ID   Q232U7_TETTS            Unreviewed;       935 AA.
AC   Q232U7;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   24-JAN-2024, entry version 67.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR91733.2};
GN   ORFNames=TTHERM_00397050 {ECO:0000313|EMBL:EAR91733.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR91733.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662770; EAR91733.2; -; Genomic_DNA.
DR   RefSeq; XP_001011978.2; XM_001011978.2.
DR   AlphaFoldDB; Q232U7; -.
DR   EnsemblProtists; EAR91733; EAR91733; TTHERM_00397050.
DR   GeneID; 7842035; -.
DR   KEGG; tet:TTHERM_00397050; -.
DR   eggNOG; KOG0500; Eukaryota.
DR   HOGENOM; CLU_604826_0_0_1; -.
DR   InParanoid; Q232U7; -.
DR   OrthoDB; 52684at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR   PANTHER; PTHR45689:SF5; I[[H]] CHANNEL, ISOFORM E; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        239..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        272..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        366..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        422..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        447..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          249..477
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
SQ   SEQUENCE   935 AA;  110240 MW;  35156E061F50C905 CRC64;
     MKNQTIKLNQ VNFTEHIDCD LNTSQNHSNS LHQFKLFQLQ QQNQSLGDYS QSLMQFPTQT
     LFNNAIKQDS KIQNDVQNEI QDKQCSSNNS FENNQKYQQC FEYNSNFTIH NGDIQFQIPQ
     VDQQMPQQNK KLQAQSIFYE RQSLTSANQT SSLFTRYDKS KAINFQNAFD SKEANKTGLK
     QKGYKKRNNL LARDNNAQKE VWKKKWFLIL ALVSKMKKAA QQSSLFFRPQ NLREIQIRLI
     NDLSTINFVA SLILFVYLPF EYCFGLSRGQ FFRYFISYFC TIIFSADIFV KFNTVSSEQG
     NPIEQHMQIF TNYISTTFLF DLICLLSLNS TIFYLDGISF LFFLRIFQPF RILELFREQF
     LLKTKIFGVI SLLYLLAQVI YFAHLFTCLW NYVGLLQLEQ NTGWIVTYNY QTESVSSRYI
     QTFYYAVVTM TTIGYGDFTA QTKLEKLLMI FIAFFSCGIF GYTINSIGNI LYDFKQKRDL
     YLQELAKINK YFKQNNVELG LQCRAKKYIQ YIYSDQYCDQ SCSIKSLSSL SVYLQKEIQQ
     DVYIKMLKKV PIFREIITEQ IFNELALLMK EKIVCHDQLI TCQEEDDEGE HFIYFVNDGT
     ILEFCQYDSK TQIKEIQKFR YGQYFGLAQF MSGNSNQNLK YKSIGVSSVL QLSNSNFIEV
     LRKYDLEYQK FCQAKDEVKF ESKFQKINSY CYSCKQKNHR FEECPYLFYE GKKPIILRQY
     IKENNFKIKH FQRKKQDKSL NALISQEYVA QCADKHFLQN MPCFSMWYES QESGSQSDSK
     SNEKSTNSSQ EHISQEIIQQ EIFRNANSEQ RLGESKKIGS IIEDSSQMQL NGRKFSLQIQ
     KEIQNQFELG ETNQFNIQKV NSSFIPSKIN ILDDEESINL EENLNNQIYK NKKSRSYKNI
     HTKDSFLNIQ NLHEYDQFNS QSKINVLIQS IIKVI
//