ID Q22W33_TETTS Unreviewed; 735 AA.
AC Q22W33;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Dynamin central region family protein {ECO:0000313|EMBL:EAR89584.2};
GN ORFNames=TTHERM_00160990 {ECO:0000313|EMBL:EAR89584.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR89584.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR EMBL; GG662820; EAR89584.2; -; Genomic_DNA.
DR RefSeq; XP_001009829.2; XM_001009829.2.
DR AlphaFoldDB; Q22W33; -.
DR STRING; 312017.Q22W33; -.
DR EnsemblProtists; EAR89584; EAR89584; TTHERM_00160990.
DR GeneID; 7833965; -.
DR KEGG; tet:TTHERM_00160990; -.
DR eggNOG; KOG0446; Eukaryota.
DR HOGENOM; CLU_008964_5_2_1; -.
DR InParanoid; Q22W33; -.
DR OrthoDB; 1052588at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF21; DYNAMIN-1-LIKE PROTEIN; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU003932};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 23..291
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 645..735
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
FT REGION 513..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 735 AA; 84175 MW; 8ECC3F73CD98BE41 CRC64;
MDQLIPLINE IHNILHRTNL SNELRLPQIV VIGSQSSGKS SVLESIIGKD FLPRGKGIVT
RRPIEIQLTN ISSGEEYAEI LDRKGEKVTD MEVLTKIIED ETEKVAGKQK GVSGVPLKIR
FYSKNVVDLL LVDLPGITKN PVGDQPADIE QKLLEIVNPY IANPNSIILA ISKGTDDLAN
SESLKLAREF DINGQRTIGV ITQIDLQDFE SENALNDITN KTYPLRLGYV GVVMRGQNQL
KTKTIQEQIV DEAAFFENHS VYRKVADKMG IPYLIKTLNL IFMNHIKKCL PKIRENIIRL
IQIKEDEIRQ YGDFTYLEDK TSKGYLLLNL VSKFANNFND LIHGKYLKSN NDELIGGARI
NYIFNNIFKK CVLEVDPFDQ LSDEDIRTAI KSSNGIRSSL FVPEGAFENL VKQQVSRLYS
PSIQCSHLVY EELRRVINLI NIPEIERFDN LSNKIFEVME DVLSRCLTPT DQMIKNLIEI
ELGYINTNHP DFVGGMSLIQ TQSDNMIVNE EKAVQKSNNG QQNQDKNKQN NVNSSKIEEE
SEESESFWSW LPFQKSNKQT EMLDSKLKMM NLKKKNEDLK SQNSLSETQS IPDQQRKRNY
DINKELNLDY SITNFGMYIP RQNLPPVPNV IRVSEKPSKK EATQTDMIKS LIVSYFNVVK
KNINDSIPKT IISFLVNRAL NICERELVNS IYHEELFDNL LSENTYILQN REETKQQLKV
LRQCMNVIND LDAKF
//
