000313|EMBL:EAR84561.3};
GN   ORFNames=TTHERM_00655930 {ECO:0000313|EMBL:EAR84561.3};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR84561.3, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662502; EAR84561.3; -; Genomic_DNA.
DR   RefSeq; XP_001032224.3; XM_001032224.3.
DR   AlphaFoldDB; Q22GW3; -.
DR   STRING; 312017.Q22GW3; -.
DR   EnsemblProtists; EAR84561; EAR84561; TTHERM_00655930.
DR   GeneID; 7823664; -.
DR   KEGG; tet:TTHERM_00655930; -.
DR   eggNOG; KOG0379; Eukaryota.
DR   HOGENOM; CLU_307878_0_0_1; -.
DR   InParanoid; Q22GW3; -.
DR   OrthoDB; 5472491at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 3.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR46093; ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5; 1.
DR   PANTHER; PTHR46093:SF17; MULTIPLE EGF-LIKE-DOMAINS 8; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   Pfam; PF13415; Kelch_3; 1.
DR   Pfam; PF13854; Kelch_5; 2.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF117281; Kelch motif; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   4: Predicted;
KW   Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          563..630
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|PROSITE:PS50097"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   978 AA;  114838 MW;  511031491E71C1E2 CRC64;
     MSYQQVQQLT SSSISSKETS SDSTPIKSSN VSIWKEAQLS HKNKEIPSAR WGHSFVKANN
     DLLYLFGGYA ESNYMNDQWV FDLNSFQWIA LPNYGNIPEK RSNHSGCYLE QKNKILIFGG
     GGKEKKRFND VHLYDIDNSN WEYLKVQNSD LITPRTYHSA NLFFDKYLVV FGGEGVGDLN
     DLCVLNLEQE PSWILLQPLG KVPPKRRFHS SATVQNKLYI LGGCFSNYRC HDDIWELNIG
     EYLQDPHNTQ LEWRQIIHYN HVFQPRWGQC SQVYDDKIYI FGGRNLKDLN ETIIFDPSKQ
     ADCLVKIDQT SPNPRRRGAA VVVGSTIVVF GGFDGVYYND IHYLNISQTE NEHNSKIDTE
     SHFKFLQNIM YSQQGYDLEI QMSSFKVGIH KVIVLERMND PKNKAFLNRI EIADVLNLSH
     RDFEQRFFIT TVVQYLYSGV FDYRQIRNQK DLNQLQEFAH EIKLITLLEA LNQNEQWIRQ
     EIQSTLVQRF NSYYFQRYFR YKQHYKKFLS FANSDKKLKS EHNLDSKDKS NNTHQQIKNY
     DPTFVIVNDS IWFEDNEVFY QYSDITLQCE FKQIRANKLL LSSQSLYFKT LFEQAFIEKS
     ESILYIEIVS YSTLKILMNF FYYHKIILPS CFEISDWLNL IEASKYFQIP QIQEICEIEL
     IKMINIDNLF NLYYSSILFN CPKLRKNCSY QYAQKLYSQS IFMEQNPNEQ DDDILIQMGI
     EAQYIYKILR FQISQDKVIE QNAINEAEQI DIEYDNHGDL KKVQEFLSNN INWERQEDII
     NRLKRCNTKQ KSFSHYFNNN MIQNNTQVSN AYQSCYCSNN CEQAFSQNFD SNTNVHIYDS
     GDSSCKQINN YHSAEIEKFN HSTQSSSKCL SQLFQSQDLT VFSKKNYTTS NLQNNQKTSK
     NTKYKNSSNS TNEYSFCLSG RSQDSIQYGT IQNGNKTSSE NCNSDFNADS EEYDIQNTAM
     IEETQTFVQY QSNMEYSL
//