ID Q22Z04_TETTS Unreviewed; 780 AA.
AC Q22Z04;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Methyltransferase domain protein {ECO:0000313|EMBL:EAR90517.1};
GN ORFNames=TTHERM_00118620 {ECO:0000313|EMBL:EAR90517.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR90517.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662798; EAR90517.1; -; Genomic_DNA.
DR RefSeq; XP_001010762.1; XM_001010762.1.
DR AlphaFoldDB; Q22Z04; -.
DR EnsemblProtists; EAR90517; EAR90517; TTHERM_00118620.
DR GeneID; 7845715; -.
DR KEGG; tet:TTHERM_00118620; -.
DR eggNOG; KOG2352; Eukaryota.
DR HOGENOM; CLU_010025_1_0_1; -.
DR InParanoid; Q22Z04; -.
DR OMA; REIEWLF; -.
DR OrthoDB; 179741at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12176; SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN; 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EAR90517.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 55..157
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13847"
SQ SEQUENCE 780 AA; 90000 MW; FCE12D2015A200B9 CRC64;
MNILPKNYGE FQSKQYWDKF FRKLKKQNDK KDSEFFEWYG NFKNFQHIIS QIVKEDQKIL
NIGCGNSLFS EDMYDGGFKN IVNCDFSEDV IKEMSARSAK IRPEMKYEVV DIFNMTYAPN
SFDIVMDKGL LDAVYPEETE ENTTKINKFL QSIVDILTAN PNSRYVCISL LQSHILNTLL
TFFNSKNFEI TIHEVLIEKS KLYPFLVDIK RSDNPTATHN KINLHLKNEA EAKLLPPQEI
KHQINRIQTQ NRFMSQVKKC HAGQRFSIEV WDPKVPNAKV PKYTLHVVDS NSKKILENKT
CGCFITPQGK EQSYISSTEK GNFELLEQAG YSRLIIAILN PGYVFSSMKE VQDELCPAVN
DLIPKGCKNL PVPFITDGDE IGDKDVIAQN EEFIIEEILN EEGHALRRLV LKNNISAIQS
QYKMTYFSAK NRPDLVEQNK LTKSILPPKK NMVIGIDESY LDFESHRAMI AGLSLLGADA
FEKKELNILV LGAGLCALSK FIYNHFANTK LNNIEISKNI VEAAKIHFGV DKDPRFKITI
DNAFSYIKNH TVNEEAPKVE KEGSEIEEAK ESKTAPKKKQ QYDIIVIDIV SPQENQASPP
EQFLQEEFLQ KLQKLLENNG LLMINYIGTH QKECDTLLQT KLSKVFDLIY SYKTENELND
VLFAVNTKFK RDVKIDNNNQ KEELIIVEKD QIKQRKELEI NFKQIMKKAV KPWDFTLNID
TLCTKLMLRY PQINTNTLTR TNVYVDQGDN KMVNSTKQQY ENDLGKVLKK EQKKSKNKKK
//
