ID Q22WI1_TETTS Unreviewed; 1671 AA.
AC Q22WI1;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=50S ribosome-binding GTPase {ECO:0000313|EMBL:EAR89436.2};
GN ORFNames=TTHERM_00155550 {ECO:0000313|EMBL:EAR89436.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR89436.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662820; EAR89436.2; -; Genomic_DNA.
DR RefSeq; XP_001009681.2; XM_001009681.3.
DR EnsemblProtists; EAR89436; EAR89436; TTHERM_00155550.
DR GeneID; 7838459; -.
DR KEGG; tet:TTHERM_00155550; -.
DR HOGENOM; CLU_552665_0_0_1; -.
DR InParanoid; Q22WI1; -.
DR OrthoDB; 226254at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01926; MMR_HSR1; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1215..1235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1256..1286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 490..589
FT /note="G"
FT /evidence="ECO:0000259|Pfam:PF01926"
FT DOMAIN 743..832
FT /note="G"
FT /evidence="ECO:0000259|Pfam:PF01926"
FT COILED 360..394
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1433..1461
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1671 AA; 198143 MW; 2B725079921FB1C7 CRC64;
MEKVLKTLDK YNSIILNQSN DSLDERRQKI YSILKQLDKD IQQIEDENYD IYCFYKYFIA
NQSIKYLNLN KNEKETFLEH LSTYKEQVIV KIKNTEMELN QLTFQQPSNN QLIQQYLNKL
KDEVELIKEE DKSFYDHYQK LIFERFVDKQ EKIKKILNTL SQLVKNHSFE EEEEECFQKQ
IQQALKQLEE STRTLEEDDY DQYGYYCFLI AYYRKEYLNL NPKDAENCEN VKNSYRDHIL
NKIEEIYNEV LNITSKMKSI DQTNFQEYLN NLQNEIQFIE KEDYQKFGYY KYIIAENKLN
YLNLDLKQQK KCEQEKKNFM KYYEQYLSLQ YNENLENHHL KAVNIVPNII NQKQILNNQL
NQQETAFKQS TSIIKSLEEN LSQLQKQEKG NENINISNIS SQNFQYANIQ NQNQIQSNQP
TSKQTTIQQL ISSCKTSDIS SLSENESNKQ QLQLSNQISN KSIHEIAREN INKISSQSQK
DESVTQKVYL IMGETGVGKS SFVQYLTGDP RAEIGHQGNS HTQNCRAFIK DELNFIDSPG
INDTNENKYN ILLNIVKYLK QEKYRFQDLF IICVSNKDLN NHLKYLQEIS YTYFLYELFG
DQIKFRDVEK LVNEYYQSTC LLNWQEAGFH SLQDCYTEKR VEIFKNKDQA LNYIQYAQNL
HIIVKTCFDK THKENLKIFN DYQVDFLKQQ IWSNKRENCN DLLAYREYIQ NQEYHLFNKI
KKIIQQWEEV HTWNQGEQIQ YLLLIGGSQV GKSSLIEQLK QISGLRGSGE QSKTSLCQIF
LVEYNKVKYF FIDTPGFEGT ESNQSQYHSL KVISDFLRRN RISEFKVLYM RDADKEVRNG
MPAVLNKLFI FIQEMFDQDS SFIDSAYLRE LITIQASQTN NQQGFINHQL NSIANKILTI
ERVQERKHEG LIYMNIFNNK SIEFQSNFYS FDRKLIQINQ TDDILQKNTL FEGVNQIEPI
CVDEKIYTKI KKIINCKLIN NLSDFMIAFS KLLQLYQQYN NILDQINSRK QVNQIISEDL
NNQRIKIIKD LNNITYIVIG DFQNTQEMKN YIQRQFLYQM QSNNQQNHQN EIKNRILNSI
QKHFLKASYT QYLFEAQQNP NNIFLSRKLL YFWSFTHQLS PFLRDDQKHK KILEQLAKIK
ILQELTVHSH IQSKIIENQY DYTPEQINHQ IQVFFSGMNT ALGTGAQIFR FATYFSNISE
ATLQAQKLAK TVNFVSMWEG FILSALSFGI DLWFYSKGYI CGNQMFLNTS YNAASFSLSV
VALTVPGIGW LAGGIAGAIG LIGYGISAYK YTSFQTFDET LGLVLKTIID DNHPNQILLY
FQKSQFLKQH KITNYSQTQS KDAYEMFRQL EKKNYESGEQ NKFLLKLFNQ SEYPCRLQDE
ISKYIVKNII SKHFYSEIEQ FQDQDPIKYL KVIQKLLERN EKTINTFYKS FYTKNLLNNI
QQNQNELKEI LNKKNDQFKK EKNVQRNCLN DDQNFSQALE TYQLSLKKFI KHIENTDYNY
EEQKEFGNGA LRKCDRYPIT FQGYCNLVHQ KSQYIFKQDT ISEISKKNNC FEVKPENNFN
SQFFQFQDDN ELINSINILI TSDKFVTSRY LLKLKGQDKP SLSFMNDTEV IDAEVEYSID
LYQVADKSNN FKDFVEKIKN KTKNEFDIND EIDMRLRNFF QSIVDLKKIF G
//
