ID Q234R5_TETTS Unreviewed; 1540 AA.
AC Q234R5;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 95.
DE SubName: Full=WD domain, G-beta repeat protein {ECO:0000313|EMBL:EAR91938.2};
GN ORFNames=TTHERM_00101340 {ECO:0000313|EMBL:EAR91938.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR91938.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662767; EAR91938.2; -; Genomic_DNA.
DR RefSeq; XP_001012183.2; XM_001012183.2.
DR STRING; 312017.Q234R5; -.
DR EnsemblProtists; EAR91938; EAR91938; TTHERM_00101340.
DR GeneID; 7841198; -.
DR KEGG; tet:TTHERM_00101340; -.
DR eggNOG; KOG4155; Eukaryota.
DR HOGENOM; CLU_248967_0_0_1; -.
DR InParanoid; Q234R5; -.
DR OrthoDB; 46655at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44324; WD40 REPEAT DOMAIN 95; 1.
DR PANTHER; PTHR44324:SF4; WD40 REPEAT DOMAIN 95; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 96..131
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REPEAT 321..362
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 414..455
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 653..694
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 817..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1252..1302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1329..1354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1474..1540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1093..1164
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1491..1512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1513..1540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1540 AA; 178228 MW; 8B974DD2D2CD619D CRC64;
MDKIKRKEAK SLSLKQKLKK IEPKLQDVIN YLKDHPNLLR FEKNPYTAER LMMLLDNEKL
AALEDEFNEH PNGIELANFI WLMKCAIVHP VEEKYELVTG LIKLFQDIDI NGDKHMEWSE
FTQYIIDAVI GEKDGRFFDA RFEKERELTE NEIIDKAYSR KTKRYVQAKF FDNSTHSNLI
KKIQFSPHND NVIILEQSSN TLKFYTTDCQ EKIINKKKIG LTVPTEYNKV SFIIDFFIAD
SINTIGVVTS KKQLIFWENS FSQKVLKSAK LDVLQTGIWY LPLHQIWVTA GDDFNLKTWI
FTPSNSIGDN KKSKLQHDKL LKAHKGKIMD VVELAAPRLV ASASLDGKIK LWDLTDSEPR
LLTELKDPSN CERGVRQLTY SHQYGSNLLS VGFEQHINVW CPEISITRAF IARLEGHSSL
VVQCKFIPQS PNVISIDDKC NIRIWDIRSM STIQVIAAEG GYSLITDVCF ITGKYDRFLL
AGKRIIYFEN AEVQKNMKNA NDDLYPLSVD FNIYFNQLVI LTKIDMRLYD AMTGRLKKVF
NEIHDDKYSV EMALFCFGAR QRKFFLADNA GMIRQYNMKN GEFLKKVNDV KEIEDSEFSK
KQSHIKKKET NEVSQLIYIN EEKLLIASYW DSTIRIYDES ESEESVLIKV LSGAHKDSEI
ISLSYSAKQN LLASGSANGI VALWDFETGK LEGILKADES EVIQIEFLDP YPVILTTNSA
GVAYLWGSRL APMRYKYKAI LKIMNTHWIN GVETNITINS ILNESYQSEP IPRELPKDGF
EPPEVGQFNP IISRNSNNEK TSKGKKIFFA TNQVTGEDSF LNPQNQNGSN RDSQTINSNH
NLLTSHLFKD EILHSPIRKN DIESSPKGQE ENRETYEMFQ KYWDVYDQNI SKQTQLKNPL
CYVYVGDSKG LMHIWNFTDI LHNRQIFPIK EDKKKQSFQL RRKDLINATK AADNMISGLE
RRNNKNLMVV HATNSVLLKR WVAHTGIVNK LIRIQEPPTL FSCSHDKNVK IWSLEGQYFS
KINIIQYDKP NQWNFPFDWV NQKLNDLDLV FDSLKIIENE QLNKDSKDKV RMKYLTSKYF
SDNEHTELQK IVIEQDEPEK AEKEKQKQEE ENQQVGIKIA YNAKPQLSLQ DEFAKIYQKF
EQEKEEEENR LKRLAQQEKE QNQVDLEYIK KQYRYAKEIN QYKVLELNGN FNQIYYPNDE
ENIIISPQLQ VAVKNLSPNK EQTQNQGVQD KLKLKTSLSN FKIKQNTKFF TNYPSSTTNS
QQQNAINNVD SQNNDNYTNN DNNNNNANQQ TNSYSQAASN QKLHPEQMNN RYTKQQTKGT
HLNYQSTLQL SQGTKDSLPV IQPQTSHSQL RKGVDMKQTA DNFKQKKSSD SLSSSSHKKK
IFTLSTNNFL RNNAFVSSIT KHLQPSSKND DKFKPQIDVK YKLGEVHRCY RVASYKYAYQ
VASDSPQILF ADNELLQKKM KSLKQLHAKK NVDDDDGIDF QDLEDESDNE NTDEASRRGS
TITKKDNKKG NDDSQSLNQS VGFSSFMSKQ KSTTTLNKFT
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