ID Q23323_CAEEL Unreviewed; 533 AA.
AC Q23323;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2002, sequence version 2.
DT 27-MAR-2024, entry version 155.
DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN Name=ugt-18 {ECO:0000313|EMBL:CAA99950.2,
GN ECO:0000313|WormBase:ZC443.5};
GN ORFNames=CELE_ZC443.5 {ECO:0000313|EMBL:CAA99950.2}, ZC443.5
GN {ECO:0000313|WormBase:ZC443.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA99950.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA99950.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA99950.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000301,
CC ECO:0000256|RuleBase:RU362059};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167,
CC ECO:0000256|RuleBase:RU362059}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167, ECO:0000256|RuleBase:RU362059}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR EMBL; BX284605; CAA99950.2; -; Genomic_DNA.
DR PIR; T27578; T27578.
DR RefSeq; NP_506209.2; NM_073808.4.
DR AlphaFoldDB; Q23323; -.
DR STRING; 6239.ZC443.5.1; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR EPD; Q23323; -.
DR PaxDb; 6239-ZC443-5; -.
DR PeptideAtlas; Q23323; -.
DR EnsemblMetazoa; ZC443.5.1; ZC443.5.1; WBGene00013900.
DR GeneID; 179759; -.
DR KEGG; cel:CELE_ZC443.5; -.
DR UCSC; ZC443.5; c. elegans.
DR AGR; WB:WBGene00013900; -.
DR WormBase; ZC443.5; CE30714; WBGene00013900; ugt-18.
DR eggNOG; KOG1192; Eukaryota.
DR GeneTree; ENSGT00970000196118; -.
DR HOGENOM; CLU_012949_1_1_1; -.
DR InParanoid; Q23323; -.
DR OMA; NIFTMQF; -.
DR OrthoDB; 382054at2759; -.
DR PhylomeDB; Q23323; -.
DR Reactome; R-CEL-9753281; Paracetamol ADME.
DR Reactome; R-CEL-9757110; Prednisone ADME.
DR Reactome; R-CEL-9840309; Glycosphingolipid biosynthesis.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00013900; Expressed in larva and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF55; UDP-GLUCURONOSYLTRANSFERASE; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 1: Evidence at protein level;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU003718}; Membrane {ECO:0000256|RuleBase:RU362059};
KW Proteomics identification {ECO:0007829|EPD:Q23323,
KW ECO:0007829|PeptideAtlas:Q23323};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU362059};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW Transmembrane {ECO:0000256|RuleBase:RU362059};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362059}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT CHAIN 18..533
FT /note="UDP-glucuronosyltransferase"
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT /id="PRO_5005142808"
FT TRANSMEM 499..522
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362059"
SQ SEQUENCE 533 AA; 61011 MW; 8F06AAEFA1635FB3 CRC64;
MKFALILFFV LIHSTLTYKV LVFNPAYGAS HSNFLGKISD ILIDAGHNVT MLIPEYLITK
KDFVGSKKVK DVVRIGRDER AGKLFEEEGI EHMGRARVWR MDPEMMSLVT IVGSMNLAIG
YQCEYIFQQK DIIDRLRNEH FDLAITESLF ACPFALFDHI GIKNVINAES NLFKDAVKYA
HGEPAAISYY PGLFSPHDDK MSFVARVKNM ITMLFTKYLY GSRYEKELEM IKPYYNGTET
WEDLFTGVAF NLINSNQYID YPSPALPKTV FVGGMQVNTN EAKTKLSDEW NNILNIRKQN
VLISFGSNAF SSEMPEEFKK SFLYVFGNMP EITFIWKYEE ANATLTSHLP NVKLTTWMPQ
NDLLADDRLT LFVTHGGLGS TMELAYQGKP ALIIPLMADQ PRNAHMLKRH GGCLQYHKTM
LGDSEQLLKA FKTVLTERKY SENAQRLARI LRDQPVSPKD LVLKHCEFAV EHGALNSLNS
RGRYLNTFQF YSFDIASSIV MLALLVLVFI YFTLLFIFKL VARIFLSQKT KME
//
