ID   Q22HI9_TETTS            Unreviewed;      1149 AA.
AC   Q22HI9;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   RecName: Full=MORN repeat-containing protein 3 {ECO:0000256|ARBA:ARBA00039854};
GN   ORFNames=TTHERM_00637140 {ECO:0000313|EMBL:EAR84712.1};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR84712.1, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC       {ECO:0000256|ARBA:ARBA00004218}.
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DR   EMBL; GG662588; EAR84712.1; -; Genomic_DNA.
DR   RefSeq; XP_001032375.1; XM_001032375.1.
DR   AlphaFoldDB; Q22HI9; -.
DR   EnsemblProtists; EAR84712; EAR84712; TTHERM_00637140.
DR   GeneID; 7846569; -.
DR   KEGG; tet:TTHERM_00637140; -.
DR   eggNOG; KOG0231; Eukaryota.
DR   eggNOG; KOG0583; Eukaryota.
DR   HOGENOM; CLU_276766_0_0_1; -.
DR   InParanoid; Q22HI9; -.
DR   OMA; KYEGSFD; -.
DR   OrthoDB; 340426at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 15.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR003409; MORN.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR46511; MORN REPEAT-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR46511:SF1; MORN REPEAT-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF02493; MORN; 32.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00698; MORN; 32.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 8.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          71..318
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   1149 AA;  133599 MW;  397CEAE5A6AAE43C CRC64;
     MTKYFVTSHP FMYNQTQMVR SIKKILVFIM QNKEIQKLSK EEIKGFLQSK QSQITSNQIQ
     QSINFLSQYG YHVVQLIDSG SFGIVMKAID SSNSKRYVAI KLIIVTNNEI LKENIQEYQK
     CLLINHPNVI KNYQQLYDEE DECFFIITEF CQKGNLFNFF KQNNIKKEEI VEICLQIFEG
     VLAIHDKNIV HGDLKPQNIL INDDDKIKIC DLGMSKQLLG SKSHTISKGG SLDYMSPEQI
     EGNISKQSDI YSVGCIICFL CNVSIFGLNM VNIKNGIFPP IQENSFKELV NLAFKMMSVE
     PQNRIQLQDS LDQLKQFQKI NSHNQKGKIF VIQFQNGDRY EGEMKDGKMN GKGIYYYKED
     NIRMKYEGQW ANSKKESFGI LEYKNGDKYE GQFKDDLFNG KGIYYYNEGD CGMKYEGQWA
     NGKRNGFGIL EFKNGDKYEG SFDNNLLNGK GIYYYNEGDN RKKYEGQRVN GKRNGFGILE
     FKNGNKYEGS FDNNLLNGKG IYYYYNESDC RKQYEGYWVN SKKEGFGILE YKNGDKYEGQ
     FKDDLSNGKG IYYYNEGDCG MKYEGQWANG KRNGFGILEF KNGNKYEGSF DNNLLNGKGI
     YYYYNESDCR KKYEGYWVNS KKEGFGILEL KNGDKYEGQF KDDLSNGKGI YYFNKDDCEK
     KYEGQWANCK KNGFGILEFK NGDKYEGSFD NNLFNGKGIY YYNEGDYRKK YEGQWANNNM
     NGFGILEFKN GDKYEGSFDN NLFNGKGIYY YNEGGCGKKY EGQWVNGKRN GFGIQEFKNG
     DKYEGSFDNN LFNGKGIYYF NEGNCGKKYE GQWVNCKKEG FGILELKNGN KYEGSFDNDL
     FNGEGIYYYK EDNIRKKYEG QWTNSKKEGF GILEYKNGDK YEGQFKDDLS NGKGIYYYNE
     GDNRKKYEGQ WVNGKRNGFG ILEFKNGDKY EGSFDNDLFN GKGIYYFNKD DCEKKYEGQW
     ANCKRNGFGI LEFKNGDKYE GQFDNNLFNG KGIYYFNEGD YRKKYEGQWA NGKRNGFGIL
     EFKNGDKYEG SFKNGDFNGK GIYYYNEGDN RKKYEGQWAK DKKEGFGILE YKNGGKYEGS
     FKNDNFNGKG IYYFNEGDKR KKYEGQWAND KQEGFGILEY KNGTKYEGYF KNGKKIGKQA
     QVVKHKHSN
//