ID Q22U37_TETTS Unreviewed; 1251 AA.
AC Q22U37;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Cyclic nucleotide-binding domain protein {ECO:0000313|EMBL:EAR88850.2};
GN ORFNames=TTHERM_00263460 {ECO:0000313|EMBL:EAR88850.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR88850.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662830; EAR88850.2; -; Genomic_DNA.
DR RefSeq; XP_001009095.2; XM_001009095.2.
DR AlphaFoldDB; Q22U37; -.
DR EnsemblProtists; EAR88850; EAR88850; TTHERM_00263460.
DR GeneID; 7832003; -.
DR KEGG; tet:TTHERM_00263460; -.
DR eggNOG; KOG0498; Eukaryota.
DR HOGENOM; CLU_005539_0_0_1; -.
DR InParanoid; Q22U37; -.
DR OrthoDB; 52684at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 617..725
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 846..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1251 AA; 147332 MW; 2D6AB4E310C351AA CRC64;
MEDSIYESIS FRKEQEKVKE RLSFQMQNMQ KNYSVEDSIL IKNLDYSIIS QTSRLQQNQC
ANHQQNQQQT RINSINLLYQ HDQNPKDIQF LDNNDILLMS PFQFSSVISK DMTPSDQIAG
KIDQNSQQSR QSQYSLQPIQ FDDSTKKQFF TPNNKNNMKP DQNNNFLSEI YQPNDFQNIQ
QNQEGASKTQ VVSFNYSKKQ QLKTQFVLNK FADVKKFVNK LKEKSRRLLF KSISDFQFDI
INDVSSDLDF YLKRKCINQT KRTIGISFLT CLNNQIFGKS FQEFLDGKYL FSLDTLLMQM
WDIFAMLFTI ALIIIIPMMH LLVFQEMNFL IIFHDHIIAW VLIIDTMLSL NTEIYENGVN
IRDRRQIFKQ NFNNLMQDFL ILIIYNFSTS SYKSKMPFLQ NLDYVVFLKY LSIPQKVSEF
ENKLQISDSA KNWMKLIKLE ILVIALAHIA CCIFLKIGLE NIQKGEMSWV IKAGFSTESL
WDLYLQSLYY MIITICTIGY GDISPYQLNE KLYIAFLSIL ATNVTAYAFS QISEIVKFES
SKNQKFNDFM TDVNNQMKKI GLGMSLQVKV RKHFEFVYYQ DEYKQQISES IVDKLPNSLK
NEVLIDIYQE KINSIKMFKE FSSDCLKNIL LSFKQKQLFP DEILLNQYEN SQSLYFLISG
NLEINFQIRE TKSGKTYEKS KQKIQKSEAF GYEGFLLGKC SQYTLKSIGP SLVSYIDRNL
FLQILKQYPQ DYEKFIFMRD SAIFGQKNEF FKFQKCTSCG KFSHQIFDCP YLSLNLTYKP
SKEKNSRLQQ FQRKMERKRN SLNNLIYIQE KAMAAQANND ESAIIDAYNI CLKPISVNDE
KEIQSEFSSQ SLNNSKNNDK AQSSPQIAEK QTIPFQSLSQ KLPYLTNLQN KEQEQLVNEV
SIKIDESGQS DQTQLKANEN TLVNDQDKEK LSEFYQKSKE TDIFNEESCG YRNSNRSILL
TEEVYKDKLS NQDKLNQEKS NGIFNLGSST IDKQYSSQQS GGQFKIQKIN TLLIESSQNY
FEEPEIYLLK QAFQKRKMRS LQQFNNFQRS LSDKVYDTKK SFNFNQSKQN ISLLDILMSL
RDSKLRSQST QLKNIQNKEY LNSLIEQLAL IHKNRSENEI IDSHQYQNQQ IFKESTKQAE
DFNQQIENFT EFSIRQKIGL QDLDMLVVRK QFMLQQQQNK IQNFIQVPDN EIDIDRMQNF
KYYYANYNHK FVLNRYKNYQ DKKQVLSHIK LKKLKKQKIK QQHKNSSKSD I
//
