ID Q22HD3_TETTS Unreviewed; 606 AA.
AC Q22HD3;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Monooxygenase family protein {ECO:0000313|EMBL:EAR84768.1};
GN ORFNames=TTHERM_00637700 {ECO:0000313|EMBL:EAR84768.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR84768.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; GG662588; EAR84768.1; -; Genomic_DNA.
DR RefSeq; XP_001032431.1; XM_001032431.3.
DR AlphaFoldDB; Q22HD3; -.
DR STRING; 312017.Q22HD3; -.
DR EnsemblProtists; EAR84768; EAR84768; TTHERM_00637700.
DR GeneID; 7832850; -.
DR KEGG; tet:TTHERM_00637700; -.
DR eggNOG; KOG3855; Eukaryota.
DR HOGENOM; CLU_450953_0_0_1; -.
DR InParanoid; Q22HD3; -.
DR OMA; TAFMLEK; -.
DR OrthoDB; 2786342at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR43004:SF6; FAD_NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR43004; TRK SYSTEM POTASSIUM UPTAKE PROTEIN; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW Monooxygenase {ECO:0000313|EMBL:EAR84768.1};
KW Oxidoreductase {ECO:0000313|EMBL:EAR84768.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 5..381
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
SQ SEQUENCE 606 AA; 70686 MW; E959E7378EEB3D64 CRC64;
MIRKNVAIIG AGPVGLAASM YMEKFGFNYA LIERNQSFIS HPAAHLLNLR SMETLSEIKC
KQDQNKLHEL IYQKCEDINY FRYYRYQRRL FDSREPFYVD DHFYPNPKQK QEEILREHAF
AQYVHLPQPH FVSILKDNIK QKENIYLGHT VLNFKNDKDS VKISLKDHEG NLKQIEADYL
IACDGKHSYV RNSLGIGLVG NPYLQSFFNI YFHSKQLAQT LNERNENAML HFIYNNQVIA
CLVNHSKKEG MFVLQVPTCP PYDDVSTLDK LQKEKIAYEM IQNLIDPSMR DQINDIDIKT
TGMWKLSSEV IEKYYQNRVI FAGDSAHAFP PAGGFGMNTG LQEVHNLAHK LKQIYKYPEH
QEKILQTYHD ERKQFVTEIL NTANKYYKVS LDIAKIIGLN VENYFTFKKT LDVASPFLPK
NLQQFIWKTG IKIGSYPAEI SNPAKISKQL EGNTVPLIFY KEDTEFKYDK GFISSIKTNQ
DDKSLSGLLL PHIMINFKDR QIALRQLANY FYENESEREI VYTDKSRQSQ NKNLIMVALY
KKGFQKEKLQ NFIENLDELF VKPDIIVGCE ASTNSFYEEK LDNLLKNDKQ VILIRSDSII
FGRYEI
//
