ID Q22HI8_TETTS Unreviewed; 1091 AA.
AC Q22HI8;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 79.
DE SubName: Full=Cyclic nucleotide-binding domain protein {ECO:0000313|EMBL:EAR84713.2};
GN ORFNames=TTHERM_00637150 {ECO:0000313|EMBL:EAR84713.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR84713.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662588; EAR84713.2; -; Genomic_DNA.
DR RefSeq; XP_001032376.2; XM_001032376.2.
DR AlphaFoldDB; Q22HI8; -.
DR STRING; 312017.Q22HI8; -.
DR EnsemblProtists; EAR84713; EAR84713; TTHERM_00637150.
DR GeneID; 7846570; -.
DR KEGG; tet:TTHERM_00637150; -.
DR eggNOG; KOG1113; Eukaryota.
DR HOGENOM; CLU_250327_0_0_1; -.
DR InParanoid; Q22HI8; -.
DR OrthoDB; 4604414at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR CDD; cd00038; CAP_ED; 2.
DR Gene3D; 2.60.120.10; Jelly Rolls; 3.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR23011:SF28; CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR23011; UNCHARACTERIZED; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 140..188
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 385..447
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 450..545
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 195..222
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 678..705
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 988..1031
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 25..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1091 AA; 127096 MW; 21788AF6BB88FD77 CRC64;
MSRLNAFFQL VDDPQTPPWK KQAHSQIKEL SKHSKKQTEL DAQEKKRLNL IQQKFAGFLQ
FDYVKETNQD KDGDSSYQSS EDYPDDDEYN AFQMQDEENT QFNKIGIDSI MKALSKKKKS
AFEVKLLSHA LMHNPFFKKM RKQITETLYE ELFKEIYLES YNSLDTVFEF GDTGDKFYII
LQGEVYILSP TQLGIALQQI EKQKEEQAID KLKQESTLQS QKMSANFNQS QMPNDKINEL
QRNSSRHKMS YSKNIATGED DQTPNSFSSQ SPVQQIKRQQ ESLRKQAINR NHNQQKLNDS
FSSFISSEQT PLNQESENYS KFLEKDQQLD QDGASERVRS RNSSFSSSKS QSIRPKQLSL
NERQKEEKKC VIEQKIYQKY PNFYIVKKLQ TGDNFGEIAL RMDKERTATI VCKSNCKFAV
ISKKGFQRIL GDFFRLQLEE KEQFLQNIEL FKGYNFAFLA NILMNIKKKI YNFDDIIYEE
GQDSNKKLYF IKSGEVELSK RVVIPDDPAD TPQSKQFKKN DRVVIAQKQS KEWFGEVEIM
QNMKRFTRAR CVSAKLEVFY ITALKFFANI NIEQMITDMK KSSQMIDEWR QKHYEQMVSR
IYNSKRDPLR KTFSNMQVAH DLINQKFKQE FMKVKPQQII LSKPEETSLA AKIVYFNSVK
SYVNKISDVI GTISKQKYQS IIEQKKDASQ KENDLNKRKE QALQLRSLSL PRNSQILNTS
QNSIQSHARN LSQSSQHQNT PCKLPLILSA EQFDEISAKK SISTAKNSTN TNLASKSVII
NAEHEKLPQL NQHQINKFQT EKSQNFQTEI SQTTDRERKV QSSFSTPMNK KIKLNLNKKI
LSHLCSQNEL EDSSARNNLS QNFPLTTPHT SCTLNYIQHP SKPLISDRLN TDNEILENLY
QEIVGNKQKQ SKLIFNKEMN QKMVEEGMRK KNLQLHQSKQ HGCDFTNLQS SMASLVGIPN
ESLGQDQLKK LKLYRKLKLD NILDYKYQNK LKIELAQKQL QKEAYQNQIQ INKTKDGIES
IQNNLKFTKN QTSLIPKTFS SKIIQSKQKF PNAFSQISLK LPLPQTNQLV NKSLNHHDIF
NKNTIKKKQF E
//