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Database: UniProt
Entry: Q22XZ8_TETTS
LinkDB: Q22XZ8_TETTS
Original site: Q22XZ8_TETTS 
ID   Q22XZ8_TETTS            Unreviewed;      2045 AA.
AC   Q22XZ8;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   27-SEP-2017, entry version 78.
DE   SubName: Full=Cation channel family transporter {ECO:0000313|EMBL:EAR90226.2};
GN   ORFNames=TTHERM_00355730 {ECO:0000313|EMBL:EAR90226.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR90226.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662749; EAR90226.2; -; Genomic_DNA.
DR   RefSeq; XP_001010471.2; XM_001010471.2.
DR   EnsemblProtists; EAR90226; EAR90226; TTHERM_00355730.
DR   GeneID; 7837321; -.
DR   KEGG; tet:TTHERM_00355730; -.
DR   InParanoid; Q22XZ8; -.
DR   KO; K21862; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    165    188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    208    228       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    240    269       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    295    317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    400    419       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    425    453       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    732    753       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    759    777       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    789    807       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    813    829       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    850    873       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    935    957       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1251   1274       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1345   1366       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1411   1429       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1459   1482       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1544   1562       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1574   1599       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1606   1624       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1661   1685       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1774   1795       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1812   1847       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    1825   1836       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   2045 AA;  239542 MW;  AC38F8E021393BAC CRC64;
     MNTYVEQYTD TVNYRRGGLF KYPTKGSATL RTQYSLQTRK KKGLIPKKIP EKFTQREYDN
     NELSSKWDVK NKALLEYTSI NEERHYAVGE ERKMVDKSTF QGLNSFQMKS LFFQKDEDLE
     EDNSKKMVQF FYHGKTFTYC KESCQLFKKE HLIRRLSVWI TEWNYYKFFT FITILTMAVF
     MGMHNYNLSD EENIKQGGYQ SIFSYTKYFY ISYFAIEIVL KIIARGLYQS YNSYLKNINN
     LIILIVFGII VIYDTSFIFL FIFRIFYVFE FTSNIKQLRK SYIILKLYQI SGETLFKLLF
     LIFFFITLFG ILSTNIFSGS LDYRCRTTPV PGQGDWELAQ GVYRVCGGRF SCPDNTYCGS
     NYSYIKNDTS YIDSANMDKP TSSRYYNYGI TNFDNLYQTY LTLFLFYMVE GYYNVLYMME
     DSHDQFIPII FVTCYFLVCT YFLNNLIIAI FFIKYQQIES EEEKKNASQK RKSNSVRFQG
     SQQHQQYDAI TNNQSLATNS FYNLKGGAAD SSNKNVNRIY PEKITLNTEK QIQNTFIGLN
     LNSKQQIINP PYKRRNAKQL EELNREKNYG QSIELKQNKQ IDQLNNSNNS NNKKDLKKHL
     EYSKKVSLKS IAEEKDIFYM KDRNVAEELK KFKQLYASEF LDKSISRAET NKNKNNGQQH
     NNFSLAYRTN ASFNSNRRKT FNKIPFSPSI YGQSILNLLQ IKSSKNKIES QQKENELDYN
     RGIIDIFLSN KIFLVFINLC IFCNIIVLSF NQYPAVSDSF YSILKTLNLV FILLFLFEDA
     LRLLSSKQNY YILLGEIIID VTSTVIVFKT KDLVPFSCLK GIRILYAFTN IQKWVNYRIL
     IDAMNHSMSY VINIMLIAFS FMYLGTIIGM WLFGGKLKFN DSDEYDLVNG KSPRFNFDNI
     LSAFTLVFTT IQGDQWNRVW FDCVRSEGSL KAHPYFILLM VIGKTIFLNS FTAIMLASFD
     YANKKSDAAM RGAKTAIDQI LSMKLRRKNS ELPQEMQKKD FIKNDTYKNI NSKFVSKGDD
     DSQSKEDNFK SSVVDSEKQD DKFSLKAQQK KRKVLQQDNN ENRLQTEDNQ LQTLGPLINN
     QDQQTLKDFR SPGLNFKIMP LKNDEIDEQK PRNANYPKPQ KVNEVTSQLG EERTFQRQGS
     NNNDSTPDQR KSPFQLSMSS FKQYNKHRSQ ADLEKEKKKL GKIGFYLKYS SCFMFHKNSF
     IRKNCIRLIE TNYWDNFFLV HIVFSSIQLA LDNPLYDPNS IFKQVLQILN FYFTVVFCVE
     AAIKIIAYGF LYNFTKPDQA YLRSPWNILD FFVNICAIVD LSGFLSTQSL KSLKSLRVFR
     ALRPLKIITK NESLKLLVNS LFQTIPVLTS LAFVILIMTW IFAIFLMSSF KGELQYCSFD
     DINNMVDSDL YKKIVTIQDC NQSGGQWVNQ YFNFDTVFLS VISLFKIILG ENWTQLMWSS
     IDASGIEKQP IKDYQRGYAL IYLLLLFMGN IFTTNLITGL VVNNFKRIKD EISGYKNLTS
     IQRQWVEMQK YMMKRKLKVV IPTPENTYRH FCYILAKSSK FEKIIIFFII LNLVTMGCQY
     KGMDDQGAYA INVINNFCLG IYHVEALIKI VGVGVYFYFK DDWNKFDFGV ILITDIVLFS
     SIFVSTSTVS NLPIIFRALR LGRIVKYIRA SQSLKVLIDS IYYLLPSLIN IAFLVFLIAF
     ICAILGMNLF SQVQLLDGDQ QYPFFDSRAP YPYSYNFQTF TGSFLVILQC IQNQNWDWYI
     QQYGFDQSGC YSQSYSDQQQ DGIKGCSNPL SYPFFLVVVF FLRYIIINLF LALVIEGFFD
     TLKENEAVIS PEVLESIIEK WSVYDQNGTG FIDPEEMYLL LLDIPEPIGL KNEFLQTQIT
     GHGYSQKRDI KDRKSKLQLF SKRKIFQELI NFNVRLYSND KTHFMDFCVK ISRNAIMKKA
     KDNNISDPFL INSRIVIEDS LVQTLMKNWE TEYPTLKKYN KRKDEFNQPK KYFTILNYYA
     AVTIQDYIRQ VQREKKIKEQ IIKNKLSSKM NKTENINTYS LTNNQKQKVL QRNYTNKPWS
     SNNKK
//
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