ID Q22UU1_TETTS Unreviewed; 702 AA.
AC Q22UU1;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Tetratricopeptide repeat protein {ECO:0000313|EMBL:EAR89035.1};
GN ORFNames=TTHERM_00845900 {ECO:0000313|EMBL:EAR89035.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR89035.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG662825; EAR89035.1; -; Genomic_DNA.
DR RefSeq; XP_001009280.1; XM_001009280.3.
DR AlphaFoldDB; Q22UU1; -.
DR STRING; 312017.Q22UU1; -.
DR EnsemblProtists; EAR89035; EAR89035; TTHERM_00845900.
DR GeneID; 7840316; -.
DR KEGG; tet:TTHERM_00845900; -.
DR eggNOG; KOG0577; Eukaryota.
DR HOGENOM; CLU_393068_0_0_1; -.
DR InParanoid; Q22UU1; -.
DR OrthoDB; 231562at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR24349:SF263; CALCIUM-DEPENDENT PROTEIN KINASE 1; 1.
DR PANTHER; PTHR24349; SERINE/THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF14559; TPR_19; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50005; TPR; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT DOMAIN 52..342
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 424..457
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 493..526
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 352..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 702 AA; 81804 MW; 73154ACE95798986 CRC64;
MGNCQIDFQG EKSSRLTISS TNEIQLFKSE ADIQQKNLEL RKAIKSLEAK GYGITQILKF
EDFEVIATVQ EKSTEDMKKF TVKIFFNRLR NECLFDIFDH SPEATIQNEQ DKRQLKLEAQ
NLQKCIHDNI VQIHSYYIQD GISYIFMEEC KYSLAQCIEY RHHLSEIQII EIISELVSGM
SYLHQHNLLV GDFNFQNILY DSQNKLKITS LIFNKASLIN GKFCLYKKSF YQQLNPIFLP
PHIKKIVVQF HEDHDESLFD DHSIIYDQSC DIWGLGILIY ILMGQHIDFV KQYGIRRDTS
TYKEIPSMSQ ELNKLAKQML DCENSINLTI FDIKTMLNNS VIQDAQKRIK TLNDEEQDEN
QETGVSYKGL SRTNTYEADR RSQFNQKPAD KLLFQTDSLK SNQCSQSIKS PDHFDNLDND
NLDKASCIKI GNTYQREQQF DTAEQYYRKA LEFDPYYVPA MINLANLYLQ NEAKSQQAEE
ILNNAAKIDS KNTDVYLMLG KYYSQKKMWK QAYDSFSQVY SSDPNNYNNI LTMGAILEEN
KNYKQALQIY QIATQTSPCK ATAYIRCAEL QLIYSEKESE GKESLKKALQ IDSANKIVKL
YLGILSRDIT LKEDIKRYLE PKKNSIENCK YYLNAGIIFA KYQRNYIAAQ HCFEVCIELA
ELSTPLYNRA VWYLADCLQN ISIQKQKIRE VKQNALKDEQ DD
//
