ID Q22TN0_TETTS Unreviewed; 1201 AA.
AC Q22TN0;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR88408.2};
GN ORFNames=TTHERM_00164980 {ECO:0000313|EMBL:EAR88408.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR88408.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662840; EAR88408.2; -; Genomic_DNA.
DR RefSeq; XP_001008653.2; XM_001008653.2.
DR AlphaFoldDB; Q22TN0; -.
DR EnsemblProtists; EAR88408; EAR88408; TTHERM_00164980.
DR GeneID; 7836165; -.
DR KEGG; tet:TTHERM_00164980; -.
DR eggNOG; KOG0498; Eukaryota.
DR HOGENOM; CLU_003403_0_0_1; -.
DR InParanoid; Q22TN0; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT TRANSMEM 270..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 453..564
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 589..604
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT REGION 53..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1201 AA; 140461 MW; D71BD412C8DFF4EE CRC64;
MDCQVGANFK KRTQRQSINY INSQVDEQRE QQICDTQIDR SRQRFLFELQ NNKLQQSHHG
DSDIQESSFQ ERASSSILDI KNQQSAERTL QPSNSNEIKQ TYKINLENND ETNFHEEFSN
EMHSQKYENQ ECYHEIDNFQ VGDSKVVNQI SSKINFSGQK SLSNQDQSRI DASQNTIVDR
ESESKKNNSV IQRNSRTKAE ENDQIWLQED IFYEKNFKTL GTKVTFALKN KYQEEQENNS
SVKHQQNFKK AANIINRLLN TSMNRHIIKL INQILSLITV AHIAAIGWYF LGIQEKQNNQ
NSWLDKSGIE DNAYYEKYAY SIYWSITTMT TVGYGDIAAT NYIEALYISV VMILFSCVFA
YSINNIGFIL QEIEKSSKQL NDDITIIQRY LIRKDVNIQL KSRVRHYLSF LAYEQKDRDK
QAEDKILSVL SNKLREEITI EINSKILNNY FLFSSNFSQA TLNKLIFIME EVLVNPNEVL
IREKQFDDSS IYFIQSGIIE IYQQQLQNQN KVNVINVLRD GQIFGEISFF SGLQRQASAR
SVNLSTLYKI NRSKFIEILK ENTEDFEKFK MIQDQIIFQN DLQVIHTECY SCKIVGHIAN
QCPKTHKIKD QQIIVLKQNY STFQERAQIE RKIKKYKFQS MNQIKQNKDI FNRLKLNLKQ
QNDQSYMLFQ TKEYLLTSEY SQSKYQNEDD DEENESLSQI PLYFDQQSVN SQNVSKTYSI
KKADKLLKTI KKVNNYILQS NEENESLFNQ ENQCHSNKSL NNQENFELKK AQSNTLYSYV
KTKSLDVTDN INSNTKQESS FNAISSKNAQ ITENNCRSIN KNDTEFLKQN TNEIQSQQSN
QQNEEGFINQ KSIQQAANLI NQSDYEKKQL KQGSNNSILN IQYSNKIQNQ QTDDLNLSFK
DAQIQQPNFT ENQNKLLTSI SMKSKSRNNV SQKSLKLLNQ NQKEQPRCSV EQVLLQNILL
NGLISDKRIS QLQQKNSQTQ LSNIQEIIDK CINYTNRTIK DSKEKTPSQQ SNLSLNQVNN
SNIRDQTLYV YGNSQQIQQN QQQNQNNNSN RNSDIDLIKK LSKIMQNSNI PLLLQLASGK
SFLQPRESQI LSLSMDQFDK LHQFKKYFIH NNFEKVIQKL KKFQQQQKKF KKNKLASKQR
RYNIGLVNHT RLSIFHGNSN LIKFIPQDYD INQYKPTHLS YGVKMQNGVQ FPKNLQSIQN
N
//
