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Database: UniProt
Entry: Q22XS5_TETTS
LinkDB: Q22XS5_TETTS
Original site: Q22XS5_TETTS 
ID   Q22XS5_TETTS            Unreviewed;       915 AA.
AC   Q22XS5;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   07-JUN-2017, entry version 51.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=TTHERM_01005210 {ECO:0000313|EMBL:EAR90096.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR90096.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GG662802; EAR90096.2; -; Genomic_DNA.
DR   RefSeq; XP_001010341.2; XM_001010341.3.
DR   EnsemblProtists; EAR90096; EAR90096; TTHERM_01005210.
DR   GeneID; 7834290; -.
DR   KEGG; tet:TTHERM_01005210; -.
DR   InParanoid; Q22XS5; -.
DR   KO; K02154; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    491    513       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    525    547       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    613    634       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    646    669       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    715    733       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    825    850       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   915 AA;  106007 MW;  6E384C8DA72AEEDC CRC64;
     MRQKVQRIQI KQKIKIKQNQ EIKNIKNYQA KQRGNKQTIN QAKQQNKEDR KQKKYKKTTE
     KMSLLRSDKM AYYNIVIPRE SAWEVLNQLG QVQVVQFEDQ NAHESHMSRV FTPQIKRAED
     ILNQIHIIHN LMVAKQKEVT KCDNIQAYLD VLEVYLRGRE KAYHTFIDDV ESQVKDAFAK
     LNEQTFTLES LTSKYYSLIE YSNVLRKFKE KVVDQRIMSG LDNIAINPLE LAEEGKEEEN
     PLASASKLFY ITGTINKEDT LRFKKIIFRT TKGNSWVFTS EIPYDQGEFK EGFQKSVFIV
     AFSGGSGVLK SKLNRVCDSF NASKYSMPRD PNGYNSKFLE IQQQISDTRQ LMRLTENALN
     NVLDEWIQPR IGNQCSYIEE LRLFVVKEKY IYTNMNMLTV KSAVFGGYFW CPEEQDHAVL
     KAIDKVRTNN PNIGMTEVKK QERPSHLEPP THFRTNDVTA PFQEIVNTYG IPRYREVNPG
     LFCISMFPLK FGIMFGDIGH GGALFAFGAW LVYKGKELLN TPLAALFPAR YLLALMGLFA
     FYCGLIYNDF LALPINLFGS CYYNVHHDGE VHEGQAHYTI EKHENCVYPL GFDPKWYISN
     NELNFFNSFK MKFAVIFGVA QMSWGIFLKG LNCIHFDLWV DLIFEWLPQM VFLLSTFGYM
     CFMIIFKWVS QYEEGYLAPS IINQMINLPL KMGQVSTFNG TPTPLFNDSK FQEELQYNLL
     IISVACVPIM LLIKPLFFLL KKKPQHQEVH DESEPLLQSH APPSHDDHDF NEVFVHQVIE
     TIEFVLGSVS NTASYLRLWA LSLAHGQLAK VFFEKTIGGG IVGGSALQII IGWFLFLNIS
     FAVLMCMDLM ECFLHALRLQ WQLLLQNFVL IDYQILKNLF RVEFQTKFYK ADGYKFEPFS
     FVDALNRANE AEQAK
//
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