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Database: UniProt
Entry: Q22YT0_TETTS
LinkDB: Q22YT0_TETTS
Original site: Q22YT0_TETTS 
ID   Q22YT0_TETTS            Unreviewed;      2193 AA.
AC   Q22YT0;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   05-JUL-2017, entry version 79.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR90591.2};
GN   ORFNames=TTHERM_00122400 {ECO:0000313|EMBL:EAR90591.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR90591.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; GG662798; EAR90591.2; -; Genomic_DNA.
DR   RefSeq; XP_001010836.2; XM_001010836.2.
DR   STRING; 5911.EAR90591; -.
DR   EnsemblProtists; EAR90591; EAR90591; TTHERM_00122400.
DR   GeneID; 7833219; -.
DR   KEGG; tet:TTHERM_00122400; -.
DR   InParanoid; Q22YT0; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    118    136       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    156    177       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    189    208       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    251    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    342    364       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    376    398       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    507    529       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    541    558       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    570    586       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    633    655       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    718    745       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1190   1209       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1221   1247       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1259   1277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1284   1303       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1323   1341       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1431   1456       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1515   1534       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1546   1571       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1646   1668       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1745   1767       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1784   1819       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     1942   1999       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2193 AA;  256784 MW;  DACEC387870123BA CRC64;
     MNQTPQKANN QETIAINNIL SSPQYIQQNV QIDQLQNEKN ITRNSQEDIQ FQEGIISKKI
     QDANNEIDRN TQNYLQTHEE QDQQQYSHQN LGQNKEKEES ASKKMTKNNY YRVLNSQTFR
     WIIIASTLAE IAAYLMHDYS YRITKQRKES LQINVVADYF ELITNIIFTI EIIFIIFAYG
     AHRKTLNQIF TTLNALLLTV LISSWISYAT DEIEVFNVYK HFRILTIFRL FPVLAKKVNA
     FFGSFKHLGK TFFPLICVII FYSVIGISFF RGHIESRCRL TKHPEEGETI WEIDESVHLP
     CGVASCPSQS YCGNPAEYGL PEYHHEFDNE HMLWGYVNFN DIFNALFSVY NFLMINGWVA
     TTNIFWRAQD KTVSGIYFVS LVLLLSQIFS NIVLATLYEG FMDSNTSGKQ SSKEGGESTL
     QNDKESKASP TQKKSIFKKK QKNASKFTKH SNDSEQEQEK MRKQGLMLIS QISCVRDDQL
     KYNKGYKLSL FLQSIYKYAK QFRKSTLFSF LHFVNIISII VVLCIDNIQI EGYEYVKLNK
     ADFIVTMIFF SFSFIELITQ GKKYFEQKLL LLDAFIILIT SISYIVESSK GYDIFNPQVQ
     TFIFIRWIKM LRILRLINEF SIFGSLKILL HTYYYTLASL PEFLFLWVLL IVLFVQIGRE
     LLAGMDGGDE HFDEEETIIR INYNTLHNSL IAVIMICYNE EWQLVMYKYR RIVGYKSILY
     HFLAMLILQV LFVRLFIAIF INIFMKWLRE NEIVLYHSQT LVIIKKLTKQ ATNFFNSKRN
     QIQPQQSNTL KENNNIKQQA SIKNSVEEMQ EYQQDGMKGY EKQQNLKNET KMLNQDSQNQ
     KMNGAIQNSQ TKKQNQNGNL NLPKIIHTTS IEKIDEIQMK KQNLKRKQSL EMLRESTQPS
     INVIMSRSKS NENLIDQKQQ QSSRETSSKH QNQLIAYRKI NTHSHASTAF NIVLNNDSSE
     KDQIAEPINQ ENKNDQKQNN IFLLTPQRSI YNRSKSGENE NRNNQDEFNK IEHAKFNIQS
     HNSSQKRTRH SQLPSISLQS PLNSSTVFPF INQNCINEII KQSSREQFQS DAESYPSQSK
     YDRLLIMSLE SLKSQENNDK LSQNGKQNSQ HHSNQQQQQN EFIDKLNNNN NAYNKNLGSN
     SFKELNMTSE QNENSHDINN DEEEEERSLF IFSKENKFRK ICKNIVMHNY FDYFNSICIA
     ALAFLFCADT PFVDPNSSEQ VVIIVFHAIL TAFFIIENIM QIIAYGFIFS PTSFIQRNWF
     FNSIDIITTV ASFFYTVDFW PRSVYVFKFI LILRLTVLFS FLSHQVKEVH HAGMILIKCL
     PRMLRLIIFA AIFLLISGAL TTKLLKGSMH HCYIGDESDG ENSEIPEIIT KFDCLDLGGD
     WIDSQYNFNN IINSLQILFM VQSSEGWIHI MFNVYDSTSP ELNSHYRQNS LWAIFFIQFF
     FIANICILNM FVGLVVETQL EMIESEHKTK DLHKFQKEWL FIKKSIYQLK PSAKVKIPQD
     KVRKFLFDNL IQGNALKIIF YTFTLANCIN LMLFRNRQTQ EEIDKLYLVN EVCLVAMIIE
     IFCRMVCLNL KYFTEPWNVI DLSIVIIGWI NLRFQQTNEF EIFDRGLRIF DGVAKGLQLL
     RFYRIMKHFT IIKKLFKSLQ YAISSIFGIF QVLIIFLFIS VLISMNLFPY IKEQKIINGY
     DVTFRDFPNA LFTLIRVMTS EYWYVVAQEG AKKMQPDFVC FENIILYEDY QKYGQNACGS
     RLSYIFFYGF YLVFTLVILN IFIATIIESY KEAFSADESA VNHYQLDDVL ELWKQYDPEG
     KGYISYKEFW QFSSQIAIIY GVKSEDLMDI QNKNEFLKTL NIPIFEDPIN KVFCYKFHDV
     VISISKISVQ IKYGITTLEP ENSNLRNQLD SLIKKKKLSG DDMIKPTSFT SADMVLIIVL
     TRKVKQWRQK VLGKQEEYIL DIKQLTQKLK SQFNKSQNIN LEQAQKEEEN DKKQTNQEIQ
     QLNQQQTTEQ LKIKDILKED KQQDTEQFIP ITVKSKLPPI EKKKFNSKQS TLNKAEKNVK
     FIECLQTKPQ DTEDGLVLQN NNQDDFNYNN IEQPNKITDQ QFEKNKSLPV KISKQNSNAS
     NNISNTQIQQ KSSSEQNQNQ NIQSPENNNN CQENQEKQFR DEKLKFSILP IEFKATSVIQ
     EQDNYQDDDF GLDVNFNQNF IFAFDEQEET QNI
//
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